Skip to main content

Acetylcysteine User Reviews & Ratings

Brand names: NAC, Acetadote, N-A-C Sustain Legubeti

Acetylcysteine has an average rating of 7.3 out of 10 from a total of 32 reviews on Drugs.com. 71% of reviewers reported a positive experience, while 20% reported a negative experience.

Reviews for Acetylcysteine

  • Cat-L...
  • Taken for 1 to 6 months
  • March 4, 2023

NAC (acetylcysteine) for Dietary Supplementation "I'm female, mid-30's. Started taking this when I had COVID as I am prone to developing ARDS. I read that NAC can help boost immunity and repress inflammatory overreaction. I did not develop ARDS. I can't say for certain that the NAC prevented it. I will say, however, that wheezing and chest tightness stopped, fever went down, and I began to recover within 24 hours of starting the NAC. I stopped taking it for a while. Later I started taking daily for 4-6 months. Stopped recently due to medical issues. Results: 1) (neutral) At last 2 med checkups BP was 95/66 and 106/60 (usual 125/80) 2) (negative) Started having severe palpitations, iron deficiency worsened, odd results on metabolic panel. 3) (positive) I did not catch stomach flu or colds that others in my home had"

7 / 10
Was this helpful?YesNo
25 Report
  • allmy...
  • November 19, 2011

Mucomyst (acetylcysteine) for Expectoration "I started using acetylcysteine last May. For the first time in 20 years my lungs were clear. My bronchitis disappeared. My FEV1 increased 25 per cent. My sinus condition cleared up and the headaches were gone. I do not understand why this medicine is not used routinely for COPD and other respiratory ailments."

10 / 10
Was this helpful?YesNo
143 Report
  • Anonymous
  • Taken for less than 1 month
  • September 5, 2022

NAC (acetylcysteine) for Dietary Supplementation "Gave me bad acid reflux, coughing and I later found out it exacerbates asthma, had me so sick. Will never take again. Also read online NAC exacerbated tumor growth in lung cancer and melanoma. It may help some, but if you gave asthma be cautious. Wish I read before taking. Don't let the good reviews fool you."

2 / 10
Was this helpful?YesNo
25 Report

Frequently asked questions

  • TLD...
  • Taken for less than 1 month
  • May 8, 2013

Mucomyst (acetylcysteine) for Expectoration "I had severe bronchitis from a sinus infection while traveling. It was causing me severe pulmonary distress. I was taking my rescue inhaler every 2 hours. The doctor in Hungary prescribed acetylcysteine, to help clear the lungs. My lungs cleared in days. What a difference! The only side effect I had was dripping from my nose. It liquified the mucus there too. Usually back home in the US they prescribe steroids (prednisone) and albuterol nebulizer treatments for weeks while the coughing clears. No more for me."

10 / 10
Was this helpful?YesNo
87 Report
  • Elise
  • Taken for less than 1 month
  • September 23, 2023

NAC (acetylcysteine) for Dietary Supplementation "I've now been taking NAC 650 mg in the evening for 2 weeks. I suffer from chronic depression and generalized anxiety. It helps to stabilize my mood and it definitely helps with anxiety. I thought I should perhaps take a small break and yesterday I skipped the pill. I woke up feeling quite sad and in couple of hours the anxiety started to get stronger. I gave up the idea of a break and took one NAC pill right away. After a while I felt a lot lighter. What surprised me is that my singing voice suddenly improved a lot. I have suffered from voice issues. I think NAC helps with acid reflux, lungs and mucous membranes. Also anxiety and stress relief helps. I hope this doesn't wear off, as all the other supplements have done, so far."

9 / 10
Was this helpful?YesNo
8 Report

Are you taking this medicine?

  • Rose
  • Taken for less than 1 month
  • February 20, 2024

NAC (acetylcysteine) for Dietary Supplementation "I had taken NAC a few years ago to help repair damage in my body caused by taking the very strong antibiotic cipro. It helped to restore cell damage and I tolerated it well. With the flu hitting close to home, I decided to take it again as a prevention, but within a few days I started having terrible acid reflux and just a feeling of unwellness."

5 / 10
Was this helpful?YesNo
1 Report
  • richard
  • Taken for 6 months to 1 year
  • August 16, 2022

NAC (acetylcysteine) for Dietary Supplementation "I take this for COPD I am wheezing constantly after regular use of NAC cysteine, it helps a little reducing mucus, but creating a difficulty in breathing and wheezing daily . whereas this did not happen before taking this drug , l revert back to MSM powder with vitamin C liquid and feel better ."

