Ferric pyrophosphate citrate (Intravenous)
Commonly used brand name(s)
In the U.S.
- Triferic AVNU
Uses for ferric pyrophosphate citrate
Ferric pyrophosphate citrate injection is an iron replacement product that is used to treat iron deficiency anemia (not enough iron in the blood) in patients with dialysis dependent chronic kidney disease (CKD).
Iron is a mineral that the body needs to produce red blood cells. When the body does not get enough iron, it cannot produce the number of normal red blood cells needed to keep you in good health. This condition is called iron deficiency (iron shortage) or iron deficiency anemia.
Ferric pyrophosphate citrate is to be given only by or under the direct supervision of a doctor.
Before using ferric pyrophosphate citrate
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ferric pyrophosphate citrate, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to ferric pyrophosphate citrate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of ferric pyrophosphate citrate injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ferric pyrophosphate citrate injection in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving ferric pyrophosphate citrate, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using ferric pyrophosphate citrate with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Baloxavir Marboxil
Using ferric pyrophosphate citrate with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Mycophenolic Acid
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using ferric pyrophosphate citrate with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use ferric pyrophosphate citrate, or give you special instructions about the use of food, alcohol, or tobacco.
- Phytic Acid Containing Food
Other medical problems
The presence of other medical problems may affect the use of ferric pyrophosphate citrate. Make sure you tell your doctor if you have any other medical problems, especially:
- Anemia that is not caused by iron deficiency or
- Iron overload—Use is not recommended in patients with these conditions.
Proper use of ferric pyrophosphate citrate
A nurse or other trained health professional will give you ferric pyrophosphate citrate. Ferric pyrophosphate citrate is given through a needle placed in one of your veins.
Precautions while using ferric pyrophosphate citrate
It is very important that your doctor check you closely while you are receiving ferric pyrophosphate citrate. Blood tests may be needed to check for unwanted effects.
Ferric pyrophosphate citrate may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, swelling of the face, tongue, and throat, trouble breathing, or chest pain after you receive the medicine.
Make sure your doctor knows if you are also using other iron supplements. Also, tell your doctor if you have had an allergic reaction to injectable iron products.
Ferric pyrophosphate citrate side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Blurred vision
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- swelling of the hands, ankles, feet, or lower legs
- trouble breathing
- unusual tiredness or weakness
- Bladder pain
- bloody or cloudy urine
- difficult, burning, or painful urination
- frequent urge to urinate
- lower back or side pain
- difficulty swallowing
- fast heartbeat
- hives, itching, or skin rash
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- tightness in the chest
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Back pain
- muscle spasm
- pain in the arms or legs
Incidence not known
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.