Skip to main content

Promethazine User Reviews & Ratings

Brand names: Promethegan, Antinaus 50, Anergan 50, Adgan Phenadoz

Promethazine has an average rating of 7.3 out of 10 from a total of 376 reviews on Drugs.com. 65% of reviewers reported a positive experience, while 21% reported a negative experience.

Reviews for Promethazine

  • Kaz
  • Taken for less than 1 month
  • December 20, 2020

Phenergan (promethazine) for Sedation "My partner was prescribed 25mg to take each night as he wasn't sleeping. The first night he took one it wiped him out and he was soaking with sweat. I had to help him get undressed and into bed he was that drowsy. The next day he looked drugged up. Then the second night he took another and never woke up, he passed away in his sleep. I thought he was just sleeping until I found him. The post mortem came back un-ascertained and I have been told it will take anywhere between 6-8mnths to get an answer however this is the only new medication he had taken. His other meds he took regularly so I blame this. Please be careful with this drug."

1 / 10
Was this helpful?YesNo
491 Report
  • Mary
  • August 13, 2020

Phenergan (promethazine) for Sedation "Please be careful with these. About 3 years ago I took some to get a few hours sleep. I had to ask the Pharmacist for them as they were kept behind the counter. I got the 25mg’s and had no idea how strong they were. I’m embarrassed and still feel humiliated with what happened. I took 2 at first, I honestly thought they would just give me a few hours sleep and nothing else. I was hallucinating!! I won’t go into great details but I thought my family were in the house with me, they weren’t. My family and neighbour told me some of the things I did. They ended up calling an ambulance. I wrote to the company and also did a long internet search which I discovered that one rare side effect was in fact hallucinating. Please be careful with them. A big lesson learnt, always take as prescribed."

1 / 10
Was this helpful?YesNo
178 Report
  • Sal
  • Taken for 2 to 5 years
  • September 13, 2020

Phenergan (promethazine) for Sedation "I suffer PMS and insomnia. I tried all types of herbs and supplement sleep aids even Melatonin with worked for me for a couple of nights but d be back to the same thing waking up at 3am or not sleeping more than 3 hours a night. My Gp told me about Phenergan. I took the 25mg 2 hours before bed for 5 nights and it 100% worked . Able to carry over month by month with great sleep. Wonder drug thank you Phenergan my friend"

10 / 10
Was this helpful?YesNo
168 Report

Frequently asked questions

  • Joano
  • Taken for less than 1 month
  • August 2, 2019

Phenergan (promethazine) for Sedation "This stuff is garbage for sleep. My doctor put me on this & took me off Zolpidem which worked great. Why screw with what works? Promethazine may work for people with mild sleeping issues but for those of us with severe insomnia it's like taking a skittle candy. Doesn't do a thing!"

1 / 10
Was this helpful?YesNo
201 Report
  • JohnS...
  • Taken for 1 to 2 years
  • October 29, 2020

Phenergan (promethazine) for Sedation "I took 25mg Phenergan to help me sleep. It worked! I've been taking it for almost 2 years but only recently realized, when I stopped taking it, that it was causing me to have a low mood and a REALLY dry mouth to the point where I needed a drink with me at every meeting because it would affect my speech. When I stopped taking it, I woke up 4-5 times in the night, which is normal given I've got small children, but woke in the morning feeling a lot more clear-headed, less headaches and didn't have the need to guzzle glasses of water! Pharmacists only ever warned of drowsiness but not these side effects so wanted to share them with everyone! This medicine will get you to sleep, but it comes with a significant cost!"

5 / 10
Was this helpful?YesNo
125 Report

Are you taking this medicine?

  • Yol
  • Taken for 1 to 6 months
  • December 28, 2021

Phenergan (promethazine) for Sedation "I found half a 25mg tablet good for sleep. Can take hours before it starts working . The first time you take it, it works wonderfully. Be mindful it is an old anti psychotic and has a long half life, so what that means is it builds up in your body. Always start on a low dose of 10mg and increase when needed. High doses can give you restless leg syndrome as it drops your dopamine level. It can also suppress breathing - not ideal!. Best taken an hour before bed as its plasma peak is approx. 2 to 3 hours (the most affect) although that time level is dependent on your rate of metabolism. I am horrified reading how many people double the max. recommended dose when they take the first time, not knowing how it affects you."

