How long did it take for anyone to feel a change when you started taking Trintellix?

Hi All,
I started the Trintellix a week ago at 10mg. I take it at bedtime, but still have some queasy stomach feelings during the day. Only just starting to feel a small glimmer of hope. I'm 56, have RA, and restless leg syndrome. My sleep isn't great, though I've not noticed that my legs are any more restless than normal. I took dopamine medications for more than 20 years and had to stop taking them the beginning of the year as they were causing a lot of anxiety and depression. I sure hope this drug helps, I'm really tired of being sad and anxious. I need some hope.

Like some others, I had an almost immediate positive reaction, feeling calm, stable, and able to concentrate. Then today (day7), i woke up knowing it would be a bad day. Feeling very physically and mentally shaky, irritable, unable to concentrate. By end of day had migraine and now I can't sleep. That is not common for me. Hoping it is just part of the process of adjustment.

I started taking 5 mg yesterday and I am so sensitive to chemicals I started to notice it the same day. Within 4 hours of taking it. I felt a sense of calmness and overall clarity. I don't think I was manic but I was really excited I felt good and could concentrate and wasn't so irritable and sad. I slept great and woke up refreshed. No panic attacks in almost 24 hours!!! I could do without the gas though... but hopefully it will go away in 2 weeks. So far no nausea. I am a nurse so I worry about low sodium levels but I can be on the look out for these I guess. I did develop somewhat of an itch in my chin 40 mn after I took it so I hope there is no allergic reaction for me with this especially if it works! My psych MD diagnosed me with MDD and major GAD. I thought I was some type of bi polar. I guess if I take it again and feel manic I will know and I will try a bi polar med.

I am a 76-year-old woman. I took my first dose last evening. I took half of a 5 mg tablet as I am very sensitive to medications. Unbelievably, this morning I am feeling a difference. I only hope it lasts! I feel a calmness that I don’t remember feeling before and I actually am also feeling less depressed. I did some exercises early in the morning that I usually have to push myself to finally do late in the day. Also I’m having some positive thoughts that I haven’t had in a long time. I have bipolar 2 and am hoping I am not going to get hypomanic which the brochure does mention can happen to some people. Will post again later to give an update. I hope this is helpful.

I'm now finished 2 weeks on 10 mgs, yesterday I caught myself laughing like I used to. I'm supposed to go up to 20 mgs tomorrow, not sure I will. It did take 2 weeks to notice a definite difference, but after a week I started to feel a little calmer and settled each day. It'll be nice to feel even more better at 4 weeks!

Hi, Seascape! Although people do sometimes report feeling better sooner, just so you know, it can sometimes take as long as 4-6 weeks to really feel the full benefit of an antidepressant/anxiolytic. Unlike most other types of medications that work right away, you need to allow time for psych drugs to build up to therapeutic blood levels.
Try to be patient during this time and think positively. Enjoy the times you're feeling better and if you backslide a little or have a bad day... don't dwell on it. Things will be better soon!

It took 2 weeks before I started to feel less sad, less weepy, and less anxious. I started with 5 mg and took it for 3 weeks before increasing to 10 mg (just finished week 1 of 10 mg). Had stomach discomfort and gas for the first 2 weeks before they went away. Now after 4 weeks total I can honestly say I do feel somewhat better. I don't know if my doctor will increase my dosage or not.