3 / 10
Was this helpful?YesNo
14 Report
  • fourt...
  • Taken for 1 to 6 months
  • August 21, 2023

NAC (acetylcysteine) "This is the best. I had breathing issues, always winded, couldn't walk up stairs without losing my breath. They were going to put me on an inhaler. They all cost $300.00 and up. So my lung specialist told me to try this. Oh my god, it was amazing! My breathing started to get back to normal, I felt great, and I didn't sit around. I started to exercise cardio again for 1 hour. I started losing weight, my breathing got better, my coughing stopped, and my depression left. I felt so happy, everything that was wrong went away. I'm so active again, and I'm not winded. I will continue to take this. This is my miracle drug. I'm so happy I can walk my dog 4 miles again. I do everything I used to do. I am me again. Thank you. I saw bad reviews. Maybe it doesn't work for all, but it sure did for me. It took a while, but I could feel my breathing slowly getting better."

Was this helpful?YesNo
6 Report
  • Anonymous
  • June 14, 2015

Mucomyst (acetylcysteine) for Expectoration "As a heathcare professional having given Mucomyst to patients over more than 30 year career, I've yet to observe any benefit from the aerosolization of this med. I don't want to minimize the previous comments. Used during a bronchoscopy in liquid wash, it will dissolve thick mucus quickly and effectively but the benefit of aerosolization has not been demonstrated or established in any controlled study. Also, after more than 24 hours of use, the lung tissue will begin to "weep," this is a very caustic substance to lung. Too often it's order for a specific problem area of the lung. As the laws of nature take effect in that gas follows the path of least resistance, Mucomyst is delivered to all areas of lung with minimal effect to the problem."

1 / 10
Was this helpful?YesNo
48 Report
  • Polly
  • Taken for less than 1 month
  • February 3, 2021

For Expectoration "Acetylcysteine in the form of ACC200 has been very important in my recovery from COVID19. The chest X-Ray during hospitalization showed quite a lot of covid damage to the lungs. I have been taking 1x ACC200 x tid. It has definitely helped to clear my lungs of mucous. I am very grateful to have the benefits of acetylcysteine in my long road to recovery from a terrible case of Covid19."

10 / 10
Was this helpful?YesNo
19 Report
  • vini
  • Taken for 1 to 6 months
  • September 20, 2020

For Expectoration "I am suffering from chronic sinusitis for at least 60 years I went through lavage every two weeks in my teen age years, I had sinus surgery and different medications to include antibiotics, steroids and more, nothing made a difference. Today I am taking the Acetylcysteine 200 mg tablets lemon flavor called Reolin 3 times a day. It is made in Germany and I got it in Israel. I am feeling much better it clears the mucus and my breathing is better. It is not a cure but this is the best help I had so far."

9 / 10
Was this helpful?YesNo
19 Report
  • JSano
  • Taken for less than 1 month
  • May 14, 2019

For Expectoration "I purchased acetylcysteine over the counter from a pharmacy in Barcelona Spain in December 2018. I had chronic bronchitis that was aggravated by a cold or respiratory condition. This miracle drug stopped my coughing soon after taking it. Now in 2019 I have chronic bronchitis and it is the only thing that clears up my coughing and makes me feel better too. I don't understand why they discontinued it in the U.S. when you can purchase it all over Europe."

10 / 10
Was this helpful?YesNo
24 Report
  • happy...
  • Taken for 2 to 5 years
  • March 26, 2023

NAC (acetylcysteine) "In my late 70's I had Atrial fibrillation (A-fib) daily for a year or two. I tried NAC, and starting the next day I had not one episode of A-fib. I have been taking NAC (specifically Swanson N-Acetyl-L Cysteine) every day for over two years with mostly positive results against A-fib. I still occasionally have a bout of it, mostly mild and short-lived. No negatives to report."

10 / 10
Was this helpful?YesNo
7 Report
  • Relie...
  • November 7, 2013

For Expectoration "I had severe bronchitis while traveling in the south of France this summer and had an excellent experience with the French socialized health system. A local doctor in a small village in Provence prescribed Exomuc (an orange flavored granular form of Acetylcysteine made to be taken orally when dissolved in a small glass of water). My cough was gone within 48 hours! Why is this not a commonly prescribed drug in the US? I normally take steroids, decongestants and cough formulas for 1-2 weeks in the U.S.!"

10 / 10
Was this helpful?YesNo
40 Report
  • the_c...
  • June 24, 2011

For Expectoration "It helped my asthma a lot, diminishing the cough quite a lot. I didn't get any bronchospasm from it despite the warnings, however some itching appeared but soon went away. Before my asthma was under control it also helped a lot by making the mucus much easier to cough up. It works very well every single day (if a stop taking it the coughing soon enough increases)."

10 / 10
Was this helpful?YesNo
40 Report
  • NancyM
  • Taken for 6 months to 1 year
  • March 26, 2018

NAC (acetylcysteine) "I' ve been taking 1800 mg/day of acetylcysteine for CFS (Chronic fatigue syndrome) or myalgic encephalomyelitis (ME) symptoms and it is the single best supplement I’ve found. Dosage based on CFS study. Half life is only 3 hours, so timed release is most helpful, tho more expensive and only one brand available at this time."

