Zanubrutinib and Bruising: What Users Say

• Sid...
• Taken for 6 months to 1 year
• June 6, 2024

Zanubrutinib for Waldenström Macroglobulinemia "Was totally fatigued and had severe weight loss. Two weeks on Brukinsa, noticed the difference. Taking 160mg in the morning and 160mg in the evening. After taking these for one year, my weight is back to normal, no serious side effects, did have some bruising at the start. Healed quickly."

• Lar...
• Taken for 1 to 2 years
• November 9, 2024

For Waldenström Macroglobulinemia "Zanubrutinib has handled WM very well for me. All blood test results are within acceptable results. I was initially prescribed 2 capsules in the morning and 2 in the evening. My symptoms improved and I’m now taking 1 capsule morning and evening. Side effects most experienced are general fatigue, occasional constipation, occasional burning urination, and almost always have bruising on my arms and back of my hands."

• Tin...
• Taken for 6 months to 1 year
• August 19, 2024

For Waldenström Macroglobulinemia "I had been on Watch and Wait status for my Waldenstrom's macroglobulinemia for the two years after diagnosis. While I didn't have any symptoms, my blood work for my kidney function started to come back abnormal as my IGM continued to rise. We started treatment to see if the kidney numbers would improve. They improved after one month, and my IGM dropped considerably. It's been nine months since treatment started, and I feel completely normal. I have lots of energy, and it's hard to believe I have an incurable blood cancer. The only side effects that I have noticed include bruising more easily and small purple/reddish pin-sized dots on my skin occasionally. Neither bothers me."

• DrM...
• Taken for less than 1 month
• August 25, 2024

For Mantle Cell Lymphoma "Started 3 weeks ago for MCL. 160 mg BID. Palpable adenopathy essentially already resolved (!) Side effects = bruising, rash, mild purpura on arms, mild petechiae on face and legs, occasional nausea. Interesting side effects = 1.) voice change (much lower, sound like Yoda with a cold) which begins about 2 hours after taking a dose and lasts for about an hour. Very repeatable. 2.) eyelashes appear to be getting longer."

• Ano...
• Taken for 1 to 2 years
• May 8, 2025

Zanubrutinib for Chronic Lymphocytic Leukemia "I've been taking Brukinsa for a year. I take two pills twice a day. The pills are easy to swallow. The only side effect I've experienced is bruising. Occasionally, I have a slight headache, but not bad enough that I need to take anything. My blood counts were in range within 2 months of starting Brukinsa."

• Ano...
• Taken for 1 to 6 months
• May 10, 2025

Zanubrutinib for Chronic Lymphocytic Leukemia "Large red bruise-like patch covering left arm almost completely with small blood bubbles under the skin. Medication 2 months. Lymphs are shrinking rapidly. Based on CT and the shrinking of lymph, I rate it a 10, but I wish the bruises would diminish. No other reactions. Platelets seem WNL. All other labs except WBC 450 and lymphocytes okay, and I don’t have factors."

• Ano...
• Taken for 1 to 6 months
• April 16, 2025

Zanubrutinib for Chronic Lymphocytic Leukemia "Dosage: 160 mg b.i.d. Significantly improved labs. Side effects have been manageable and include nausea, bruising, cough, musculoskeletal pain, constipation, and headaches."