Imfinzi Side Effects

Generic name: durvalumab

Medically reviewed by Drugs.com. Last updated on Nov 5, 2023.

Note: This document provides detailed information about Imfinzi Side Effects associated with durvalumab. Some dosage forms listed on this page may not apply specifically to the brand name Imfinzi.

Applies to durvalumab: intravenous solution.

Serious side effects of Imfinzi

Along with its needed effects, durvalumab (the active ingredient contained in Imfinzi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking durvalumab:

Other side effects of Imfinzi

Some side effects of durvalumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to durvalumab: intravenous solution.

Endocrine adverse events

• Common (1% to 10%): Immune-mediated endocrinopathies (e.g., hypothyroidism, hyperthyroidism, adrenal insufficiency, type 1 diabetes mellitus, hypophysitis/hypopituitarism)^[Ref]

Dermatologic

• Very common (10% or more): Rash (dermatitis, dermatitis acneiform, dermatitis psoriasiform, psoriasis, rash maculopapular, rash pruritic, rash papular, rash pustular, skin toxicity, eczema, erythema, erythema multiforme, rash erythematous, acne, lichen planus) (11%)^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Immune-related myocarditis^[Ref]

Hematologic

• Very common (10% or more): Lymphopenia (11%)
• Common (1% to 10%): Anemia^[Ref]

Genitourinary

• Very common (10% or more): Urinary tract infection (e.g., cystitis, candiduria, urosepsis) (15%)^[Ref]

Gastrointestinal

• Very common (10% or more): Constipation (21%), nausea (16%), abdominal pain (upper, lower, flank) (14%), diarrhea/colitis (13%)
• Common (1% to 10%): Dehydration
• Frequency not reported: Immune-mediated colitis^[Ref]

Hepatic

• Common (1% to 10%): Liver injury, immune-mediated hepatitis
• Uncommon (0.1% to 1%): Increased ASO, increased ALT, hyperbilirubinemia
• Frequency not reported: Immune-mediated hepatitis^[Ref]

Metabolic

• Very common (10% or more): Decreased appetite/hypophagia (19%), hyponatremia (12%)
• Common (1% to 10%): Deterioration of general physical health, increased alkaline phosphatase, hypermagnesemia, hypercalcemia, hyperglycemia, neutropenia, hyperkalemia, hypoalbuminemia^[Ref]

Local

• Common (1% to 10%): Infusion-related reactions^[Ref]

Immunologic

• Common (1% to 10%): Infections (e.g., sepsis, necrotizing fasciitis, osteomyelitis)^[Ref]

Ocular

• Uncommon (0.1% to 1%): Uveitis and keratitis^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (e.g., back pain, musculoskeletal chest pain, musculoskeletal pain and discomfort, myalgia, neck pain) (24%)^[Ref]

Nervous system

• Common (1% to 10%): Pyrexia/tumor associated fever
• Uncommon (0.1% to 1%): Immune-related aseptic meningitis^[Ref]

Other

• Very common (10% or more): Fatigue (e.g., asthenia, lethargy, malaise) (39%), peripheral edema (e.g., edema, localized edema, edema peripheral, lymphedema, peripheral swelling, scrotal edema, scrotal swelling) (15%), pyrexia/tumor associated fever (14%)
• Common (1% to 10%): Embryofetal toxicity^[Ref]

Renal

• Common (1% to 10%): Acute kidney injury, increased creatinine^[Ref]

Respiratory

• Very common (10% or more): Dyspnea/exertional dyspnea (24%), cough/productive cough (10%)
• Uncommon (0.1% to 1%): Immune-mediated pneumonitis^[Ref]

Frequently asked questions

• What type of drug is Imfinzi?

Further information

Imfinzi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer