How Does Vistogard Work?
- Asked
- 9 Mar 2016
- Active
- 9 Mar 2016
- Topics
- faq, vistogard, fluorouracil overdose, capecitabine overdose
Answers (1)
Official Answer by Drugs.com
9 Mar 2016
Vistogard (uridine triacetate) oral granules is an antidote for the emergency treatment of adult and pediatric patients following an overdose of the chemotherapy agents 5-fluorouracil (5-FU) or capecitabine.
A metabolite of fluorouracil, FUTP, blocks DNA replication and repair. Uridine, from uridine triacetate, competitively inhibits cell damage and cell death caused by fluorouracil.
It is not known if Vistogard is safe and effective if started more than 4 days (96 hours) after the end of a dose of fluorouracil or capecitabine.
Further Information
- Vistogard Information for Consumers
- Vistogard Information for Healthcare Professionals (includes dosage details)
- Side Effects of Vistogard (detailed)
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