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User Reviews for Rebif to treat Multiple Sclerosis

Rebif has an average rating of 7.0 out of 10 from a total of 26 ratings for the treatment of Multiple Sclerosis. 65% of those users who reviewed Rebif reported a positive effect, while 19% reported a negative effect.

Rebif Rating Summary

7.0/10 average rating

26 ratings from 23 user reviews.

Compare all 94 medications used in the treatment of Multiple Sclerosis.


Reviews for Rebif

CM · Taken for 2 to 5 years March 4, 2021

“My MS therapy was changed to Rebif about 20 years ago because my MS symptoms progressed while on the other therapy. I didn't have any side effects with Rebif but my MS continued to progress so I was changed to a different therapy.”

3 / 10
Fred ML · Taken for 5 to 10 years October 29, 2020

“I was on Rebif for 9 years. The first 8.5 years were fine. The side effects were basically minimal and easy to handle. I eventually developed injection site reactions at 5 of the 8 recommended sites. These were essentially knot-like masses below the skin surface. Kind of like a weird reaction. I stopped taking it about 4 years ago. The masses are very slowly shrinking, one is gone as far as I can tell. If I could do it over again - would I? Yes, in my opinion, it worked for 9 years.”

8 / 10
Bakerjen · Taken for 2 to 5 years October 20, 2020

“When I was first diagnosed with MS I tried copaxone and tecfidera both of these gave me side effects that I couldn't handle, but the Rebif has been virtually side effect free for me. I know everyone is different. All I have to do is take one Advil before an injection and I do not have any of the flu-ish side effects. I have been on this for 3 years now with no new progression of lesions. I will say when I was first diagnosed I was terrified of all medicine and the thought of doing an injection was so scary. Now it's nothing. I still have other issues with my MS and I've thought about trying a new medicine but after looking at the newer medicines the side effects scare me. I think this one is worth a try.”

9 / 10

Frequently asked questions

TiBrink · Taken for 10 years or more July 2, 2018

“I was diagnosed with relapsing-remitting multiple sclerosis (RRMS) in 2006. I was nearly immediately put on Rebif. The worst reaction I have ever had are site reactions. I have learned to manage those by massaging the injection site before and after each injection. Ice helps if it is stinging after the injection, heat if it is aching. I had a pretty severe relapse in 2015 my new Neuro. put me on Tedcfiera. Which was AWFUL. I would (Exactly) 1 hour after taking the medication in the morning throw up for 1 Hour (Exactly) the flushing was miserable. I would flush so hard I would look nearly purple. I had so many physical issues, weight gain, etc. Not to mention I had low levels of JC Virus and was still put on Tecfidera (that combination causes a brain infection) in 2017 I started seeing another NEW Neuro. His first order of business was taking me off of Tecfidera for 1 month and starting me back on Rebif. I have had NO Issues since. I feel like I am human (with standard MS issues)”

10 / 10
hstanley88 July 25, 2013

“I was diagnosed in Nov 2006. Avonex did not work, so early in 2007 I started on Rebif. 6 years no relapses. I would get very bad headaches on the 2 day stretch with no Rebif. I made the mistake of stopping my Rebif for about 6 months and I had a relapse. Face is numb and legs and feet tingly. I regret stopping for the 6 months. I should have called MSlifelines and figured out how to manage the headaches. Regardless, I am back on Rebif and will gladly stuffer a headache if I don't suffer any more relapses. If the goings good..don't quit!”

9 / 10
MarkMark July 9, 2013

“I am a 31 male, 200lbs,and was diagnosed with RR Multiple Sclerosis Feb. 2012, after losing sight in one eye, and some steroid treatment my vision returned however, the color is still a little off. My Neurologist put me on Rebif immediately. Since I have been on Rebif I have not experienced any major relapses. Just some tremors now and then and other minor symptoms that just maybe permanent nerve damage. I take the 44mcg dose at bedtime with 400mg of ibuprofen, it seems to help me sleep through the night. I do get headaches often but the ibuprofen seems to help (not eliminate them). I also get flu symptoms sometimes the day after I take a shot but not always. My liver enzymes are slightly elevated but, nothing to worry about. Thank you Rebif.”

10 / 10
DREW112 · Taken for 2 to 5 years April 22, 2015

“I have been on Rebif 44mg for 3 years now ever since I was diagnosed. I do my The injections at bed time with a little bit of ibuprofen. I have no family history of MS in my family. When I was diagnosed I was in denial, disbelief and very angry. Why me?!! I have so much left I want to do... The side effects I experienced are fever, chills, flu like, and next day dizziness were severe for the first year but no more attacks. Now I experience general fatigue the day after the shot until about noon. I wake up feeling very hot sometimes. Good news is since being on rebif only one new lesion that was stopped with steroids. And come to terms with why me to what am I suppose to learn from this. You can live with this and live well.”

