ceftazidime and avibactam (Intravenous route)
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antibiotic Combination
Pharmacologic Class: 3rd Generation Cephalosporin
Uses For ceftazidime and avibactam
Ceftazidime and avibactam injection is given in combination with metronidazole to treat infections in many different parts of the body. It belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, ceftazidime and avibactam will not work for colds, flu, or other virus infections.
ceftazidime and avibactam is to be given only by or under the direct supervision of your doctor.
Before Using ceftazidime and avibactam
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ceftazidime and avibactam, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to ceftazidime and avibactam or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of Avycaz® in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Avycaz® in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving ceftazidime and avibactam.
|All Trimesters||B||Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving ceftazidime and avibactam, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using ceftazidime and avibactam with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Cholera Vaccine, Live
Using ceftazidime and avibactam with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of ceftazidime and avibactam. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergy to penicillin, history of—May increase risk of an allergic reaction to occur again.
- Brain disease (eg, encephalopathy) or
- Diarrhea, severe, history of or
- Myoclonus (muscle twitching or jerking) or
- Seizures—Use with caution. May make these conditions worse.
- Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper Use of ceftazidime and avibactam
A nurse or other trained health professional will give you ceftazidime and avibactam in a hospital. ceftazidime and avibactam is given through a needle placed in one of your veins.
Precautions While Using ceftazidime and avibactam
Your doctor will check your progress closely while you are receiving ceftazidime and avibactam. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it and to check for unwanted effects.
ceftazidime and avibactam may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using ceftazidime and avibactam.
Serious skin reactions can occur with ceftazidime and avibactam. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using ceftazidime and avibactam.
ceftazidime and avibactam may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using ceftazidime and avibactam. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.
Check with your doctor right away if you have any of the following symptoms while receiving ceftazidime and avibactam: confusion, loss of consciousness, jerking or twitching of the muscles, seizures, seeing, hearing, or feeling things that are not there, or severe sleepiness.
Before you have any medical tests, tell the medical doctor in charge that you are receiving ceftazidime and avibactam. The results of some tests may be affected by ceftazidime and avibactam.
ceftazidime and avibactam Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:Less common or rare
- black, tarry stools
- bleeding gums
- blood in the urine or stools
- bluish color changes in skin color
- chest pain
- decreased urine
- increased thirst
- irregular heartbeat
- loss of appetite
- muscle pain or cramps
- muscle twitching
- nausea or vomiting
- numbness or tingling in the hands, feet, or lips
- painful or difficult urination
- pinpoint red spots on the skin
- rapid weight gain
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swelling of the face, ankles, hands, foot, or leg
- swollen glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- Difficulty swallowing
- fast heartbeat
- hives, itching, or skin rash
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- tightness in the chest
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Abdominal or stomach pain
- difficulty having a bowel movement (stool)
- Change in taste
- loss of taste
- redness of the skin
- white patches in the mouth or throat or on the tongue
- white patches with diaper rash
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products.
Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved.
More about avibactam/ceftazidime
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 0 Reviews – Add your own review/rating
- Drug class: cephalosporins/beta-lactamase inhibitors
Other brands: Avycaz