Comparing Diphenhydramine vs Mucinex DM
Diphenhydramine | Mucinex DM |
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Diphenhydramine | Mucinex DM (dextromethorphan / guaifenesin) |
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Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
Prescription and OTC
Prescribed for Expectoration, Cough. Mucinex DM may also be used for purposes not listed in this medication guide. |
Related suggestions |
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More about Diphenhydramine | More about Mucinex DM (dextromethorphan / guaifenesin) | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Diphenhydramine has an average rating of 5.5 out of 10 from a total of 529 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 41% reported a negative effect. |
Mucinex DM has an average rating of 5.1 out of 10 from a total of 21 ratings on Drugs.com. 32% of reviewers reported a positive effect, while 47% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: diphenhydramine side effects in more detail. |
See also: Mucinex DM side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
N/A |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all diphenhydramine prices |
View all Mucinex DM prices |
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Dosage Forms Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Other dextromethorphan / guaifenesin brands include: Alka-Seltzer Plus Maximum Strength Cough & Chest Congestion PowerFast Fizz, Alka-Seltzer Plus Maximum Strength Cough & Mucus DM, Allfen DM, Altarussin DM, Ambi 1000/55, Amibid DM, Anti-Tuss DM, Aquabid DM, Aquatab DM, Atuss-12 DX, Balminil DM + Expectorant Sugar Free, Benylin Expectorant, Bidex-A, Bidex-DM, Bidex-DMI, Biocotron, Biospec DMX, Broncotron, Brontuss, Chest Congestion Relief DM, Cofex-DM, Congesta DM, Coricidin HBP Chest Congestion & Cough, Coricidin HBP Multi-Symptom Cold (Day), Cough Formula-DM, Creo-Terpin, Delsym Children’s Cough+ Chest Congestion DM, Delsym Cough+ Chest Congestion DM, Dex-Tuss DM, Diabetic Tuss DM, Diabetic Tussin Cough and Chest Congestion DM, Double-Tussin DM, Drituss DM, DuraDEX, DuraDEX Forte, Duraganidin, Duratuss DM, Duratuss DM 12, ExeFen-DM, Extuss LA, Fenesin DM, Fenesin DM IR, Fenex-DM, G Bid DM, G-Tron, G-Zyncof, Gani-Tuss-DM NR, Genatuss DM, GG-DM SR, GG/DM, Giltuss Children's Cough & Chest Congestion, Giltuss Children's Honey Cough & Chest Congestion, Giltuss Diabetic Cough & Cold, Giltuss HBP Cough & Chest Congestion, Giltuss Honey Cough & Chest Congestion, Glycotuss-DM, Guai-Dex, Guaiasorb Cough Medicine, Guaibid DM, Guaifen DM, Guaifen DM NR, Guaifenesin DM, Guaifenesin DM SR, Guaifenex DM, Guiacough DM, Guiadrine DM, Guiadrine DX, Guiat Clear DM, Guiatuss Clear, Guiatuss DM, Guiatussin-DM, HT Tuss DM, Humibid CS, Humibid DM Pediatric, Humigen DM, Hydro-Tuss DM, Mucinex Children's Cough, Mucinex Children's FreeFrom Cough & Mucus, Mucinex Cough & Chest Congestion, Mucinex DM Maximum Strength, Mucinex Fast-Max DM Max, Mucosa DM, Mucus Relief Cough, Mucus Relief DM, Pecgen DMX, PediaCare Cough & Congestion, Phlemex, Refenesen Chest Congestion Relief DM, Robafen DM, Robitussin Children' s Cough & Chest Congestion DM, Robitussin Cough + Chest Congestion DM, Robitussin Cough + Chest Congestion DM Maximum Strength, Robitussin Cough + Chest Congestion Sugar-Free DM, Rompe Pecho DM, Safetussin DM, Scot-Tussin Senior, Siltussin DM, Siltussin DM DAS Cough Formula, Siltussin-DM DAS-NA, Siltussin-DM DAS-NA Maximum Strength, Triaminic Cough & Congestion, Tusnel Diabetic, Tussi-Organidin-DM, Tussin DM, Tussin DM Max, Vicks DayQuil Cough & Congestion, Vicks DayQuil Mucus Control DM, Vicks Formula 44 Custom Care Chesty Cough, Vicks Nature Fusion Cough & Chest Congestion, Vicks Pediatric Formula 44e Cough & Chest Congestion Relief, Zyncof View more | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
9.3 hours |
3.6 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 448 drugs are known to interact with diphenhydramine:
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A total of 343 drugs are known to interact with Mucinex DM:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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First Approval Date | |||||||||||||||||
March 04, 1946 |
April 29, 2004 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.