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Imfinzi Side Effects

Generic Name: durvalumab

Note: This document contains side effect information about durvalumab. Some of the dosage forms listed on this page may not apply to the brand name Imfinzi.

For the Consumer

Applies to durvalumab: intravenous solution

Along with its needed effects, durvalumab (the active ingredient contained in Imfinzi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking durvalumab:

More common
  • Bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • depressed mood
  • difficult, burning, or painful urination
  • difficulty having a bowel movement (stool)
  • dry skin and hair
  • feeling cold
  • fever
  • frequent urge to urinate
  • hair loss
  • hoarseness or husky voice
  • lower back or side pain
  • muscle cramps and stiffness
  • pain
  • rapid weight gain
  • slowed heartbeat
  • stomach cramps
  • tenderness
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • watery or bloody diarrhea
Less common
  • Chest pain
  • chills
  • cough
  • dark urine
  • difficult breathing
  • general feeling of discomfort or illness
  • general tiredness and weakness
  • light-colored stools
  • nausea and vomiting
  • nervousness
  • sensitivity to heat
  • sweating
  • thickening of bronchial secretions
  • trouble sleeping
  • upper right abdominal or stomach pain
  • weight loss
  • yellow eyes and skin
Less common or rare
  • Back, leg, or stomach pains
  • black, tarry stools
  • bleeding gums
  • bloody nose
  • blurred vision or other change in vision
  • chest tightness
  • eye redness, irritation, or pain
  • general body swelling
  • headache
  • heavier menstrual periods
  • loss of appetite
  • nosebleeds
  • pale skin
  • pinpoint red spots on the skin
  • redness of the eye
  • sensitivity of the eye to light
  • skin rash
  • sore throat
  • stiff neck or back
  • tearing
  • unusual bleeding or bruising

Some side effects of durvalumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to durvalumab: intravenous solution


Common (1% to 10%): Immune-mediated endocrinopathies (e.g., hypothyroidism, hyperthyroidism, adrenal insufficiency, type 1 diabetes mellitus, hypophysitis/hypopituitarism)[Ref]


Very common (10% or more): Rash (dermatitis, dermatitis acneiform, dermatitis psoriasiform, psoriasis, rash maculopapular, rash pruritic, rash papular, rash pustular, skin toxicity, eczema, erythema, erythema multiforme, rash erythematous, acne, lichen planus) (11%)[Ref]


Uncommon (0.1% to 1%): Immune-related myocarditis[Ref]


Very common (10% or more): Lymphopenia (11%)
Common (1% to 10%): Anemia[Ref]


Very common (10% or more): Urinary tract infection (e.g., cystitis, candiduria, urosepsis) (15%)[Ref]


Very common (10% or more): Constipation (21%), nausea (16%), abdominal pain (upper, lower, flank) (14%), diarrhea/colitis (13%)
Common (1% to 10%): Dehydration
Frequency not reported: Immune-mediated colitis[Ref]


Common (1% to 10%): Liver injury, immune-mediated hepatitis
Uncommon (0.1% to 1%): Increased ASO, increased ALT, hyperbilirubinemia
Frequency not reported: Immune-mediated hepatitis[Ref]


Very common (10% or more): Decreased appetite/hypophagia (19%), hyponatremia (12%)
Common (1% to 10%): Deterioration of general physical health, increased alkaline phosphatase, hypermagnesemia, hypercalcemia, hyperglycemia, neutropenia, hyperkalemia, hypoalbuminemia[Ref]


Common (1% to 10%): Infusion-related reactions[Ref]


Common (1% to 10%): Infections (e.g., sepsis, necrotizing fasciitis, osteomyelitis)[Ref]


Uncommon (0.1% to 1%): Uveitis and keratitis[Ref]


Very common (10% or more): Musculoskeletal pain (e.g., back pain, musculoskeletal chest pain, musculoskeletal pain and discomfort, myalgia, neck pain) (24%)[Ref]

Nervous system

Common (1% to 10%): Pyrexia/tumor associated fever
Uncommon (0.1% to 1%): Immune-related aseptic meningitis[Ref]


Very common (10% or more): Fatigue (e.g., asthenia, lethargy, malaise) (39%), peripheral edema (e.g., edema, localized edema, edema peripheral, lymphedema, peripheral swelling, scrotal edema, scrotal swelling) (15%), pyrexia/tumor associated fever (14%)
Common (1% to 10%): Embryofetal toxicity[Ref]


Common (1% to 10%): Acute kidney injury, increased creatinine[Ref]


Very common (10% or more): Dyspnea/exertional dyspnea (24%), cough/productive cough (10%)
Uncommon (0.1% to 1%): Immune-mediated pneumonitis[Ref]


1. "Product Information. Imfinzi (durvalumab)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.

Some side effects of Imfinzi may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.