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Tazemetostat

Generic Name: Tazemetostat (TAZ e MET oh stat)
Brand Name: Tazverik

Medically reviewed by Drugs.com. Last updated on Oct 10, 2019.

Uses of Tazemetostat:

What do I need to tell my doctor BEFORE I take Tazemetostat?

  • If you are allergic to tazemetostat; any part of tazemetostat; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with tazemetostat, like certain drugs that are used for HIV, infections, or seizures. There are many drugs that must not be taken with tazemetostat.
  • If you are breast-feeding. Do not breast-feed while you take tazemetostat and for 1 week after your last dose.

This is not a list of all drugs or health problems that interact with tazemetostat.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take tazemetostat with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Tazemetostat?

  • Tell all of your health care providers that you take tazemetostat. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • High triglyceride levels have happened with tazemetostat. Tell your doctor if you have ever had high triglyceride levels.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • Avoid grapefruit and grapefruit juice.
  • If you have upset stomach, throwing up, diarrhea, or are not hungry, talk with your doctor. There may be ways to lower these side effects.
  • Second cancers have happened in people taking tazemetostat. If you have questions, talk with the doctor.
  • Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control like a condom while taking tazemetostat and for some time after the last dose. Ask your doctor how long to do this.
  • This medicine may cause harm to an unborn baby. A pregnancy test will be done before you start tazemetostat to show that you are NOT pregnant.
  • Women must use birth control while taking tazemetostat and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.
  • Men with a partner who may get pregnant must use birth control while taking tazemetostat and for some time after the last dose. Ask your doctor how long to use birth control. If your partner gets pregnant, call the doctor right away.

How is this medicine (Tazemetostat) best taken?

Use tazemetostat as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • Swallow whole. Do not chew, break, or crush.
  • Keep taking tazemetostat as you have been told by your doctor or other health care provider, even if you feel well.
  • If you throw up after taking a dose, do not repeat the dose. Take your next dose at your normal time.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
  • Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
  • Signs of skin infection like oozing, heat, swelling, redness, or pain.
  • Fever, chills, or sore throat.
  • Shortness of breath.
  • Bone pain.
  • Pale skin.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Tell your doctor if you have signs of high or low blood sugar like breath that smells like fruit, dizziness, fast breathing, fast heartbeat, feeling confused, feeling sleepy, feeling weak, flushing, headache, more thirsty or hungry, passing urine more often, shaking, or sweating.

What are some other side effects of Tazemetostat?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling tired or weak.
  • Constipation, diarrhea, stomach pain, upset stomach, throwing up, or feeling less hungry.
  • Headache.
  • Weight loss.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Tazemetostat?

  • Store at room temperature in a dry place. Do not store in a bathroom.
  • Protect from heat.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time tazemetostat is refilled. If you have any questions about tazemetostat, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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