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Tazemetostat Side Effects

Medically reviewed by Last updated on Oct 12, 2020.

For the Consumer

Applies to tazemetostat: oral tablets

Side effects include:

Epithelioid sarcoma: Pain, fatigue, nausea, decreased appetite, vomiting, constipation, anemia, lymphocytopenia.

Follicular lymphoma: Fatigue, upper respiratory tract infection, musculoskeletal pain, nausea, abdominal pain, lymphocytopenia, hyperglycemia, leukopenia, neutropenia, thrombocytopenia, anemia.

For Healthcare Professionals

Applies to tazemetostat: oral tablet


Very common (10% or more): Hemoglobin decreased (49%), decreased lymphocytes (36%), white blood cell count decreased (19%), hemorrhage (e.g., wound hemorrhage, rectal hemorrhage, pulmonary hemorrhage, hemorrhage intracranial, cerebral hemorrhage, hemoptysis) (18%), anemia (16%), partial thromboplastin time increased (15%)[Ref]


Very common (10% or more): Triglycerides increased (36%), glucose increased (33%), sodium decreased (30%), phosphate decreased (28%), anorexia (26%), albumin decreased (23%), alkaline phosphatase increased (23%), potassium decreased (20%), weight loss (16%), calcium decreased (16%), glucose decreased (16%), potassium increased (12%)[Ref]


Very common (10% or more): Aspartate aminotransferase increased (18%), alanine aminotransferase increased (14%)[Ref]


Uncommon (0.1% to 1%): Secondary malignancies (e.g., myelodysplastic syndrome [MDS], acute myeloid leukemia [AML])[Ref]


Very common (10% or more): Cough (18%), dyspnea/dyspnea exertional (16%)[Ref]


Very common (10% or more): Pain (e.g., tumor pain, pain in extremity, non-cardiac chest pain, flank pain, back pain, arthralgia, bone pain, cancer pain, musculoskeletal pain, myalgia, neck pain) (52%), fatigue/asthenia (47%)[Ref]


The most common adverse reactions (20% or greater) were pain, fatigue, nausea, decreased appetite, vomiting, and constipation.[Ref]

Nervous system

Very common (10% or more): Headache (18%)[Ref]


Very common (10% or more): Creatinine increased (14%)[Ref]


Very common (10% or more): Nausea (36%), vomiting (24%), constipation (21%), diarrhea (16%), abdominal pain (13%)[Ref]


1. "Product Information. Tazverik (tazemetostat)." Epizyme, Inc, Cambridge, MA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.