Collagenase clostridium histolyticum for Peyronie Disease User Reviews (Page 2)

• Ben...
• Taken for 1 to 6 months
• September 29, 2021

"Look for other options! Unless you're into your penis looking like balloon art. My doctor bragged about it, telling me all his success stories. How it was my only option. I never had an ultrasound or imaging before or during the procedure. However, he mentioned during my 2nd injection that I had the largest plaque he had performed the injection on. At one point, he asked me where he should inject it. That’s after he already jabbed my penis 5 times trying to hit plaque and injecting a little each time. If I had known what I know now about this drug, I would have even looked at natural alternatives."

• my ...
• Taken for 6 months to 1 year
• March 2, 2022

"After receiving 4 injections for Peyronie's disease manifested by an approximate 30-degree curve to the left, I find myself at least one inch shorter and a curve upward larger than the previous curve. I'm told this curve is not due to plaque, therefore, not correctable. Sex, that is penetration, is almost impossible with this particular curve. I was better off before this treatment."

• Tom...
• Taken for 6 months to 1 year
• January 28, 2022

"After two rounds of Xiaflex, I can say I’ll never have a third. Never recommend to anyone, no matter how bad your PD is. The pain, swelling, blisters, and bleeding are an 11 on a scale of 1-10. Nothing is worth what this horrific drug has done to me."

• Ano...
• April 2, 2021

"It's been 9 months and 2 injections every 6th week. No discomfort after initial injection. Always bruised for a few days. Went from 75% curvature to 50%. Opted to continue. Must go to an expert in this field. The details are important. The stretcher must be from Mayo Clinic. Must adhere to wearing it as directed. The stretcher allows growth of good tissue in the right area. My doctor has treated over 5,000 patients from all over the world. UCSF has their own PD unit. Highly recommend."

• Anonymous
• Taken for 6 months to 1 year
• September 3, 2020

"Don't waste your time or money. I went to my urologist for the treatment, who was excellent. Little bruising or discomfort with the injections. After 4 courses of injections over several months, NOTHING. I even purchased an expensive traction device and followed the instructions perfectly.... The only option for this disease, unfortunately, is surgery if you want any results at all. So glad my health insurance paid for this as it's VERY expensive and ineffective."

• Xia...
• April 14, 2022

"I have more of a curve now than I used to. My penis is all black and blue. My urologist was shooting other injections right in the bruising. Throbbing pain. Shortness of breath. Headaches. It's not worth it at all. I had way better results with acoustic wave therapy. Girth was better and it was straighter."

• Xia...
• Taken for 1 to 6 months
• January 17, 2020

"Terrible experience with Xiaflex! This is a very bad drug! It left me worse than I was! I wish I would have never done this. I felt a burst, worst bruising ever. So very painful! I still don't feel right, this has messed me up big time! This drug should not be used for this! Rating this drug as a 1 is too high!"

• Dis...
• Taken for 6 months to 1 year
• November 3, 2022

"Painful and stressful. It seemed to break up plaque a little after the 2nd round. No further progress after that. By the 3rd round, there was more plaque developing and curvature actually got worse. I only give it more than one star because I do believe it helps a few people, but not a high percentage. It was worth trying at least."

• in...
• Taken for 1 to 6 months
• January 17, 2024

"I just finished my second round. Like most others, the first set of shots were not that painful but uncomfortable. The second shot of the first series was given 1 week after the first. I purchased the traction device that bends and used it as directed. The second round of shots was done on successive days and it was much more painful with a lot more bruising and pain. I couldn't use the traction device for over a week because it was too uncomfortable. I just went in for an assessment of the curvature and it went from 60 to 50 with no change in length or girth, for which I'm grateful. I am scheduled for my third treatment in a week. I can't say anything too bad about the whole experience, other than I was hoping for a more significant change. But I trust the doctors at Mayo. I will let everyone know of any changes moving forward."

• Ext...
• Taken for 1 to 6 months
• October 10, 2022

"I had my 4th injection from my urologist a month ago for Peyronie's disease. It was so painful all the muscles in my back locked up. Since those injections, I have barely been able to walk. So I went to my primary doctor, who said I have arthritis in my hip, but how suddenly the pain and inability to walk due to feeling like tendons were ripping made me think there’s something else wrong. The pain is only 3-6 inches away from my penis, so I thought maybe Xiaflex related. I had to read about bad experiences when used on people's fingers to find out that some doctors messed up and didn’t get it injected exactly where they should, and it trickled down onto tendons in hand, causing damage. So now I believe that maybe it trickled off the plaque down to the tendons toward my left hip. The inability to walk without extreme pain is just getting worse. It’s been a week, and my primary care doctor hasn’t called me back."

• Rus...
• December 21, 2020

"I am very satisfied with how things have gone and am happy that I chose to go the Xiaflex route. I have had two sets of injections, with the third set scheduled. I started out with a 65-degree curvature and am now down to 20 degrees. I would be thrilled if I was left with no further improvement since 20 degrees is mild compared to where I was. Yes, the injections are painful, but that isn't surprising considering the location. And I experienced severe bruising each time and a bit of pain for about three days afterwards. I should add that I also have Dupuytren's, so that is the source of my plaques, not injury."

• Ray...
• Taken for less than 1 month
• December 6, 2023

"I had my first injection. After reading all the horrible reviews, I was terrified but decided to go with it. I had my first injection. No pain. Normal injection pain, 24 hours later no swelling and no bruising. Making me wonder did I get an injection of Xiaflex or saline water? Was told due to my extreme curvature it would take multiple injections. I just pray it works. If I have any more curvature, it'll be a complete loop. Any more shrinkage and it'll be gone."

