Tazemetostat Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 24, 2024.

Applies to tazemetostat: oral tablet.

Serious side effects of tazemetostat

Along with its needed effects, tazemetostat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tazemetostat:

More common side effects

• bladder pain
• bleeding gums
• bloody or cloudy urine
• body aches or pain
• chest pain or tightness
• cough
• coughing up blood
• difficult, burning, or painful urination
• difficulty in breathing or swallowing
• dizziness
• ear congestion
• fever or chills
• frequent urge to urinate
• headache
• increased menstrual flow or vaginal bleeding
• loss of voice
• lower back or side pain
• muscle or bone pain
• nosebleeds
• pale skin
• prolonged bleeding from cuts
• red or black, tarry stools
• red or dark brown urine
• redness, itching, pain, swelling, tenderness, or warmth on the skin
• sneezing
• sore throat
• stuffy or runny nose
• unusual bleeding or bruising
• unusual tiredness or weakness

Less common side effects

• confusion
• fast heartbeat
• lightheadedness or fainting
• painful blisters on the trunk of the body
• rapid, shallow breathing

Rare side effects

• general feeling of illness
• hoarseness
• sores, ulcers, or white spots on the lips or in the mouth
• swollen glands
• weight loss
• yellow skin and eyes

Other side effects of tazemetostat

Some side effects of tazemetostat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• constipation
• decreased appetite
• diarrhea
• hair loss or thinning
• nausea or vomiting
• skin rash
• stomach pain

For healthcare professionals

Applies to tazemetostat: oral tablet.

General adverse events

The most common adverse reactions (20% or greater) were pain, musculoskeletal pain, abdominal pain, fatigue, nausea, decreased appetite, vomiting, upper respiratory tract infection, and constipation.^[Ref]

Dermatologic

• Very common (10% or more): Alopecia (17%), rash (15%)
• Common (1% to 10%): Herpes zoster^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (36%), vomiting (24%), constipation (21%), diarrhea (16%), abdominal pain (e.g., abdominal discomfort, abdominal pain, abdominal pain lower, abdominal pain upper) (13%)^[Ref]

Genitourinary

• Very common (10% or more): Urinary tract infection (e.g., cystitis, urinary tract infection, urinary tract infection staphylococcal) (11%)^[Ref]

Hematologic

• Very common (10% or more): Hemoglobin decreased (49%), decreased lymphocytes (36%), white blood cell count decreased (19%), hemorrhage (e.g., wound hemorrhage, rectal hemorrhage, pulmonary hemorrhage, hemorrhage intracranial, cerebral hemorrhage, hemoptysis) (18%), anemia (16%), partial thromboplastin time increased (15%)^[Ref]

Hepatic

• Very common (10% or more): Aspartate aminotransferase increased (18%), alanine aminotransferase increased (14%)^[Ref]

Metabolic

• Very common (10% or more): Triglycerides increased (36%), glucose increased (33%), sodium decreased (30%), phosphate decreased (28%), anorexia (26%), albumin decreased (23%), alkaline phosphatase increased (23%), potassium decreased (20%), weight loss (16%), calcium decreased (16%), glucose decreased (16%), potassium increased (12%), decreased appetite (26%)^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (e.g., back pain, limb discomfort, musculoskeletal chest pain, musculoskeletal discomfort, musculoskeletal pain, myalgia, neck pain, non-cardiac chest pain, pain in extremity, pain in jaw, spinal pain) (22%)^[Ref]

Nervous system

• Very common (10% or more): Headache (e.g., headache, migraine, sinus headache) (18%)^[Ref]

Oncologic

• Uncommon (0.1% to 1%): Secondary malignancies (e.g., myelodysplastic syndrome [MDS], acute myeloid leukemia [AML])^[Ref]

Other

• Very common (10% or more): Pain (e.g., tumor pain, pain in extremity, non-cardiac chest pain, flank pain, back pain, arthralgia, bone pain, cancer pain, musculoskeletal pain, myalgia, neck pain) (52%), fatigue/asthenia (47%), pyrexia (10%)
• Common (1% to 10%): Sepsis^[Ref]

Renal

• Very common (10% or more): Creatinine increased (14%)^[Ref]

Respiratory

• Very common (10% or more): Cough/productive cough (18%), dyspnea/dyspnea exertional (16%), upper respiratory tract infection (e.g., laryngitis, nasopharyngitis, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, viral upper respiratory tract infection) (30%), lower respiratory tract infection (e.g., bronchitis, lower respiratory tract infection, tracheobronchitis) (17%)
• Common (1% to 10%): Pneumonia^[Ref]

Further information

Tazemetostat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer