Generic Name: Ziv-Aflibercept (Systemic) (ziv a FLIB er sept)
Brand Name: Zaltrap
Medically reviewed by Drugs.com. Last updated on Mar 1, 2019.
- Severe bleeding has happened with Zaltrap (ziv-aflibercept (systemic)). Sometimes, this has been deadly. If you are bleeding or have bleeding problems, talk with your doctor.
- Call your doctor right away if you have any signs of bleeding problems, like bruising; black, tarry, or bloody stools; bleeding gums; blood in the urine; coughing up blood; cuts that take a long time to stop bleeding; feel dizzy; feeling very tired or weak; nosebleeds; pain or swelling; throwing up blood or throw up that looks like coffee grounds; or very bad headache.
- Very bad and sometimes deadly holes in the GI (gastrointestinal) tract or fistulas have happened with Zaltrap (ziv-aflibercept (systemic)). Talk with the doctor.
- This medicine may affect how wounds heal. If you need to have surgery, you may need to stop Zaltrap (ziv-aflibercept (systemic)) before surgery. Start taking it again after surgery as you have been told by your doctor. Talk with your doctor.
Uses of Zaltrap:
- It is used to treat colorectal cancer.
What do I need to tell my doctor BEFORE I take Zaltrap?
- If you have an allergy to ziv-aflibercept or any other part of Zaltrap (ziv-aflibercept (systemic)).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you are breast-feeding or plan to breast-feed.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Zaltrap (ziv-aflibercept (systemic)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Zaltrap?
- Tell all of your health care providers that you take Zaltrap (ziv-aflibercept (systemic)). This includes your doctors, nurses, pharmacists, and dentists.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- If diarrhea or throwing up happens, talk with the doctor. You will need to make sure to avoid dehydration and electrolyte problems.
- High blood pressure has happened with Zaltrap (ziv-aflibercept (systemic)). Have your blood pressure checked as you have been told by your doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Have your urine checked as you have been told by your doctor.
- If you are 65 or older, use Zaltrap (ziv-aflibercept (systemic)) with care. You could have more side effects.
- This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. Talk with the doctor.
- If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during treatment and for 3 months after your last dose.
- If you are a man and your sex partner gets pregnant while you take Zaltrap (ziv-aflibercept (systemic)) or within 3 months after your last dose, call your doctor right away.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Use birth control to prevent pregnancy while taking Zaltrap (ziv-aflibercept (systemic)) and for 3 months after the last dose.
- If you get pregnant while taking Zaltrap (ziv-aflibercept (systemic)) or within 3 months after your last dose, call your doctor right away.
How is this medicine (Zaltrap) best taken?
Use Zaltrap (ziv-aflibercept (systemic)) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
- Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Swelling, warmth, numbness, change of color, or pain in a leg or arm.
- Chest pain or pressure.
- Shortness of breath.
- Redness or irritation of the palms of hands or soles of feet.
- Very bad belly pain.
- A very bad and sometimes deadly brain problem called posterior reversible encephalopathy syndrome (PRES) has happened with Zaltrap (ziv-aflibercept (systemic)). Call your doctor right away if you have signs like feeling confused, lowered alertness, change in eyesight, loss of eyesight, seizures, or very bad headache.
What are some other side effects of Zaltrap?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Stomach pain or diarrhea.
- Weight loss.
- Feeling tired or weak.
- Not hungry.
- Mouth irritation or mouth sores.
- Change in voice.
- Change in color of skin.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Zaltrap?
- If you need to store Zaltrap (ziv-aflibercept (systemic)) at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Zaltrap (ziv-aflibercept (systemic)), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Zaltrap (ziv-aflibercept)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- Drug class: VEGF/VEGFR inhibitors
- FDA Approval History