Skip to Content

Symfi

Generic Name: Efavirenz, Lamivudine, and Tenofovir Disoproxil Fumarate (e FAV e renz la MI vyoo deen & ten OF oh vir dye soe PROX il FUE ma rate)
Brand Name: Symfi, Symfi Lo

Medically reviewed on May 2, 2018

Warning

  • Hepatitis B has gotten worse when Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) was stopped in some people with hepatitis B. Close follow-up for a few months is needed when therapy is stopped in people who have hepatitis B. Do not stop taking Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) without calling your doctor. Talk with your doctor.

Uses of Symfi:

What do I need to tell my doctor BEFORE I take Symfi?

For all patients taking Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate):

  • If you have an allergy to Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) or any part of Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Kidney disease or liver disease.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate), like certain drugs that are used for hepatitis C, HIV, or infections. There are many drugs that must not be taken with Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate).
  • If you are using another drug that has the same drug in it.
  • If you are taking a drug that has sorbitol in it.
  • If you are taking any drugs that can raise the chance of kidney problems. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
  • If you are pregnant or may be pregnant. Do not take Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) if you are pregnant.
  • If you are breast-feeding. Do not breast-feed while you take Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate).

Children:

  • If your child weighs less than 77 pounds (35 kilograms).

This is not a list of all drugs or health problems that interact with Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Symfi?

  • Tell all of your health care providers that you take Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate). This includes your doctors, nurses, pharmacists, and dentists.
  • This medicine may cause you to have dizziness, sleepiness, trouble sleeping, trouble focusing, or dreams that are not normal. Most of the time, these effects go away after taking Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) for 2 to 4 weeks. It may help if you take Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) at bedtime. If you feel dizzy or sleepy, or you have trouble focusing, avoid driving and doing other tasks or actions that call for you to be alert. Call your doctor if these effects last, they bother you, or are very bad.
  • This medicine may cause high cholesterol and triglyceride levels. Talk with the doctor.
  • Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
  • This medicine is not a cure for HIV. Stay under the care of your doctor.
  • This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors. Talk with your doctor.
  • Bone problems like bone pain, soft bones, and thin bones have happened with Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate). This may lead to broken bones. You may need to have a test to check your bones. Talk with your doctor.
  • Kidney problems like kidney failure have happened with Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate). Tell your doctor if you have ever had kidney problems.
  • This medicine may rarely cause swollen liver and an acid health problem in the blood. This may be deadly in some cases. The chance may be higher in women, in overweight people, and in people who have taken drugs like this one for a long time. Talk with your doctor.
  • Changes in your immune system can happen when you start taking drugs to treat HIV. If you have an infection that you did not know you had, it may show up when you take Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate). Tell your doctor right away if you have any new signs after you start Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate), even after taking it for several months. This includes signs of infection like fever, sore throat, weakness, cough, or shortness of breath.
  • A pancreas problem (pancreatitis) has happened in children taking lamivudine with or without other HIV drugs. Sometimes this has been deadly. If you have questions, talk with the doctor.
  • Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate).
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant, especially in the first trimester.
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate). Talk with your doctor.
  • Use birth control that you can trust to prevent pregnancy while taking Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) and for 3 months after care ends.
  • If you get pregnant while taking Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) or within 3 months after your last dose, call your doctor right away.

How is this medicine (Symfi) best taken?

Use Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take on an empty stomach.
  • Taking Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) at bedtime may help with some side effects.
  • Keep taking Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) as you have been told by your doctor or other health care provider, even if you feel well.
  • It is important that you do not miss or skip a dose of Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) during treatment.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Have your urine checked as you have been told by your doctor.
  • Hepatitis B testing needs to be done as you were told by the doctor. Talk with the doctor.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate).
  • Take calcium and vitamin D as you were told by your doctor.
  • This medicine interacts with many other drugs. The chance of Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate)'s side effects may be raised or how well Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) works may be lowered. The chance of the other drugs' side effects may also be raised. This may include very bad, life-threatening, or deadly side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate) with all of your other drugs (prescription or OTC, natural products, vitamins).

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • If you are not sure what to do if you miss a dose, call your doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of too much lactic acid in the blood (lactic acidosis) like fast breathing, fast heartbeat, a heartbeat that does not feel normal, very bad upset stomach or throwing up, feeling very sleepy, shortness of breath, feeling very tired or weak, very bad dizziness, feeling cold, or muscle pain or cramps.
  • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
  • Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
  • Hallucinations (seeing or hearing things that are not there).
  • Bone pain.
  • Muscle pain or weakness.
  • Pain in arms or legs.
  • Seizures.
  • Change in body fat.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
  • A type of abnormal heartbeat (prolonged QT interval) can happen with Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate). Call your doctor right away if you have a fast heartbeat, a heartbeat that does not feel normal, or if you pass out.

What are some other side effects of Symfi?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Stomach pain.
  • Back pain.
  • Upset stomach or throwing up.
  • Loose stools (diarrhea).
  • Feeling tired or weak.
  • Joint pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Symfi?

  • Store in the original container at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Symfi (efavirenz, lamivudine, and tenofovir disoproxil fumarate), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about Symfi (efavirenz / lamivudine / tenofovir)

Consumer resources

Other brands: Symfi Lo

Professional resources

Related treatment guides

Hide