Ceftazidime and avibactam (Intravenous)
Medically reviewed on June 7, 2018
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antibiotic Combination
Pharmacologic Class: 3rd Generation Cephalosporin
Uses For This Medicine
Ceftazidime and avibactam combination injection is used alone or together with other medicines (eg, metronidazole) to treat infections in many different parts of the body (eg, stomach, kidneys). It is also used to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).
Ceftazidime and avibactam combination injection belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, ceftazidime and avibactam will not work for colds, flu, or other virus infections.
Ceftazidime and avibactam is to be given only by or under the direct supervision of your doctor.
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ceftazidime and avibactam, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to ceftazidime and avibactam or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of ceftazidime and avibactam combination injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ceftazidime and avibactam combination injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving ceftazidime and avibactam.
|All Trimesters||B||Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving ceftazidime and avibactam, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using ceftazidime and avibactam with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Cholera Vaccine, Live
Using ceftazidime and avibactam with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of ceftazidime and avibactam. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergy to penicillin, history of—May increase risk of an allergic reaction to occur again.
- Brain disease (eg, encephalopathy) or
- Diarrhea, severe, history of or
- Myoclonus (muscle twitching or jerking) or
- Seizures—Use with caution. May make these conditions worse.
- Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper Use of This Medicine
A nurse or other trained health professional will give you ceftazidime and avibactam in a hospital. It is given through a needle placed into one of your veins.
Precautions While Using This Medicine
Your doctor will check your progress closely while you are receiving ceftazidime and avibactam. This will allow your doctor to see if it is working properly and to decide if you should continue to receive it and to check for unwanted effects.
Ceftazidime and avibactam may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are receiving ceftazidime and avibactam.
Serious skin reactions can occur with ceftazidime and avibactam. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are receiving ceftazidime and avibactam.
Ceftazidime and avibactam may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop receiving ceftazidime and avibactam. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.
Check with your doctor right away if you have any of the following symptoms while receiving ceftazidime and avibactam: confusion, loss of consciousness, jerking or twitching of the muscles, seizures, seeing, hearing, or feeling things that are not there, or severe sleepiness.
Before you have any medical tests, tell the medical doctor in charge that you are receiving ceftazidime and avibactam. The results of some tests may be affected by ceftazidime and avibactam.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
This Medicine Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- black, tarry stools
- bleeding gums
- blood in the urine or stools
- bluish color
- changes in skin color
- chest pain
- decreased awareness or responsiveness
- decreased urine
- dry mouth
- increased thirst
- irregular heartbeat
- loss of appetite
- loss of consciousness
- mood changes
- muscle pain, cramps, or twitching
- numbness or tingling in the hands, feet, or lips
- painful or difficult urination
- pinpoint red spots on the skin
- rapid weight gain
- severe sleepiness
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swelling of the face, ankles, hands, foot, or leg
- swollen glands
- unusual bleeding or bruising
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- white patches in the mouth or throat or on the tongue
Incidence not known
- Back, leg, or stomach pains
- blistering, peeling, loosening of the skin
- bloody or cloudy urine
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- dark urine
- difficulty breathing
- difficulty swallowing
- fast heartbeat
- general body swelling
- general feeling of tiredness or weakness
- hives, itching, skin rash
- joint pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- lower back or side pain
- painful or difficult urination
- pale skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red, irritated eyes red skin lesions, often with a purple center
- tightness in the chest
- unusual weight gain
- yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Difficulty having a bowel movement
- stomach pain
- change in taste
- loss of taste
- redness of the skin
Incidence not known
- Collection of blood under the skin, deep, dark purple bruise, or itching, pain, or swelling of the skin at the injection site
- dry, red, hot, or irritated skin
- itching of the vagina or genital area
- pain during sexual intercourse
- tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins at the injection site
- thick, white vaginal discharge with no odor or with a mild odor
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Dosage Information
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- Drug class: cephalosporins/beta-lactamase inhibitors
Other brands: Avycaz