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Atovaquone and Proguanil

Generic Name: Atovaquone and Proguanil (a TOE va kwone & pro GWA nil)
Brand Name: Malarone

Medically reviewed by Last updated on Oct 9, 2020.

Uses of Atovaquone and Proguanil:

  • It is used to treat or prevent malaria.

What do I need to tell my doctor BEFORE I take Atovaquone and Proguanil?

  • If you have an allergy to atovaquone, proguanil, or any other part of atovaquone and proguanil.
  • If you are allergic to atovaquone and proguanil; any part of atovaquone and proguanil; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have kidney problems.
  • If you are taking any of these drugs: Rifabutin or rifampin.

This is not a list of all drugs or health problems that interact with atovaquone and proguanil.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take atovaquone and proguanil with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Atovaquone and Proguanil?

For all uses of atovaquone and proguanil:

  • Tell all of your health care providers that you take atovaquone and proguanil. This includes your doctors, nurses, pharmacists, and dentists.
  • Liver problems have happened with atovaquone and proguanil. Sometimes these problems have been severe, leading to liver transplant or death. Liver problems may happen in people with or without liver disease. Talk with the doctor.
  • If you are throwing up or have diarrhea, atovaquone and proguanil may not work as well. Talk with your doctor.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

Preventing malaria:

  • Other measures are needed along with atovaquone and proguanil including using screens, bed netting, insect repellent (10% to 35% DEET), and permethrin spray on clothing and nets. Avoid spraying most insect repellents on children. Lower evening and night-time outdoor activity.
  • If you are a pregnant woman and traveling to a malaria infested place, talk to your doctor about the risks first.

How is this medicine (Atovaquone and Proguanil) best taken?

Use atovaquone and proguanil as ordered by your doctor. Read all information given to you. Follow all instructions closely.

For all uses of atovaquone and proguanil:

  • Take atovaquone and proguanil at the same time of day.
  • Take with food or a milky drink.
  • Keep taking atovaquone and proguanil as you have been told by your doctor or other health care provider, even if you feel well.
  • If you throw up within 1 hour of taking atovaquone and proguanil, take 1 more dose.
  • You may crush the tablet and mix it with condensed milk.
  • After mixing, take your dose right away. Do not store for future use.

Preventing malaria:

  • Use as you have been told to prevent malaria.
  • If using to prevent malaria, start atovaquone and proguanil before traveling to the high risk place.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

For all uses of atovaquone and proguanil:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Strange or odd dreams.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

Preventing malaria:

  • Fever that happens while in or after coming back from the malaria area.

What are some other side effects of Atovaquone and Proguanil?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Cough.
  • Stomach pain or diarrhea.
  • Upset stomach or throwing up.
  • Not hungry.
  • Feeling tired or weak.
  • Dizziness.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Atovaquone and Proguanil?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about atovaquone and proguanil, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.