Generic Name: Blinatumomab (blin a TOOM oh mab)
Brand Name: Blincyto
Medically reviewed on July 4, 2018
- A very bad and sometimes deadly health problem called cytokine release syndrome (CRS) has happened in people getting blinatumomab. Call your doctor right away if you have chills, dizziness, feeling tired or weak, fever, headache, passing out, rash, swelling of the face, trouble breathing, upset stomach or throwing up, or wheezing.
- Nerve problems have happened in people getting blinatumomab. Sometimes, these nerve problems have been deadly. Call your doctor right away if you have confusion, headache, loss of balance, passing out, seizures, speech problems like slurred speech, or trouble sleeping. Call your doctor right away if you have trouble with face movements, hearing, eyesight, or swallowing.
Uses of Blinatumomab:
- It is used to treat a type of leukemia.
What do I need to tell my doctor BEFORE I take Blinatumomab?
- If you have an allergy to blinatumomab or any part of blinatumomab.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you are breast-feeding. Do not breast-feed for at least 48 hours after getting blinatumomab.
Children (7-day infusion):
- If your child weighs less than 22 kilograms (48 pounds). Do not give blinatumomab to a child who weighs less than 22 kilograms (48 pounds).
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take blinatumomab with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Blinatumomab?
- Tell all of your health care providers that you take blinatumomab. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for alertness while you take blinatumomab. Talk with your doctor.
- You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
- Talk with your doctor if you have recently had a vaccine or before getting any vaccines. Vaccine use with blinatumomab may either raise the chance of an infection or make the vaccine not work as well.
- Be sure to keep the area around where blinatumomab goes into the body clean. This will help lower the chance of infection. Talk with the doctor.
- Follow what the doctor tells you about how to use the pump closely. Do not change the settings on the pump. If there is a problem with the pump or if an alarm sounds, call the doctor or nurse right away.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking blinatumomab with your other drugs.
- Use with care in children. Talk with the doctor.
- If you are 65 or older, use blinatumomab with care. You could have more side effects.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting blinatumomab. Talk with your doctor.
- Use birth control that you can trust to prevent pregnancy while taking blinatumomab and for at least 48 hours after your last dose.
- If you get pregnant while taking blinatumomab or within 48 hours after your last dose, call your doctor right away.
Children (7-day infusion):
- This medicine has benzyl alcohol in it. Benzyl alcohol may cause very bad and sometimes deadly side effects in newborns or infants. Talk with the doctor.
How is this medicine (Blinatumomab) best taken?
Use blinatumomab as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- Other drugs may be given to help with infusion side effects.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of high or low blood pressure like very bad headache or dizziness, passing out, change in eyesight.
- Signs or symptoms of depression, suicidal thoughts, emotional ups and downs, abnormal thinking, anxiety, or lack of interest in life.
- Chest pain or pressure.
- Shortness of breath.
- Any unexplained bruising or bleeding.
- Feeling very tired or weak.
- Swollen gland.
- Memory problems or loss.
- Feeling very sleepy.
- Yellow skin or eyes.
- Patients with cancer who take blinatumomab may be at a greater risk of getting a bad health problem called tumor lysis syndrome (TLS). Sometimes, this has been deadly. Call your doctor right away if you have a fast heartbeat or a heartbeat that does not feel normal; any passing out; trouble passing urine; muscle weakness or cramps; upset stomach, throwing up, loose stools, or not able to eat; or feel sluggish.
- Very bad and sometimes deadly pancreas problems (pancreatitis) have happened with blinatumomab. Call your doctor right away if you have very bad stomach pain, very bad back pain, or very upset stomach or throwing up.
What are some other side effects of Blinatumomab?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Pain in arms or legs.
- Back pain.
- Bone pain.
- Weight gain.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Blinatumomab?
- Most of the time, blinatumomab will be given in a hospital or doctor's office. If stored at home, follow how to store as you were told by the doctor.
- If you get blinatumomab in a special package at home, do not open the package. The package will be opened by the doctor.
- Do not throw away any of blinatumomab in the trash. Follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time blinatumomab is refilled. If you have any questions about blinatumomab, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about blinatumomab
- Blinatumomab Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 0 Reviews
- Drug class: miscellaneous antineoplastics
Other brands: Blincyto