I have suffered from fibromyalgia for 27 years... been on multiple antidepressants and an ungodly number of supplements... nothing really helps except tramadol which takes the edge off. Decided to break down and try Lyrica in spite of the fact the main side effect is weight gain and I am already obese... I was not obese when I began having symptoms but in a period of 4 years my weight doubled!! Thyroid meds have not helped. Anyway.. I am taking 50mg of lyrica twice a day... it's only been a few days but I don't really notice any difference so I was wondering for people who have had positive results how long did it take to feel a difference and at what dosage? Thanks and God bless you.