Skip to Content


Generic Name: collagenase clostridium histolyticum-aaes (for injection)

Medically reviewed by Judith Stewart, BPharm. Last updated on Jul 7, 2020.

What is Qwo?

Qwo is a prescription medicine used for the treatment of moderate to severe cellulite in the buttocks of adult women.
It is not known if this medicine is safe and effective in children.

Who should not receive Qwo?

You should not receive Qwo if you:

  • Are allergic to any collagenase or to any of the ingredients. See the end of this page for a complete list of ingredients.
  • Have an active infection in the treatment area.

Before receiving Qwo

Before receiving Qwo, tell your healthcare provider about all of your medical conditions, including if you:

  • have had an allergic reaction to a Qwo injection in the past
  • have a bleeding problem
  • are pregnant or plan to become pregnant. It is not known if this medicine will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if this medicine passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you receive Qwo.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take a medicine that prevents the clotting of your blood (antiplatelet or anticoagulant medicine).

How will I receive Qwo?

  • Qwo is injected into the fat (subcutaneously) of each single buttock (treatment area) by your healthcare provider. You may receive up to 12 injections per treatment area.
  • Each treatment visit may include up to 2 treatment areas.
  • Qwo injections will be given 21 days apart for 3 treatment visits.

Qwo side effects

Qwo may cause serious side effects, including:

  • Allergic (hypersensitivity) reactions, including anaphylaxis. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of Qwo:
    • hives
    • trouble breathing
    • low blood pressure
    • swollen face
    • chest pain
    • dizziness or fainting
  • Injection site bruising.

The most common side effects include bruising, pain, areas of hardness, itching, redness, discoloration, swelling and warmth in the treatment area.
These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA 1088.

General information about Qwo

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. If you would like more information, talk to your healthcare provider. You can ask your pharmacist or healthcare provider for information that is written for health professionals.

What are the ingredients in Qwo?

Active ingredient: collagenase clostridium histolyticum
Inactive ingredients: mannitol, sucrose, tromethamine, and hydrochloric acid
The diluent contains: calcium chloride dihydrate, sodium chloride, and Water for Injection, USP

More about Qwo (collagenase clostridium histolyticum)

Consumer resources

Other brands

Professional resources

Related treatment guides

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.