Comparing Tafinlar vs Zelboraf

For Melanoma, Metastatic Have been on Dabrafenib and Mekinist combined for 2 weeks. Melanomas have reduced in size and blood test results were good. Hoping it continues but it is only early days for me. Nausea, pain, itchiness. Taking antihistamines. Melanomas in spine so pain expected.

For Melanoma, Metastatic Cancer returned (metastasized) in abdomen Sept 2011. I ended up in hospital, first parenthesis withdrew 10 liters of abdominal fluid. Given 5 months maximum to live. It is now April 2012. Zelboraf has extended and saved my life. I've been told by specialist in Denver (university of Colorado hospital) that in Europe 42 month life extension has been documented at present time. By dosing with 2 x 240mg pills twice a day! I'd be dead if not for Zelboraf!

For Melanoma, Metastatic Had Isolated Limb Profusion (Left leg) at MD Anderson Cancer center in Houston in Nov 07. Three cancer tumors returned in the same lower left leg in May 2011. In Aug 2011, started Zelboraf at 4 x 240mg pills twice a day (1960mg total a day). Two tumors disappeared within a month of taking Zelboraf. One resisted for six weeks total and was gone. CT and MRI's could find anything after scanning. In July 2013, the one that resisted, returned along with a 5mm nodule. Had some of the complications I was warned about but nothing serious, just uncomfortable at times. Seems like now the cancer is not responding to the Zelboraf and now looking for alternatives. It gave me more years to live with my daughters. Zelboraf is GREAT.