Generic Name: Durvalumab (dur VAL ue mab)
Brand Name: Imfinzi
Medically reviewed on Sep 5, 2018
Uses of Imfinzi:
- It is used to treat cancer in the bladder or urinary tract.
- It is used to treat lung cancer.
What do I need to tell my doctor BEFORE I take Imfinzi?
- If you have an allergy to Imfinzi (durvalumab) or any part of Imfinzi (durvalumab).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you are breast-feeding. Do not breast-feed while you take Imfinzi (durvalumab) or for 3 months after your last dose.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Imfinzi (durvalumab) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Imfinzi?
- Tell all of your health care providers that you take Imfinzi (durvalumab). This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- If you have high blood sugar (diabetes), talk with your doctor. This medicine may raise blood sugar.
- Tell your doctor if you have signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Check your blood sugar as you have been told by your doctor.
- Very bad health problems like some organ problems can happen with Imfinzi (durvalumab). This includes lung, liver, thyroid gland, pituitary gland, adrenal gland, kidney, and muscle problems. A very bad rash may also happen. Sometimes, these problems have been deadly. These problems may happen anytime during treatment or after treatment has stopped. Talk with the doctor.
- You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
- Call your doctor right away if you have any signs of infection like fever, chills, flu-like signs, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or a wound that will not heal.
- Some people have had side effects during the infusion. Sometimes, these could be very bad or life-threatening. Tell your doctor if you have any of these side effects during the infusion: back or neck pain, chills or shaking, dizziness, feeling like passing out, fever, flushing, itching, rash, shortness of breath, swelling of the face, or wheezing.
- It is common to have loose stools (diarrhea) with Imfinzi (durvalumab). However, a very bad bowel problem (colitis) with diarrhea has happened with Imfinzi (durvalumab). This may lead to tears or holes in the bowels and may be life-threatening. Call your doctor right away if you have bloody stools; dark, tarry, or sticky stools; diarrhea; or very bad stomach pain.
- This medicine may raise the chance of a very bad brain problem called aseptic meningitis. Call your doctor right away if you have a headache, fever, chills, very upset stomach or throwing up, stiff neck, rash, bright lights bother your eyes, feeling sleepy, or feeling confused.
- Eye problems have happened with Imfinzi (durvalumab). Some types of eye problems may need to be treated right away to lower the chance of long-lasting eyesight loss. Call your doctor right away if you have any changes in eyesight, eye pain, or very bad eye irritation.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Use birth control that you can trust to prevent pregnancy while taking Imfinzi (durvalumab) and for 3 months after care ends.
- If you get pregnant while taking Imfinzi (durvalumab) or within 3 months after your last dose, call your doctor right away.
How is this medicine (Imfinzi) best taken?
Use Imfinzi (durvalumab) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
For all uses of Imfinzi (durvalumab):
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of thyroid, pituitary, or adrenal gland problems. Some signs may be change in mood or the way you act, change in weight, constipation, deeper voice, dizziness, fainting, feeling cold, feeling very tired, hair loss, headache that lasts or is very bad, or lowered interest in sex.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of lung or breathing problems like shortness of breath or other trouble breathing, cough, or fever.
- Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
- Signs of a very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in the mouth, throat, nose, or eyes.
- Any unexplained bruising or bleeding.
- Very bad muscle pain or weakness.
- Chest pain.
- A heartbeat that does not feel normal.
- Feeling very tired or weak.
- Shortness of breath, a big weight gain, or swelling in the arms or legs.
Bladder cancer treatment:
- Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
What are some other side effects of Imfinzi?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling tired or weak.
- Muscle pain.
- Bone pain.
- Hard stools (constipation).
- Not hungry.
- Upset stomach.
- Belly pain.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Imfinzi?
- If you need to store Imfinzi (durvalumab) at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Imfinzi (durvalumab), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Imfinzi (durvalumab)
- Imfinzi Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: Anti-PD-1 monoclonal antibodies