Peripheral Artery Disease

Medically reviewed by Drugs.com. Last updated on Apr 6, 2025.

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Peripheral artery disease (PAD) is narrow, weak, or blocked arteries that prevents blood flow to your legs and arms. It may affect any arteries outside of your heart and brain. PAD is usually the result of a buildup of fat and cholesterol, also called plaque, along your artery walls. Inflammation, a blood clot, or abnormal cell growth could also block your arteries. You are at risk for an amputation if poor blood flow keeps wounds from healing or causes gangrene (tissue death). Without treatment, PAD can also cause a heart attack or stroke.

DISCHARGE INSTRUCTIONS:

Call your local emergency number (911 in the US) if:

• You have any of the following signs of a heart attack:
  • Squeezing, pressure, or pain in your chest
  • You may also have any of the following:
    • Discomfort or pain in your back, neck, jaw, stomach, or arm
    • Shortness of breath
    • Nausea or vomiting
    • Lightheadedness or a sudden cold sweat
• You have any of the following signs of a stroke:
  • Numbness or drooping on one side of your face
  • Weakness in an arm or leg
  • Confusion or difficulty speaking
  • Dizziness, a severe headache, or vision loss

Seek care immediately if:

• You have sores or wounds that will not heal.
• You notice black or discolored skin on your arm or leg.
• Your skin is cool to the touch.

Drugs used to treat this and similar conditions

Treatment options

The following list of medications are related to or used in the treatment of this condition.

• Plavix
• metoprolol
• tranexamic acid
• clopidogrel
• warfarin

Call your doctor if:

• You have leg pain when you walk ⅛ mile (200 meters) or less, even with treatment.
• Your legs are red, dry, or pale, even with treatment.
• You have questions or concerns about your condition or care.

Manage PAD:

• Walk for 30 to 60 minutes at least 4 times a week. Your healthcare provider may also refer you to a supervised exercise program. The program helps increase how far you can walk without pain. It also helps you stay active in normal daily activities.
• Do not smoke. Nicotine and other chemicals in cigarettes and cigars can worsen PAD. They can also increase your risk for a heart attack or stroke. Ask your provider for information if you currently smoke and need help to quit. E-cigarettes or smokeless tobacco still contain nicotine. Talk to your provider before you use these products.
• Manage any other health conditions you have. Take your medicines as directed and follow your provider's instructions if you have high blood pressure or high cholesterol. Check your blood sugar levels as directed if you have diabetes.
• Eat heart-healthy foods. Eat whole grains, fruits, and vegetables every day. Limit salt and high-fat foods. Ask your provider for more information on a heart healthy diet. Ask what a healthy weight is for you. Your provider can help you create a healthy weight-loss plan, if needed.
• Check your feet each day. You may not be able to feel a cut or sore, or shoes that are too tight. Check your whole foot for wounds, corns, and calluses. Do not ignore small problems, such as dry skin or small wounds. These can become life-threatening without proper care. A foot specialist may need to cut your toenails, care for wounds, or remove corns. Your provider may tell you how often to see the specialist.

Medicines:

You may need any of the following:

• Antiplatelets , such as aspirin, help prevent blood clots. Take your antiplatelet medicine exactly as directed. These medicines make it more likely for you to bleed or bruise. If you are told to take aspirin, do not take acetaminophen or ibuprofen instead.
• Statin medicine helps lower your cholesterol and prevents PAD from getting worse.
• Antihypertensives may be used to help lower your blood pressure.
• Take your medicine as directed. Contact your healthcare provider if you think your medicine is not helping or if you have side effects. Tell your provider if you are allergic to any medicine. Keep a list of the medicines, vitamins, and herbs you take. Include the amounts, and when and why you take them. Bring the list or the pill bottles to follow-up visits. Carry your medicine list with you in case of an emergency.

Follow up with your doctor as directed:

Write down your questions so you remember to ask them during your visits.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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