9 / 10
Was this helpful?YesNo
21 Report
  • Femal...
  • Taken for 2 to 5 years
  • October 14, 2022

NAC (acetylcysteine) for Dietary Supplementation "I've taken it off and on for a few years, for its antioxidant effects initially, and the past couple years for lung support, as my asthma tries to blossom into COPD. I take 600mg once daily. Seems to help, doesn't hurt, with one exception. If I take it daily more than a couple weeks, it aggravates a pain in my left calf that is also aggravated by consuming generous amounts of smoked meat (yes, really.) My doc has no idea what's up with any of this, but isn't worried. My present hypothesis is nitrogen sticking with endothelial tissue in a vein. Oh, ageing is SUCH fun!"

8 / 10
Was this helpful?YesNo
7 Report
  • Anonymous
  • November 12, 2009

For Expectoration "When I came down with pneumonia while living in Israel, acetylcysteine (brand name Siran) made all of the difference. The medicine came as effervescent tablets with a lemon flavoring taken with water four times a day. Within 48 hours I could feel a world of difference as I started to purge all of the fluid and congestion from my lungs. Siran is one of the most effective medicines for expectoration I have ever used."

10 / 10
Was this helpful?YesNo
39 Report
  • Avid...
  • Taken for 2 to 5 years
  • January 12, 2017

For Expectoration "Personally, taking 600mg. orally bid (or tid if symptomatic) for allergic bronchitis has reduced overall severity of seasonal exacerbations. Have recommended it to others with chronic sinus or respiratory conditions where it's indicated, and most of the time, reports are very favorable. A safe older drug that is largely neglected in the U.S. Recent trial in China showed decreased hospitalizations in persons with COPD who are maintained on N-acetylcysteine."

8 / 10
Was this helpful?YesNo
19 Report
  • Fight
  • Taken for less than 1 month
  • February 6, 2019

For Expectoration "I have COPD, NAC was recommended by a friend. Started taking about 3 weeks ago. Got a sinus infection, my pulmonologist could not believe my breathing remained clear. Diagnosed 2 years ago, for me that best thing yet. Before had a few clear breathing days, now more clear than cloudy."

10 / 10
Was this helpful?YesNo
14 Report
  • tpsyc...
  • Taken for less than 1 month
  • January 10, 2015

For Expectoration "Got over the counter for severe respiratory congestion while traveling in Bruges, Belgium in 2012. Extremely and quickly effective. Will obtain additional supply in March 2015 when returning to Belgium. No adverse effects."

10 / 10
Was this helpful?YesNo
21 Report
  • Franky
  • Taken for 6 months to 1 year
  • March 14, 2020

For Expectoration "I have severe COPD and am prescribed Acetylcysteine 10% 4 ml solution. It works great for me loosening up my phlegm. The only issue with it here in Delaware County, Pennsylvania is that not one Pharmacy can obtain it. There is a shortage."

10 / 10
Was this helpful?YesNo
10 Report
  • Noddy
  • Taken for less than 1 month
  • February 21, 2022

For Expectoration "I am a recovering lung cancer survivor with COPD, GERD, TBM and severe eosinophilia asthma. I was given vials for inhalation to clear the mucus from my lungs. After using this one time I became acutely ill and unable to breath. I cannot stop coughing and I feel so heavy in my chest I can’t even breath. I don’t understand how this could happen but I need medical assistance after 2 days of this I feel like I could be the end of me. Going to ER."

1 / 10
Was this helpful?YesNo
6 Report
  • Anonymous
  • May 19, 2010

Mucomyst-10 (acetylcysteine) for Acetaminophen Overdose "It was really early in the morning, and I went to take Tylenol, when I misread the directions. I meant to measure out two tablespoons of the drug, but accidentally used my measuring cup instead. I ended up chugging two cups of Tylenol instead! I was rushed to the hospital and given Mucomyst-10 to offset the effects. Mucomyst-10 saved my life. Thank you Mucomyst-10!"

9 / 10
Was this helpful?YesNo
23 Report
  • Froike
  • Taken for 6 months to 1 year
  • December 20, 2023

"After an almost fatal bout with COVID in 2019, I developed Sinusitis/Bronchitis. This recurred several times between 2020-2022. I was treated with Corticosteroids, Immunosuppressants, you name it... NOTHING helped. I remembered that many years ago, when I was stationed in Israel, I had sinus/bronchitis problems. I was prescribed effervescent N-Acetylcysteine which helped me. I started taking this again in 2023. Within weeks, most of my symptoms of wheezing and coughing improved. Now, whenever I have sinus problems/bronchitis, this is the go-to medication! This stuff works, but only in the effervescent form."

9 / 10
Was this helpful?YesNo
1 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.