I am a fibromyalgia sufferer in Australia and have been diagnosed 3+ years ago and am now aged 59. I take a myriad of medications and have had to change my GP and chemist to my house locality due to the expense of getting to my previous GP and chemist. The main regime of meds I am on is 225mg of Effexor XR (anti-depressant); Lyrica BD, SR tramadol 50mg BD; Panadol Osteo 2tabs/3xdaily(for TMJ dysfunction (arthritis in jaw); and when required 50mg Tramadol Fast acting up to 3 times daily. My new doctor says I am functioning very well for taking all that medication over a long period (2.5yrs+) and apart from trying to get into see a pain management specialist to review the meds and how I cope(lovely long wait list) I have occasionally had to take oxycodone as well. Dry Needling occasionally helps but after 6 visits in the year it costs me too much. Swimming/Physio in thermal pool no good as it triggers severe pain in hips. Best thing I have found is learning about my medical condition and adjusting my life to live with it mainly not overdoing anything, bit hard when I am still raising grandchildren but I manage thanks to these meds. I advocate listening to medical professionals about medication because it can afford you a better quality of life in my opinion.
The question I would like to ask is about the combination of this medication regime esp Lyrica and tramadol having long term side effects (What studies have been done) and is there ever going to be any hope that my seratonin level can recover? I am aware of the possibilities of liver damage but in the scheme of things in our world we live in we are bound to get damage to that anyway. I do my best to eat majority of home cooked meals with loads of veggies etc and supplement with B12 and magnesium.
Thank you for the time you have taken to read my post and I look forward to seeing some helpful responses to my medication query.
Thanks and regards
Long term side effects of Lyrica and tramadol for pain management in fibromyalgia?
Question posted by Debinoz on 25 Oct 2022
Last updated on 24 July 2023 by mfpdfibro
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3 Answers
I am sorry that I can’t give you any great advice on the long term effects of Lyrica and Tramodal, but I take Gabapentin/Neurontin, which is similar. I have been on it for at least 15 years and have never had any issues or problems because of it. I did switch over to Lyrica at one point, but it made my ankles swell profusely, so I went back to the Gabapentin. Personally, not trying to scare you, but I would be more concerned about the long term effects of taking Effexor and Tramadol. Both medications are similar in that they both have an SSRI seratonin re-uptake inhibitors & a NPRI noraprinephrine re-uptake inhibitors in them. Plus it sounds like you sometimes take an additional dose of quick release tramadol.
So there is a thing called Seratonin Syndrome, which you should look up to see the symptoms of, In addition, my personal experience, which I understand that everyone is different, but with you taking two different NPRI’s, I just can’t imagine you being able to ever stop taking them. I have no desire to alarm you, because you could easily have absolutely no difficulty coming off of those meds, but I will never do it again. I have a much easier time coming off of opiates than I do with noraprinephrine re-uptake inhibitors. So I would say that the long term effects would be that you would have to be on them the rest of your life. Outside of the difficulty of getting off of them, NPRI haven’t been out long enough to find any long term studies. Same with Lyrica, pretty new. If you can get onto the EBSCO HOST MASTER FILE, an electronic database that covers anything printed on any subject and found in the states on-line, but through the library, you can look up anything and everything on anything and everything. Best of luck to you and I hope to have helped a little.
I’m 77 years old and have been taking tramadol HCL ER for 20 years with no problems. I tried Lyrica, but it doesn’t help me. Over the years l have tried all the standard drugs used for fibromyalgia. Only two have ever helped: tramadol and amitriptyline.
As I can't answer the majority of your questions , I can answer a couple... only from my experience.
I was on Tramadol 50mgx6 daily for 3 years. I ended up having really bad seizures and wound up in the emergency room twice from Tramadol. These man made drugs help for a short time, but then they start causing all sorts of problems. If I were you I would start weaning yourself off off of Tramadol and look into holistic healing... more natural elements that can support your pain. I suffer from a traumatic brain injury and have chronic pain as well as cognitive struggles... but I can say I am relieved that I am no longer attached to Tramadol. All the best to you. Your questions you do have are more aimed towards a professional in my opinion.
Cheers
J
Related topics
lyrica, depression, anxiety, pain, fibromyalgia, tramadol, chronic pain, side effect, medication, pain management, neuropathic pain, management
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