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Tazemetostat Side Effects

Medically reviewed by Last updated on Dec 19, 2023.

Applies to tazemetostat: oral tablet.

Serious side effects of Tazemetostat

Along with its needed effects, tazemetostat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tazemetostat:

More common

Less common


Other side effects of Tazemetostat

Some side effects of tazemetostat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to tazemetostat: oral tablet.


The most common adverse reactions (20% or greater) were pain, musculoskeletal pain, abdominal pain, fatigue, nausea, decreased appetite, vomiting, upper respiratory tract infection, and constipation.[Ref]


Very common (10% or more): Alopecia (17%), rash (15%)

Common (1% to 10%): Herpes zoster[Ref]


Very common (10% or more): Nausea (36%), vomiting (24%), constipation (21%), diarrhea (16%), abdominal pain (e.g., abdominal discomfort, abdominal pain, abdominal pain lower, abdominal pain upper) (13%)[Ref]


Very common (10% or more): Urinary tract infection (e.g., cystitis, urinary tract infection, urinary tract infection staphylococcal) (11%)[Ref]


Very common (10% or more): Hemoglobin decreased (49%), decreased lymphocytes (36%), white blood cell count decreased (19%), hemorrhage (e.g., wound hemorrhage, rectal hemorrhage, pulmonary hemorrhage, hemorrhage intracranial, cerebral hemorrhage, hemoptysis) (18%), anemia (16%), partial thromboplastin time increased (15%)[Ref]


Very common (10% or more): Aspartate aminotransferase increased (18%), alanine aminotransferase increased (14%)[Ref]


Very common (10% or more): Triglycerides increased (36%), glucose increased (33%), sodium decreased (30%), phosphate decreased (28%), anorexia (26%), albumin decreased (23%), alkaline phosphatase increased (23%), potassium decreased (20%), weight loss (16%), calcium decreased (16%), glucose decreased (16%), potassium increased (12%), decreased appetite (26%)[Ref]


Very common (10% or more): Musculoskeletal pain (e.g., back pain, limb discomfort, musculoskeletal chest pain, musculoskeletal discomfort, musculoskeletal pain, myalgia, neck pain, non-cardiac chest pain, pain in extremity, pain in jaw, spinal pain) (22%)[Ref]

Nervous system

Very common (10% or more): Headache (e.g., headache, migraine, sinus headache) (18%)[Ref]


Uncommon (0.1% to 1%): Secondary malignancies (e.g., myelodysplastic syndrome [MDS], acute myeloid leukemia [AML])[Ref]


Very common (10% or more): Pain (e.g., tumor pain, pain in extremity, non-cardiac chest pain, flank pain, back pain, arthralgia, bone pain, cancer pain, musculoskeletal pain, myalgia, neck pain) (52%), fatigue/asthenia (47%), pyrexia (10%)

Common (1% to 10%): Sepsis[Ref]


Very common (10% or more): Creatinine increased (14%)[Ref]


Very common (10% or more): Cough/productive cough (18%), dyspnea/dyspnea exertional (16%), upper respiratory tract infection (e.g., laryngitis, nasopharyngitis, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, viral upper respiratory tract infection) (30%), lower respiratory tract infection (e.g., bronchitis, lower respiratory tract infection, tracheobronchitis) (17%)

Common (1% to 10%): Pneumonia[Ref]


1. Product Information. Tazverik (tazemetostat). Epizyme, Inc. 2020.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.