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Erivedge

Generic Name: vismodegib (VIS-moe-DEG-ib)
Brand Name: Erivedge

Erivedge may cause serious birth defects and/or fetal death if taken during pregnancy. Women who either take Erivedge or are sexual partners of men who take Erivedge must have a negative pregnancy test within 7 days before therapy with Erivedge is started. Women who take Erivedge must use effective birth control while taking it and for 7 months after Erivedge is stopped. Men who take Erivedge must use condoms with spermicide as birth control while taking it and for 2 months after Erivedge is stopped. If you think you or your sexual partner may be pregnant, contact your doctor right away.


Erivedge is used for:

Certain types of skin cancer in certain patients. It may also be used for other conditions as determined by your doctor.

Erivedge is a hedgehog signaling pathway inhibitor. It works by blocking certain substances in the body, which kills certain cancer cells.

Do NOT use Erivedge if:

  • you are allergic to any ingredient in Erivedge

Contact your doctor or health care provider right away if any of these apply to you.

Before using Erivedge:

Some medical conditions may interact with Erivedge. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are able to become pregnant or father a child

Some MEDICINES MAY INTERACT with Erivedge. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Azithromycin, clarithromycin, or erythromycin because they may increase the risk of Erivedge's side effects
  • Antacids, H2-receptor blockers (eg, famotidine), or proton pump inhibitors (PPIs) (eg, omeprazole) because they may decrease Erivedge's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Erivedge may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Erivedge:

Use Erivedge as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Erivedge comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Erivedge refilled.
  • Take Erivedge by mouth with or without food.
  • Swallow Erivedge whole. Do not open, break, crush, or chew before swallowing.
  • If you miss a dose of Erivedge, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Erivedge.

Important safety information:

  • Women who take Erivedge must use effective birth control while taking it and for 7 months after Erivedge is stopped. Talk with your doctor about what birth control method is best for you.
  • Men who take Erivedge, even those who have had a vasectomy, must use condoms with spermicide as birth control while taking it and for 2 months after Erivedge is stopped.
  • Women who either take Erivedge or are sexual partners of men who take Erivedge must have a pregnancy test within 7 days before therapy with Erivedge is started.
  • Talk with your doctor right away if you have unprotected sex or if you think that your birth control has failed.
  • Do not donate blood or blood products while you take Erivedge and for at least 7 months after your last dose of Erivedge to prevent exposure through a blood transfusion to a pregnant woman.
  • Erivedge should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Erivedge may cause serious birth defects and/or fetal death if taken during pregnancy. Do not become pregnant while you are using it. If you think you or your sexual partner may be pregnant while you are taking Erivedge or during the 7 months after your last dose of Erivedge, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Erivedge.

Possible side effects of Erivedge:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; hair loss; joint pain; loss of appetite; loss of taste or other taste changes; muscle spasms; nausea; tiredness; vomiting; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); absent menstrual period; decreased urination; symptoms of low blood potassium levels (eg, muscle pain, weakness, or cramping; irregular heartbeat); symptoms of low blood sodium levels (eg, confusion, mental or mood changes, seizures, sluggishness).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Erivedge:

Store Erivedge at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Erivedge out of the reach of children and away from pets.

General information:

  • If you have any questions about Erivedge, please talk with your doctor, pharmacist, or other health care provider.
  • Erivedge is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Erivedge or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Erivedge. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Erivedge. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Erivedge.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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