9 / 10
Was this helpful?YesNo
85 Report
  • Anxio...
  • Taken for 1 to 6 months
  • October 27, 2020

Phenergan (promethazine) for Nausea/Vomiting "I have panic disorder, so when stressed out I get very nauseous and frequently throw up. The pandemic made my episodes more frequent so I went to my doctor. Zofran had no effect on me so they prescribed this pill. It totally cures the nausea. I do get a bit drowsy but since I take it when I’m hyped on adrenaline anyway it’s usually a relief. I only need 1/4 of a pill, which I take an hour or so before eating or if I feel like a panic attack is coming on. I gave it 9 just because it doesn’t help if I take it right when I feel like I’m going to throw up, you need to take it preemptively. But despite this I would recommend this to anyone who gets nauseous due to anxiety! I love that it has no side effects and it has helped so much in my recovery."

9 / 10
Was this helpful?YesNo
97 Report
  • Anonymous
  • May 16, 2009

Phenergan (promethazine) for Sedation "I've used Phenergan, which is sold over the counter, as a sleeping aid for about one year now. Taken one hour before bedtime, it rarely fails to put me to sleep. The wondrous thing is that I have kept the same dose, and there are no withdrawal symptoms, if you stop using the drug for a week or two. Definitely the best substitute for any prescription sleep aid, that I've ever tried. Highly recommended as a sleep aid."

9 / 10
Was this helpful?YesNo
259 Report
  • Anonymous
  • September 19, 2010

Phenergan (promethazine) for Sedation "Although I have fairly high blood pressure - for which I take medication, and use asthma inhalers to prevent asthma, I have found Phenergan to be absolutely marvelous for insomnia - I have an overactive mind! I find it's best to take it about four hours before I go to bed - then it knocks me out for the night. Sometimes I still feel a bit drowsy in the mornings and have discovered I only need the lowest dose to get a good night's sleep. I only take it the night following a sleepless night. Hope this is helpful."

10 / 10
Was this helpful?YesNo
220 Report
  • Shygirl
  • December 8, 2018

Phenergan (promethazine) for Sedation "I took 3x 25mg Phenergan too help me sleep the next morning I woke up covered in bumps & bruises apparently I had a grand Mal seizure through the night I haven't had a fit in 9 yrs. The chemist failed to tell me this drug can bring on seizures. Just want other people to know about this as I was unaware... Thanks"

1 / 10
Was this helpful?YesNo
106 Report
  • Clack
  • June 7, 2020

For Sedation "I’ve been prescribed Benzos for sleep whenever I’m too anxious, on and off since I was about 20. I wanted to stop using benzos and switch to something weaker and non prescription. I took 2 25mg promethazine tablet first night. Woke up 2 hours later wheezing and felt like my throat was closed up. I was so groggy I couldn’t get out of bed. I don’t remember falling asleep again but I woke up late the next morning. My anxiety that day was worse than the anxiety I felt before sleep. I tried promethazine again a week later, this time only 1 25mg tablet. Slept through the night, woke up groggy and felt that intense feeling of anxiousness and paranoia again. This drug should not be sold over the counter! This drug has worse side effects than benzos! Awful drug! I will never touch it again! If you have anxiety, DO NOT take this drug! It is not safer than prescription anxiety medication and I would consider it the worst drug I’ve tried."

2 / 10
Was this helpful?YesNo
79 Report
  • Shelly
  • Taken for 6 months to 1 year
  • February 4, 2021

Phenergan (promethazine) for Sedation "I took two to get some sleep as I suffer from insomnia and we had a family gathering the following day. Still hadn't fallen asleep by 5am so took another one. Family turned up, I don't remember. I thought there were worms crawling in my carpet, I was talking to a mop which I thought was a person, thought I saw millions of baby spiders on the walls. I lost track of about 36 hours and was hallucinating the entire time! After doing an internet search, I found out they can cause hallucinations! They should have it on the box. I wrote to the company but never heard back. I was so embarrassed and felt humiliated in front of my family. At one stage they phoned for an ambulance. PLEASE be careful with them."

