Comparing Lokelma vs Xyrem
| Lokelma (sodium zirconium cyclosilicate) | Xyrem (sodium oxybate) |
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| Lokelma (sodium zirconium cyclosilicate) | Xyrem (sodium oxybate) |
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Prescription only
Lokelma is used to treat high potassium levels (hyperkalemia) in adults, including patients who are on dialysis. High potassium in the blood is associated with medical conditions like kidney disease... View more |
Prescription only
Xyrem is a Schedule III controlled substance when prescribed to treat narcolepsy; however, there is a high risk of abuse associated with it and people who misuse it or sell it to other people are... View more |
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| More about Lokelma (sodium zirconium cyclosilicate) | More about Xyrem (sodium oxybate) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Lokelma has an average rating of 7.0 out of 10 from a total of 3 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 33% reported a negative effect. |
Xyrem has an average rating of 7.6 out of 10 from a total of 109 ratings on Drugs.com. 70% of reviewers reported a positive effect, while 15% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
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View all Lokelma side effects |
View all Xyrem side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Lokelma prices |
View all Xyrem prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
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N/A |
Other sodium oxybate brands include: Lumryz | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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N/A |
1 hour |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
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| Pregnancy Category | |||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 18 drugs are known to interact with Lokelma:
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A total of 346 drugs are known to interact with Xyrem:
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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N/A |
July 17, 2002 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.