Someone mentioned that in a Gabapentin thread and its got me wondering now.
Lyrica is FDA approved for fybromyalgia, gabapentin is not. Gabapentin is used for several off-label areas such as nerve pain and fibromyalgia. Lyrica is also used for some off-label areas. Drug companies cannot advertise for anything not approved by the FDA, but doctors can still prescribe off-label for other areas. There are some technical differences in how they work. Gabapentin is nonlinear and Lyrica is linear in dose-response relationship. Lyrica dosages are thought to have more predictability in the effect on the body. Gabapentin dosages are thought by some to be more unpredictable in relation to effect. Some think a higher gabapentin dosage may actual have less effect than lower dosages. Being nonlinear, some think gabapentin results vary more from person to person.
Leaning more toward conspiracy theory, some think when Pfizer's patent expired on Neurontin, so a generic gabapentin could be sold, they came up with a "better" option that would make more money than a drug that had a generic competitor. Pfizer was still the sole seller of the generic under their subsidiary Greenstone, but in 2004, Teva in Israel was licensed to sell the generic. In 2004, Lyrica was developed. Some think that coincidence is suspicious. There are valid differences between the two drugs, but some still feel the system is flawed.
They are different drugs but they are like cousins. Lyrica has one less carbon atom in the molecule. This makes the structure more open. Lyrica is absorbed quicker and longer. However, both gabapentin and pregabalin(Lyrica) work the same way. They attach to a specific sub-unit protien and buffer the calcium ions in the voltage gated calcium channels. This is where nerves are activated.
Both drugs were developed by the same company but pregabalin was invented by a researcher in conjunction with Park-Davis.
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I take 200mg lyrica 3 times a day for fibermyalga, also neuropathy, what mg of gabapentin do I take?
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