7 / 10

More FAQ

Anonymous February 14, 2012

“First off, I was diagnosed with MS about a year ago, after having many relapses in a 6 month period. I was put on Rebif and after that I have not seen one more problem. It has given me a wonderful peace of mind. Second, I know there is a long list of side effects, however, I have not had one, So I take my shot anytime during the day. Third, my insurance is through Pfizer, which is the co-producer of this drug, so therefore I dont pay a penny out of pocket for this drug. Honestly, thank God for this remarkable drug!”

9 / 10
K. Murph September 19, 2015

“Diagnosed with MS April 2006 after getting double vision. Started using Rebif August 2006. Experienced head aches and fatigue the day after a shot once I tritrated up to the full dose. Was definitely more severe in the beginning, but lessened with time. Ibuprofen has always worked best for me for managing the side effects. 2013 - found out I had Thyroid cancer, and had my thyroid removed. I did not have to stop taking Rebif during this time. Also, first new lesion presented on an MRI - that is 7 years with no remarkable change. September 2015 -- just found out my white blood cell count has dropped remarkably in the last 3 months (I get a Complete Blood Count and liver function done every 3 months, religiously) Probable side effect. Told to stop meds for 1 mo”

9 / 10
JustFunSized June 10, 2015

“I am 21 years old and was diagnosed with MS in 2009. I began Rebif 44mcg March 2015 and unfortunately I have experienced most, if not all of the side effects: fevers, flu, chills, numbness, joint pains, headaches, bruising, nausea, vision issues, bladder issues, etc. I am hoping this drug is for me because I really don't want to have to start over with another one. The injections started off with severe pains, so much so that I am unable to walk after an injection for the rest of the day. But as time past, it is evident that my worse days have gotten better. No relapses so far. I'm hoping these side effects don't stay...”

4 / 10
soul avatar · Taken for 1 to 2 years January 6, 2017

“Rebif is effectively the Indian Rope Trick and very dangerous. All beta interferons cause more harm to the weak body than doing any good. The pharmaceutical lobby sponsors clinical trials and whitewashing the results in relative numbering so they can sell the poisonous drugs. The drugs inflict harm to: - Thyroid - blood - kidney - liver - at long intake risk possibly that your body develops anti bodies against beta interferon and might attack your body's own interferons Google on the web for the Avonex trial that was rigged and initially the NHS health care in the UK banned the medication to be financed. It did cost the NHS 700 Million GBP for a drug that holds off a single relapse in 14 years.”

1 / 10
hwat February 21, 2011

“I was diagnosed with MS in 07/2009 and started this medication in 11/2009. I was titrated up to 22 mg and then titrated up to the 44mg within 4 months of starting medicines. I got an emergency phone call from the Neuro. office after routine blood work came back telling me to immediately move back down to 22mg dose. I had elevated liver enzymes for an entire year on this medication. Finally the levels dropped to normal range. Four months after the liver enzymes normalized I stopped having the flu like symptoms (Fever, headache, general unwell feeling). I take a Naproxen about an hour before each shot. I still get site reactions and some bruising at injection site (and burning when medicine is going in). I use the RebiSmart Injector.”

8 / 10
Tucsonbody04 January 24, 2012

“EXTREMELY blessed to have insurance coverage for this medicine. I have Multiple Sclerosis and am 29 years old. I have been sick for about 3 years now, which was about 6 months after the birth of my first and only child. My prior conditions are mostly autoimmune, ranging from Cardiomyopathy to Crohn's Disease. My disabilities from Multiple Sclerosis include right leg/foot drop or weakness, numbness, urinary issues, balance issues, SEVERE nerve pain, etc. I have been on Rebif for a month and have titrated up to the highest level of 44mcg. I have extreme fatigue, bruising at injection site, and flu like symptoms, but I have noticed the longer I have been on it, the better my worst days are. So I am praying this will work.”

8 / 10
Anonymous September 23, 2010

“I have been on Rebif for a little over 8 years. I still get fever/chills sometimes during the nights I have a shot. This medication has been a life saver for me. I have had no relapses since I began.”