1 / 10
Was this helpful?YesNo
68 Report
  • RickR...
  • August 30, 2016

For Sedation "I was having terrible sleep for past 5 days waking up between 1-3am with intense cramping. My doctor gave me some pills, I have never had a sleeping pill before. I slept non stop, In fact I had some trippy dream that I flew a spaceship to Dubai and landed on a skyscraper.....I now know what Dibai will look like in 50 years....Highly recommend"

10 / 10
Was this helpful?YesNo
124 Report
  • Cmt
  • March 28, 2021

For Sedation "So I've been on this tablets for 4 years now and still on 100mg that I was prescribed. I suffer severely with my sleep as I suffer with bipolar and schizophrenia and these tablets work wonders for me I get a straight 6 hrs sleep which is amazing. I used to be on zopliclone but found myself waking 2 or 3 times a night in my 6 hours sleep this isnt a good scenario for me. I absolutely praise this medication and who knows where I would be without it if here at all. It's worth giving it a try but everyone is different and have different side effects."

10 / 10
Was this helpful?YesNo
56 Report
  • Marty
  • Taken for 10 years or more
  • April 16, 2021

Phenergan (promethazine) for Light Sedation "Almost magic, treating insomnia it works better than my ambien & after waking up I won't discover I have emptied the cookie jar or fridge like has happened on ambien a few times. The downside of phenergan is how long it works, yes the next morning there is some lingering fatigue but it fades & coffee clears that fast. For nausea which I get a lot, it also helps without giving you the gift of constipation like zofran does. Phenergan gets an "A" rating in my book."

10 / 10
Was this helpful?YesNo
53 Report
  • Kelly
  • Taken for 1 to 6 months
  • November 28, 2018

Phenergan (promethazine) for Sedation "Has anyone had weight gain with Phenergen 25mg? I've put on 5 kilos quickly since using this & another drug, Valdoxen. Valdoxen helps which your melatonin receptors, is also an antidepressant, & says you do not put weight on. Not sure which one it is! Phenergen does say it can cause weight gain, esp in females, but they are not sure why. Though they state it's thought it can make you hungry thus you eat more. This isn't the case for me. I've been eating & exercising normally so something is going on. It's fabulous for sleep though, I finally get a great sleep. Confused!!"

8 / 10
Was this helpful?YesNo
80 Report
  • Jamwock
  • Taken for 5 to 10 years
  • February 19, 2015

Phenergan (promethazine) for Sedation "I have no problem falling asleep, but wake in the night and sometimes cannot fall back to sleep. I take one half tablet 12.5 mg of Phenergen and even if my sleep is disturbed I fall back to sleep easily, and wake up refreshed."

10 / 10
Was this helpful?YesNo
115 Report
  • June
  • Taken for 1 to 6 months
  • September 8, 2020

Phenergan (promethazine) for Nausea/Vomiting "I have Cyclic Vomiting Syndrome. Believe me, I tried EVERYTHING for my nausea. Zofran, Omeprazole, Dramamine, etc. You name it, I've tried it. Nothing could stop my violent vomiting episodes. Phenergan suppositories are the only thing that could ever put a stop to my nausea and vomiting. The only problem is, it makes me very very tired, so I can hardly function in classes if I have to take it during the day. But I'll take being a little "out of it" over being so sick any day!"

