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Infigratinib

Generic name: infigratinib [ IN-fig-RA-ti-nib ]
Brand name: Truseltiq
Dosage form: oral capsule (100 mg daily-dose; 125 mg daily-dose; 50 mg daily-dose; 75 mg daily-dose)
Drug class: Multikinase inhibitors

Medically reviewed by Drugs.com on Jun 22, 2021. Written by Cerner Multum.

What is infigratinib?

Infigratinib is used to treat bile duct cancer that has an abnormal "FGFR2" gene and has spread to other parts of the body (metastatic) after other treatment, and cannot be removed with surgery. Your doctor will make sure you have the correct tumor type to be treated with infigratinib.

Infigratinib may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on the label and package. Use exactly as directed.

Before taking this medicine

Tell your doctor if you have ever had:

  • problems with your eyes or vision;

  • liver disease; or

  • kidney disease.

You may need to have a negative pregnancy test before starting this treatment.

Infigratinib can harm an unborn baby if the mother or the father is using infigratinib. Use birth control while using this medicine and for at least 1 month after your last dose.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

How should I take infigratinib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Infigratinib is given in a 28-day treatment cycle and you will take the medicine only on certain days of this cycle.

Take on an empty stomach, at least 1 hour before or 2 hours after a meal.

Take the medicine at the same time each day.

Swallow the capsule whole and do not crush, chew, break, or open it. Take with a full glass of water.

If you vomit shortly after taking infigratinib, do not take another dose. Take your next dose as scheduled.

You may need frequent vision exams. You may need to use artificial tears or lubricating eye gels if you have dry eyes.

Store tablets in the blister pack at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if you are more than 4 hours late for the dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking infigratinib?

Grapefruit may interact with infigratinib and cause side effects. Avoid consuming grapefruit products.

Avoid taking an antacid within 2 hours before or after you take infigratinib.

Infigratinib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Infigratinib may cause serious side effects. Call your doctor at once if you have:

  • eye pain or discomfort;

  • vision changes;

  • redness, swelling, pain, or blisters on the palms of your hands or the soles of your feet;

  • numbness, or tingling around your mouth;

  • muscle cramps;

  • high calcium levels--confusion, tiredness, nausea, vomiting, loss of appetite, constipation, increased thirst or urination, weight loss; or

  • low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of infigratinib may include:

  • dry eyes, blurred vision;

  • redness or tenderness on your hands or feet;

  • dry skin, hair loss, changes in your eyelashes;

  • problems with your fingernails or toenails;

  • dry mouth, mouth sores, changes in your sense of taste;

  • stomach pain, loss of appetite, vomiting, diarrhea, constipation;

  • feeling weak or tired;

  • joint pain; or

  • low blood cell counts, high calcium, or other abnormal lab tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Infigratinib dosing information

Usual Adult Dose for Cholangiocarcinoma of biliary tract:

125 mg (one 100 mg capsule and one 25 mg capsule) orally once a day for 21 days on 7 days off of a 28-day cycle

Comments:
-Continue treatment until disease progression or unacceptable toxicity.
-Select patients for the treatment of unresectable locally advanced or metastatic cholangiocarcinoma based on the presence of an FGFR2 fusion or rearrangement.
-Information on FDA-approved test(s) for the detection of FGFR2 fusions or rearrangements in cholangiocarcinoma is available at: http://www.fda.gov/CompanionDiagnostics.

Use: For the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement as detected by an FDA-approved test

What other drugs will affect infigratinib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Take your infigratinib dose 2 hours before or 10 hours after taking an "H2 blocker" stomach acid medicine. This includes cimetidine, famotidine, nizatidine, ranitidine, Pepcid, Tagamet, and Zantac.

Tell your doctor about any medicines you take to reduce stomach acid. This includes esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole, Nexium, and Prilosec.

Other drugs may affect infigratinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.