8 / 10
ASYL · Taken for 5 to 10 years April 3, 2013

“Diagnosed in 1999 and was placed on Rebif since 2004. Never had any other meds. Overall Rebif was good for me, I had 3 years with a minor relapse in each year (but did steroid treatment to resolve) and then I had no relapses, I must admit that I would skip at least 2 times a year and give myself a Rebif holiday- a week of not taking Rebif, (I don't recommend this!) I would always let me doctor know. Despite my success, I stopped in 10/2012 because Rebif never let me feel like myself and I was ALWAYS tired and sluggish. Unfortunately, in 3/2013 I had a terrible relapse that landed me in the hospital for a few days. My neuro said it was aggressive and wants me on Tysabri now. ”

9 / 10
Anonymous October 1, 2010

“I was diagnosed with MS almost a year and half ago. I was on Avonex, but symptoms seems to worsen, so my Doctor switched me to Rebif. I wish I had taken this medication from the beginning! I love love love this injection! I have been on Rebif for almost a month now and can already tell a difference. I have not had any symptoms in 4 days! Which is really good for me, because I always have symptoms everyday. I recommend this to everyone! I have had no side effects, but headache. Its been great for me. No injection irritations at all.”

10 / 10
Anonymous May 17, 2009

“I have taken Rebif; it has worked so well and I have had so few side effects that there's been no reason to try out the other disease modifiers. When on a consistent dosage schedule, I never experienced a relapse. The needle is really small. I rarely use my injector anymore - just stab and go. I take it at night to sleep through any effects. I was warned very seriously about the possible side effects, but the worst that I ever have is a slight fever the morning after an injection, and/or the beginnings of a headache that I nip in the bud with migraine medicine.”

9 / 10
Anonymous September 5, 2008

“I have had no relapses since I have been on Rebif. I did not experience the sick feeling, Thank God. I do not like the sting, which can vary from none to a bee sting feeling. Also the mark that it leaves. I use my butt so they can not be seen.”

8 / 10
squirt007 December 8, 2010

“I have been diagnosed with MS since April '09. I was first given Copaxone but that medication failed for me. My Doctor then decided to put me on Rebif and there was only time that I had forgotten to take Aspirin before taking the shot and that time I felt really bad the next day... other than that one time, the only other problem that I dislike about taking Rebif is the concept of giving myself a shot but the good part about Rebif is that it has kept me in remission for roughly a year now. ”

9 / 10
Marge · Taken for 10 years or more September 21, 2018

“I've taken rebif off and on for about 15 years. My MS has gotten worse, but not tremendously. My biggest problem with rebif is the side effects are starting to become worse than my MS. To the point where I'm probably going to have to talk to my doctor about getting off. The side effects caused a crushing headache, extreme fatigue to the point where I can't play with my daughter and general malaise. I've tried other MS medication such as tecfidera and betaseron but they had other issues, which is why I stopped using them.”

5 / 10
SaudiLady · Taken for 5 to 10 years November 27, 2015

“I was diagnosed in 2005. Started out Rebif on 2007 then I had many symptoms when I was on it, less sensation in my tongue, hands, feet and also vertigo. I changed the interferon to another type which I take more often but still same as interferon not sure about the name was horrible too then changed to avonix it was the worst I stopped all since 2011 and never had any symptom since then but I will search and start something.”

3 / 10
FacePlanter · Taken for 1 to 6 months March 15, 2017

“I'm 19yrs old and have been ill for 6 years but only officially diagnosed less than 1 year ago. Due to my age DRs would even even consider MS. I've been on Rebif 4 months, along with 2 infusions of solumedrol and I am going downhill fast. I fall daily, go blind and deaf and lose use of limbs few a times a week. I had to drop out of college due to cognitive issues when I had been a 4.0 student. Rebif has not helped. I struggle to walk, talk, think or even do basic things like eat. I feel Rebif should've helped by now. My mom has a $150 copay that Rebif pays so that's a plus. I have an apt with new MS specialist soon and will ask for new med. I'm not waiting for the "6month" trial period.”

1 / 10
M r · Taken for 2 to 5 years June 5, 2012

“I have had multiple sclerosis since 07/2007. On 05/2012 I have had a relapse. I have been on Rebif since 07/2007, it's awful to have this relapse, my right arm is still not 100% back. Rebif is a good medicine though, I have minimal to no side effects, I do get severe hot flashes during the times I do get to sleep...leaving me to have to constantly change my shirt every 2 hours. Regardless I'm kind of upset that I went through a relapse within 5 years of be being diagnosed.”

8 / 10
mzlupak May 5, 2008

“Rebif has worked better than Avonex for me. Still get some of the flu-like symptoms.”

7 / 10
silly willy69 January 27, 2011

“I have been taking Rebif - I see an improvement in my work and in my attitude and everyday interactions with friends and family. Making me feel a lot better.”

8 / 10
Shereld8808 · Taken for 1 to 6 months May 4, 2018

“I literally spend a whole winter season in the ER cause I got the bad flu symptoms. Sometimes I was there 3-4 a week cause all I did was throw up”

2 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

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