Generic Name: panitumumab (PAN-i-TOOM-ue-mab)
Brand Name: Vectibix
Skin problems like acne, itching, redness, rash, and dry or cracked skin are common with this drug. Very bad skin problems, infections, and tissue damage have also happened with this drug. Sometimes these have been life-threatening or deadly. Talk to your doctor about any skin changes you may have.
A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
Panitumumab is used for:
Treating certain types of colon or rectal cancer that have spread to other parts of the body. It may also be used for other conditions as determined by your doctor.
Panitumumab is a monoclonal antibody. It works to treat certain types of cancer by reducing the growth and survival of the cancer.
Do NOT use panitumumab if:
- you are allergic to any ingredient in panitumumab
- you have a certain gene mutation (RAS) or if it is not known if you have this type of gene mutation
Contact your doctor or health care provider right away if this applies to you.
Before using panitumumab:
Some medical conditions may interact with panitumumab. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of lung problems (eg, pulmonary fibrosis), skin problems, or eye problems
- if you have low blood calcium, magnesium, or potassium levels
- if you have diarrhea or you are dehydrated
- if you are scheduled to receive a vaccine
- if you are receiving other chemotherapy medicines (eg, bevacizumab)
Some MEDICINES MAY INTERACT with panitumumab. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Other chemotherapy medicines (eg, bevacizumab) because they may increase the risk of panitumumab's side effects
This may not be a complete list of all interactions that may occur. Ask your health care provider if panitumumab may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use panitumumab:
Use panitumumab as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Panitumumab is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
- If you miss a dose of panitumumab, contact your doctor right away.
Ask your health care provider any questions you may have about how to use panitumumab.
Important safety information:
- Tell your doctor or dentist that you take panitumumab before you receive any medical or dental care, emergency care, or surgery.
- Panitumumab often causes skin reactions. Exposure to sunlight may make this worse. Avoid the sun, sunlamps, or tanning booths while you use panitumumab and for 2 months after you stop using it. Use sunscreen and wear protective clothing if you must be outside for more than a short time.
- Severe diarrhea and dehydration have happened in patients taking panitumumab and chemotherapy. This can lead to kidney problems or other health problems. If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
- Infusion reactions can occur in patients while receiving panitumumab. Some infusion reactions have been deadly. Symptoms of an infusion reaction may include chills; dizziness or light-headedness; fainting; fever; or breathing problems. Tell your doctor if you experience any of these symptoms or other unusual effects during an infusion. Discuss the risks and benefits of using panitumumab with your doctor.
- Severe and sometimes fatal lung problems and blood clots have happened in patients treated with panitumumab. Discuss any questions or concerns with your doctor.
- People with a certain gene mutation (RAS) may not benefit from panitumumab. Their tumor may also get worse and chance of death may be increased. Discuss any questions or concerns with your doctor.
- Lab tests, including blood electrolytes, may be performed while you use panitumumab and for 8 weeks after you stop panitumumab. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Women who are able to become pregnant must use an effective form of birth control while using panitumumab. You will need to continue to use birth control while you use panitumumab and for 6 months after you stop using it. If you have questions about effective birth control, talk with your doctor.
- Men who use panitumumab should always use a condom when having sex with a woman who may become pregnant. Do this for as long as you use panitumumab and for 6 months after you stop using it.
- PREGNANCY and BREAST-FEEDING: Panitumumab may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using panitumumab while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while you use panitumumab and for 2 months after you stop using it.
Possible side effects of panitumumab:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; eyelash growth; mild acne; mild dryness, itching, or redness of the skin; nausea; stomach pain; tiredness; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); chest pain; coughing up blood; discharge from the eye; dry mouth or eyes; increased tearing; irritation, pain, redness, or swelling of the eye or eyelid; irritation, redness, swelling, or sores in or around the mouth; moderate to severe skin changes (eg, blistered, cracking, peeling, swollen, or painful skin; moderate to severe acne; moderate to severe redness or itching); new or worsening lung or breathing problems (eg, cough, shortness of breath, wheezing); pain, redness, or swelling at the injection site; pain, redness, or swelling near the nailbed; severe or persistent constipation, diarrhea, nausea, stomach pain, or vomiting; signs of infection (eg, chills, fever, sore throat); sluggishness; swelling of the ankles, feet, or hands; symptoms of low blood magnesium levels (eg, irregular heartbeat; mental or mood changes; muscle aches, cramps, pain, spasms, or weakness; seizures; tremor; loss of appetite); vision changes; weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of panitumumab:
Panitumumab will be given to you at your doctor's office, hospital, or clinic. You will not store it at home. Keep all medicines out of the reach of children and away from pets.
- If you have any questions about panitumumab, please talk with your doctor, pharmacist, or other health care provider.
- Panitumumab is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take panitumumab or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about panitumumab. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to panitumumab. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using panitumumab.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about panitumumab
- Other brands: Vectibix