• Sti...
• Taken for 1 to 6 months
• November 2, 2021

"I went through two cycles of this treatment, and for me, all it did was change the bend. It bothers me more than it does anybody else. Not to disparage my doctor, but he didn't describe the penile molding as well as he should have until after the second shot of my second cycle."

• Anonymous
• February 10, 2021

"On my second shot, but I think this is it after reading some of these comments. I'm praying to God that I don't get any shorter than I am now!!! I'm still tender at the base after one week. It looks better, but trying to stay away from an erection."

• Big...
• Taken for 6 months to 1 year
• September 7, 2021

"Completed 4 sets of 2 injections (8 injections total). It wasn't pleasant receiving the shots. Nor was it easy not having sex for a month after each shot. But everything does appear to be straightening out. It is longer and thicker. Would not go through it if there was a better choice. I have had surgery on my hands for Dupuytren's, as well as the injections too... Surgery is a rougher path. Surgery on the hand was bad enough, injections a better alternative. And the stories you will have will make your friends cringe. Wish I had known about the numbing cream. But done now. Doctor says it can take up to 9 months to get full benefit. It is working great then... Kind of like getting a dick lift."

• Ric...
• Taken for 1 to 6 months
• March 5, 2023

"I saw results after the first round of treatment, but after the second round, went from a 60-degree to a 20-degree curve. I am on my 4th and last round, and I am at an 18-degree curve. The first round of 2 shots is bad. On the first day, you get 1 shot to erect the penis, and the 2nd shot brings it down, then you get the Xiaflex shot. I will not lie, all 3 shots hurt for a few seconds, and it is unpleasant. But so far, it is worth the few seconds of pain. I hope after this round back to normal or close to it. It made my sex life great, and my wife is happy with the results. I went on a website and got a grant for Xiaflex. Between insurance and the grant, it cost $0 for Xiaflex, but I had to pay for the medication to erect my penis and one to bring it down, which cost about a total of $150.00."

• Car...
• February 19, 2021

"I am a 56-year-old male of good health. Just finished my 3rd round of therapy, including modeling. I had a 45-degree curvature, which is now 20% and very functional and manageable. I had a good urologist that followed the recommended protocol to the letter. Although the injections were painful initially, I was able to tolerate them more in the subsequent series. Furthermore, I had my doctor provide me with a Novocaine numbing cream about 5 minutes prior that reduced injection pain considerably. Make sure you ask for that, as it makes a considerable difference. I did have some bruising after each injection, but it always cleared up within a week and was manageable. I am very happy with the results so far and will see him in two months for a Trimex evaluation to determine whether I want to proceed any further. I would recommend this therapy. However, find a good urologist, and do all of the home modeling he recommends between series and beyond so you continue to stretch and reform."

• SCA...
• Taken for 1 to 6 months
• December 29, 2023

"Xiaflex injection therapy worked, but only on the sides that had less scar tissue. My urologist was very arrogant, and I kept telling him that most of the scar tissue was on the left side. Because I was to only have so many injections, the left was never treated. He told me he used the photo of my penis to choose where to make the injections. Why didn't he use a marking pen? I read that it was the best way to inject Xiaflex into the plaque that needed it the most. He never did. Now I have an upward curve, and it still bends to the left when erect. I lost an incredible amount of length and girth. I haven't even tried to have sex because of it. Very disappointed in the doctor. Xiaflex did get rid of the plaque where he injected the Xiaflex, though. I need another treatment for the plaque on the left side!!!!"

• Eri...
• Taken for 1 to 2 years
• September 9, 2021

"I’m very surprised by the bad experiences. Fortunately, my experience has been good. I’ve had 3 series. I completed shot 1 of the 3rd today. I’ve never had a reaction, but on the way to the car, I had pain from my sacrum to my knees. I had to wait a bit before driving home. Not sure what that was about. As far as success, some length loss, but girth returned and has straightened. I’ve been pleased."

• Kei...
• October 1, 2020

"Opted for surgery over Xiaflex. Had plaque the entire length with a hinge at the top third. Now totally straight without ED, but lost substantial length and girth where the plaque couldn’t be removed. Overall, it’s a better deal. Doc Hauser was very good at taking me from a 110-degree curve to a 0-degree. Lament the length loss, but I’m straight as an arrow!! Also asked (kept asking) and received male intimate care post-op, which lessened my already strained emotional state."

• XIA...
• Taken for 1 to 6 months
• October 26, 2022

"Made slight positive improvement, but I lost a lot of length. Now, the penis looks stubby. Very unhappy!! I went from being well-endowed to looking pitiful. Grrrrrrrrr!!"

• CR2...
• Taken for 1 to 6 months
• September 20, 2022

"Wasted lots of time and lots of money. At the end of the day, the condition got worse. Probably a combination of the drug and the provider. Bottom line: stay away."

• Did...
• Taken for 1 to 6 months
• November 20, 2019

"Went through 2 cycles of shots. My 30-degree bend turned into a 90-degree bend. Sex is impossible now."

• Tim...
• July 26, 2022

"I went through the entire series of 8 shots and no change to my 70-degree upward curve, just pain and bruising."

• Kei...
• Taken for 6 months to 1 year
• February 29, 2020

"I went through 3 sets of injections. They came out with the bill before the last set of injections: $51,000 dollars and didn’t help at all."