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Xiaflex User Reviews & Ratings (Page 4)

Xiaflex has an average rating of 3.2 out of 10 from a total of 97 reviews on Drugs.com. 21% of reviewers reported a positive experience, while 74% reported a negative experience.

Reviews for Xiaflex

Commonly mentioned side effects
  • Gam...
  • Taken for less than 1 month
  • October 2, 2022

For Dupuytren's contracture "I had the Xiaflex injections on my right hand and was amazed how easy and non-invasive the process was. The next day my doctor gave me a local injection painkiller and manipulated my fingers. The result was instant with no ill effects. I would recommend this procedure over surgery. I understand that Xiaflex is no longer available in Canada and think this is unfortunate for others suffering from this problem."

10 / 10
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  • Bar...
  • Taken for 2 to 5 years
  • June 3, 2022

For Dupuytren's contracture "I've had 2 injections into each hand to correct my Dupuytren's contracture in my pinkies, and it didn't work. Each time, the pinky went back to the way it was prior to the injection. I have recently had surgery on my right hand to remove an excess amount of scar tissue, the likes my new doctor had never seen before. Did more damage than good."

1 / 10
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  • Tom...
  • Taken for less than 1 month
  • May 9, 2022

For Dupuytren's contracture "Horrible experience with Xiaflex. Worst medical decision in my life. Allowed hand surgeon to talk me into treatment with Xiaflex. After treatment, my contracture eventually grew massive, then surgery, leaving horrible scar tissue. Today, had surgery to remove scar and graft."

1 / 10
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Frequently asked questions

  • MFK...
  • October 9, 2022

For Dupuytren's contracture "I was treated for Dupuytren contraction for the ring and pinky finger on my left hand. I had significant discomfort with the Xiaflex injection on fingers, subsequent swelling of the left hand, and minor discomfort in the left armpit, which also turned red. However, after two weeks, the improvement to the fingers has been almost 100%, and it appears to be continuing to improve. Hopefully, I never have to have it again. However, if necessary, I would. Be advised, I’m a 69-year-old male in good health."

10 / 10
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  • Ned...
  • February 28, 2022

For Dupuytren's contracture "Very effective. The secret is a good hand doctor. Completely satisfied with Xiaflex, which corrected a 90-degree bend in my pinkie. Despite a skin tear during follow-up manipulation and the subsequent many bandage changes, it sure beats surgery."

10 / 10
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  • Dia...
  • Taken for 1 to 6 months
  • July 14, 2021

For Dupuytren's contracture "Had left hand done in May and now having right hand manipulated tomorrow. Xiaflex injections are somewhat painful but worth it. The local injections are worse but tolerable, manipulation is nothing. Had minor bruising but no problems otherwise. My right hand has swollen and been a little more painful since the Xiaflex injection earlier, but I am right-handed and use it more. Find a good doctor and get this done, nothing to it!"

10 / 10
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  • fir...
  • Taken for less than 1 month
  • June 10, 2022

For Dupuytren's contracture "It hurts like anything, but is well worth it. Pain is only while you are receiving the injections. Almost normal after 3 days. I think finding a doctor that does this a lot is key and catching it early. My shots were paid for by a grant, except for $150, which the company selling the drug took care of."

9 / 10
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  • Anonymous
  • Taken for 2 to 5 years
  • January 29, 2025

For Dupuytren's contracture "I had the procedure done in February 2023, 2 years ago now. Must have had a good doctor because although I do remember pain during the procedure, it was very bearable and quick. Before the procedure, my ring finger was curved dramatically, and the fingers on each side of it were also being pulled over. After the procedure, I estimate 85-90% improvement in the ring finger and almost 100% in the other two. The thick chord is still going through the middle of my hand. Over the last two years, there has been a slight increase in the curvature of my ring finger, but performing the exercises given to me post-procedure seems to immediately straighten it. I really should wear the hand splint at night because it does seem to temporarily help when I do. I would recommend it as an alternative to surgery, which can be bad, and talk to a doctor about programs to help reduce the out-of-pocket cost. My doctor was very helpful with that! He told me that it was likely to return maybe 10 years?"

9 / 10
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  • Ale...
  • Taken for less than 1 month
  • September 6, 2022

For Dupuytren's contracture "I had it done 5 years ago (the first finger hurt like hell, the second finger I demanded a local). So now one finger is fine and the other is about 20 degrees but okay. So now I have 3 more fingers that are problematic and I go in tomorrow with apprehension due to the pain... local will be demanded. Also, after the first finger was done, I had pain for a couple of weeks. The second finger was fine???"

8 / 10
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  • XIA...
  • Taken for 1 to 6 months
  • October 26, 2022

For Peyronie Disease "Made slight positive improvement, but I lost a lot of length. Now, the penis looks stubby. Very unhappy!! I went from being well-endowed to looking pitiful. Grrrrrrrrr!!"

1 / 10
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18 Report
  • CR2...
  • Taken for 1 to 6 months
  • September 20, 2022

For Peyronie Disease "Wasted lots of time and lots of money. At the end of the day, the condition got worse. Probably a combination of the drug and the provider. Bottom line: stay away."

1 / 10
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  • Did...
  • Taken for 1 to 6 months
  • November 20, 2019

For Peyronie Disease "Went through 2 cycles of shots. My 30-degree bend turned into a 90-degree bend. Sex is impossible now."

1 / 10
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27 Report
  • Tim...
  • July 26, 2022

For Peyronie Disease "I went through the entire series of 8 shots and no change to my 70-degree upward curve, just pain and bruising."

1 / 10
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14 Report
  • Kei...
  • Taken for 6 months to 1 year
  • February 29, 2020

For Peyronie Disease "I went through 3 sets of injections. They came out with the bill before the last set of injections: $51,000 dollars and didn’t help at all."

1 / 10
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22 Report
  • Mik...
  • Taken for 1 to 6 months
  • March 24, 2019

For Peyronie Disease "Useless after five shots :("

1 / 10
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26 Report
  • Car...
  • Taken for 6 months to 1 year
  • June 21, 2022

For Peyronie Disease "Completely worthless, a waste of time and money. I had hopes, however, my condition worsened."

1 / 10
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13 Report
  • Ben...
  • Taken for less than 1 month
  • February 11, 2021

For Peyronie Disease "My 5th round of injections ruined my penis. It has shrunken down to half its size and is bent almost 90%. Xiaflex is too dangerous."

1 / 10
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16 Report
  • Anonymous
  • February 5, 2022

For Peyronie Disease "Zero help. It’s destroyed my personality. Do not use this treatment for Peyronie's. I had 10% improvement and horrible side effects. My zest for life has been destroyed."

1 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • August 29, 2021

For Peyronie Disease "Worthless treatment. Now, I have an added twist along with the bend."

1 / 10
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10 Report
  • Unh...
  • October 9, 2021

For Dupuytren's contracture "Had injection. Painful. But no side effects. In fact, no effects at all. Xiaflex did not work for me. Went on to have surgery, which resulted in 80% improvement."

1 / 10
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  • Anonymous
  • Taken for less than 1 month
  • May 28, 2023

For Dupuytren's contracture "Had this procedure done 2 weeks ago, and it’s coming back. Waste of time and money. Extremely painful and stressful."

1 / 10
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3 Report
  • Ame...
  • Taken for 2 to 5 years
  • July 28, 2016

For Dupuytren's contracture "A very positive experience without no side effects."

10 / 10
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11 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.