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Blinatumomab

Generic Name: blinatumomab (BLIN-a-TOOM-oh-mab)
Brand Name: Blincyto

A severe and sometimes fatal health problem called cytokine release syndrome (CRS) has happened in patients getting blinatumomab. Call your doctor right away if you have chills, dizziness, fainting, fever, headache, nausea, rash, swelling of the face, tiredness, trouble breathing or wheezing, vomiting, or weakness.

Nerve problems have happened in patients getting blinatumomab. Sometimes, nerve problems have been fatal. Call your doctor right away if you have confusion, loss of balance, passing out, seizures, or speech problems (eg, slurred speech).


Blinatumomab is used for:

Treating a certain type of acute lymphoblastic leukemia (ALL). It may also be used for other conditions as determined by your doctor.

Blinatumomab is a CD19-directed CD3 T-cell engager. It helps the body to kill certain cancer cells.

Do NOT use blinatumomab if:

  • are allergic to any ingredient in blinatumomab

Contact your doctor or health care provider right away if any of these apply to you.

Before using blinatumomab:

Some medical conditions may interact with blinatumomab. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an infection, kidney problems, or liver problems
  • if you have a history of nerve problems (eg, confusion, loss of balance, seizures, speech problems)
  • if you have a history of an infusion reaction after receiving blinatumomab or other medicines

Some MEDICINES MAY INTERACT with blinatumomab. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cyclosporine or warfarin because the risk of their side effects may be increased by blinatumomab

This may not be a complete list of all interactions that may occur. Ask your health care provider if blinatumomab may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use blinatumomab:

Use blinatumomab as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Blinatumomab comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get blinatumomab refilled.
  • Blinatumomab will be given as an infusion at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
  • Another medicine will be given before blinatumomab to help with infusion side effects. Talk with your doctor.
  • Do not throw away any of blinatumomab in your trash. Follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
  • If you miss a dose of blinatumomab, call your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use blinatumomab.

Important safety information:

  • Blinatumomab may cause dizziness, seizures, or confusion. Do not drive or perform other possibly unsafe tasks while getting blinatumomab. Discuss any questions or concerns with your doctor.
  • Blinatumomab may lower the ability of your body to fight infection. Serious and sometimes fatal infections have happened in people getting blinatumomab. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • A serious and possibly fatal condition called tumor lysis syndrome (TLS) has been reported in certain patients taking blinatumomab. Contact your doctor right away if you develop symptoms such as fast or irregular heartbeat; fainting; decreased urination; muscle weakness or cramps; nausea, vomiting, diarrhea, or loss of appetite; or sluggishness. Discuss any questions or concerns with your doctor.
  • It is important to keep the area around where blinatumomab goes into the body clean. This will help reduce the risk of infection. Discuss any questions or concerns with your doctor.
  • Follow the directions doctor gives you about how to use your pump closely. Do not change the settings on your pump. If there is a problem with your pump or if an alarm sounds, call your doctor or nurse right away.
  • Diabetes patients - Blinatumomab may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lab tests may be performed while you use blinatumomab. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use blinatumomab with caution in the ELDERLY; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: Blinatumomab may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using blinatumomab while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking blinatumomab.

Possible side effects of blinatumomab:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Arm or leg pain; back, bone, or joint pain; constipation; decreased appetite; diarrhea; stomach pain; trouble sleeping; weight gain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; wheezing); chest pain; shortness of breath; swelling of the hands, ankles, or feet; symptoms of high blood sugar (eg, confusion; drowsiness; flushing; fruit-like breath odor; increased thirst, hunger, or urination; rapid breathing); symptoms of infection (eg, fever, chills, sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal); symptoms of low potassium levels (eg, irregular heartbeat; muscle cramps, pain, or weakness); tremor; unusual bruising or bleeding; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of blinatumomab:

Blinatumomab is usually handled and stored by a health care provider. If you receive blinatumomab in a special package at home, do not open the package. Store blinatumomab as directed by your pharmacist or health care provider. The package that contains blinatumomab will be opened by your health care provider. Keep blinatumomab out of the reach of children and away from pets.

General information:

  • If you have any questions about blinatumomab, please talk with your doctor, pharmacist, or other health care provider.
  • Blinatumomab is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take blinatumomab or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about blinatumomab. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to blinatumomab. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using blinatumomab.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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