9 / 10
Was this helpful?YesNo
55 Report
  • Walsh
  • Taken for 1 to 2 years
  • May 10, 2019

For Sedation "I’ve given a review of 8/10, not because this medication isn’t perfect at addressing insomnia, because it is but for the fact it’s just another crutch. I had severe insomnia for approx 2 year, having always been a troubled sleeper. I would be awake all night, on the verge of tears, having to cancel my next day’s clients. It was hideous. This worked like a dream, didn’t make me feel strange or cause a racing heart. If I have issues again, this will be my go to. I just want to share my ‘cure’....binaural beats - a type of music or sounds which really works for getting me to sleep. I listen to them throughout the night, set on a low volume and for the first time, I’m falling asleep almost as soon as my head hits the pillow and waking up bright and early, full of beans. I was also informed that my circadian rhythm was messed up, which is why my sleep signals weren’t working. As well as the binuaral beats, i also limit myself to coffee only in the morning and have tried to drastically cut down on alcohol."

8 / 10
Was this helpful?YesNo
68 Report
  • freddy
  • Taken for less than 1 month
  • May 19, 2019

For Sedation "I was given promethazine for nausea related to anxiety. When anxiety gets bad I can not eat, even the thought or smell of food can make me want to vomit. Sometimes I even get so worked up I do vomit from my anxiety. Promethazine at 12.5mg has helped my nausea tremendously. Also I did notice it helps my anxiety as well! Only down side for me was morning grogginess if I took it at night and light sensitivity during the day. I use this as a substitute for Ativan. It is great and works for two things I now have no nausea, lower anxiety, give it a shot."

9 / 10
Was this helpful?YesNo
64 Report
  • another...
  • July 23, 2013

For Sedation "I'm 73 years old now and started taking Phenergan a long, long time ago. For the last 35 years I've taken a little more than 1/2 of a 25 mg tablet just about every night, about 3-4 hours before I want to go to sleep. Although I wake up about 3 times/night, I fall back to sleep easily and sleep for 8 to 9 hours. It is very "drying" but I consider this worth the good sleep. Often I combine it with 0.5 mg melatonin."

10 / 10
Was this helpful?YesNo
109 Report
  • Gina
  • Taken for 1 to 6 months
  • February 13, 2019

Phenergan (promethazine) for Sedation "I only take 6mg (1/4 of 25mg tablet) at night before I have to work next day i.e Sun to Thurs night. The first time I took a whole pill, never again as it knocked me out but next morning had to stay home as I was so drowsy! I prefer this to taking Lorazepam."

9 / 10
Was this helpful?YesNo
63 Report
  • Jose
  • Taken for 1 to 6 months
  • June 25, 2016

Phenergan (promethazine) for Nausea/Vomiting "I was suffering with nausea caused by panic disorder, anxiety, and depression, my physician prescribed me zofran at first, but I did not like the side effect of major constipation. Thus I told my doctor "is there any other MEDs for nausea", he prescribed me phenergan and it's a miracle drug. My nausea is now barely present."

10 / 10
Was this helpful?YesNo
79 Report
  • Anonymous
  • October 2, 2019

For Sedation "I‘m getting prescribed promethazine for insomnia which is caused by a bad Social anxiety (I get the feeling someone is watching me I‘m sleeping, and generally when I leave my house I get really anxious. Which sometimes leads to me not leaving my house for month other than when I have to work.. etc.) I‘m taking 25-50mg half an hour before I go to bed. It really does help me with my sleep as well which kinda lowers the anxiety that also was caused by my lack of sleep, but it doesn‘t completely kill the anxiety. Just a tip from me if you want to get rid of your anxiety stop taking stuff like benzos or so and quit doing drugs if you currently do any. Start meditating it really can calm you down and makes you get along with yourself! I didn‘t believe it, till I tried it! Promethazine is good for sleeping and that it. Last thing I wanna say: it sometimes doesn‘t help my insomnia as well, that really rarely tho! I‘ve been on this medicament for almost three months now!"

10 / 10
Was this helpful?YesNo
52 Report
  • train...
  • December 16, 2008

Phenergan (promethazine) for Sedation "This medicine helped sedate me when I was having back pain. I had two herniated discs and it calmed me down before and after the surgeries. It is not habit forming and was a plus with all the other medicines I was on."

9 / 10
Was this helpful?YesNo
118 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.