How Does Vistogard Work?

Vistogard (uridine triacetate) oral granules is an antidote for the emergency treatment of adult and pediatric patients following an overdose of the chemotherapy agents 5-fluorouracil (5-FU) or capecitabine.

A metabolite of fluorouracil, FUTP, blocks DNA replication and repair. Uridine, from uridine triacetate, competitively inhibits cell damage and cell death caused by fluorouracil.

It is not known if Vistogard is safe and effective if started more than 4 days (96 hours) after the end of a dose of fluorouracil or capecitabine.