Generic Name: Bosutinib (boe SUE ti nib)
Brand Name: Bosulif
Uses of Bosutinib:
- It is used to treat a type of leukemia.
What do I need to tell my doctor BEFORE I take Bosutinib?
- If you have an allergy to bosutinib or any other part of bosutinib.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with bosutinib, like certain drugs that are used for HIV, infections, or seizures. There are many drugs that must not be taken with bosutinib.
- If you are taking St. John's wort. Do not take St. John's wort with bosutinib. This medicine may not work as well.
- If you are breast-feeding. Do not breast-feed while you take bosutinib or for 1 month after you stop bosutinib.
This is not a list of all drugs or health problems that interact with bosutinib.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take bosutinib with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Bosutinib?
- Tell all of your health care providers that you take bosutinib. This includes your doctors, nurses, pharmacists, and dentists.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- It is common to have diarrhea, upset stomach, throwing up, or stomach pain with bosutinib. Call your doctor if any of these side effects get very bad, bother you, or do not go away.
- If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- Do not try to treat diarrhea without first checking with your doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- If you need to take an antacid or a drug like famotidine or ranitidine, talk with your doctor about how to take it while taking bosutinib.
- Avoid grapefruit and grapefruit juice.
- This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. Talk with the doctor.
- This medicine may cause harm to the unborn baby or loss of the unborn baby if you take it while you are pregnant.
- If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting bosutinib. Talk with your doctor.
- Use birth control that you can trust to prevent pregnancy while taking bosutinib and for at least 1 month after stopping bosutinib.
- If you get pregnant while taking bosutinib or within 1 month after your last dose, call your doctor right away.
How is this medicine (Bosutinib) best taken?
Use bosutinib as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with food.
- Swallow whole. Do not chew, break, or crush.
- To gain the most benefit, do not miss doses.
- Keep taking bosutinib as you have been told by your doctor or other health care provider, even if you feel well.
- You will need to take special care when handling bosutinib. Check with the doctor or pharmacist to see how to handle bosutinib.
- If the tablet is crushed or broken, do not touch the contents. If you do touch the contents or get it in your eyes, wash hands or eyes right away.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it, with food.
- If it has been 12 hours or more since the missed dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Signs of dehydration like dry skin, mouth, or eyes; thirst; fast heartbeat; dizziness; fast breathing; or confusion.
- Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
- Passing urine more often.
- Feeling very tired or weak.
- Chest pain.
- Shortness of breath.
- Weight gain.
- Ringing in ears.
What are some other side effects of Bosutinib?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling tired or weak.
- Belly pain.
- Not hungry.
- Upset stomach or throwing up.
- Loose stools (diarrhea).
- Joint pain.
- Back pain.
- Signs of a common cold.
- Nose and throat irritation.
- Change in taste.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Bosutinib?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer Information Use and Disclaimer
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Disclaimer: This information should not be used to decide whether or not to take bosutinib or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about bosutinib. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to bosutinib. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using bosutinib.
Review Date: February 7, 2018
More about bosutinib
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 3 Reviews – Add your own review/rating
- Drug class: BCR-ABL tyrosine kinase inhibitors
Other brands: Bosulif