Im a 25 year old male and iv taken Zoloft about two years ago for my social anxiety and it worked for about a month then did the complete opposite and made me more nervous then before. Also i recently tried Lexapro and the first day i took it, it was unbearable for me, it made me extremely nervous and scared to the point that i couldn't communicate or socialize with anyone because of it. im not so much depressed but my anxiety around others is terrible. iv just been proscribed effexor and before i take it i want to make sure that it wont make me feel like lexapro made me feel like.
Effexor XR - How is Effexor better then Lexapro or Zoloft?
Question posted by kjrobertson13 on 9 Oct 2012
Last updated on 14 March 2017
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8 Answers
Been on Effexor XR 75mg at least 10 years and for the rest of my life. More recently its generic: Venlafaxine ER 75mg, much less expensive. I take it for a physical condition called Cataplexy, a step child of the sleep disorder Narcolepsy. It has perfectly solved my problems there. I also experienced a genuine 'smoothing out' of my type A personality as well. I would often over-react to things in daily life but had no real depression. It has evened out my rough edges and I'm lost without it. Absolutely zero side effects experienced which I am most thankful for. All I can say is it's perfect for me, hope you find the same.
I am a 45-year-old male and have been on antidepressants since junior year of college. In 1990, I was diagnosed with mild depression and anxiety about school, and was prescribed Prozac.
When I relocated for work after college, I got a new doctor, and a new antidepressant which was Celexa.
I was on that for what seemed like forever and then my doctor decided to put me on Lexapro.
I noticed little difference between Celexa and Lexapro, what Cipro may be a tad better.
All three of the medications I mentioned had very little side effects.
In December 2014 I was rushed to the hospital with multiple medical issues. I was acutely depressed because of these health issues and ensuing battle, so the psychiatrist at the hospital put me on Effexor in lieu of Lexa.
His reasoning was that Effexor (Venlafaxine) works not only on serotonin, but also on norepinephrine. These are important chemicals in your brain that regulate and manage your mood and outlook on life. It is a medicine that you start low and increase dosage every two days until you are at your "comfortable cruising altitude". The normal for an average size male is 150 mg, which is where I stopped. There are negative side effects in the first several days mainly diarrhea upset stomach but you can tell that it is temporary and transient. Those side effects go away completely and at cruising altitude, I would say that it is slightly better than Lexapro.
If you are on Lexapro and are 80% there and are seeking the other 20% I don't recommend switching to Effexor to try to get that last 20%.
I hope this helps, and I empathize with you greatly. Best of luck. David
I've been on almost every medication there is for depression and I've gone back to effexor because it really works with less side effects . I take 5mg of abilify and 300 effexor er.Its important to remind yourself too that no medicine can cure it but only relieve symptoms good luck
Unfortunatley there is no 'better' antidepressant, however some antidepressents are more effective for anxiety than others, they are more anxiolytic. These are Paroxetine, Sertraline, Fluoxamine and Esciralopram. Paxil in particular is very effective for GAD in studies whilst Zoloft is for SAnD. Effexor is an incredibly good antidepressant but not really a good anxiolytic in a lot of people.
For Anxiety I'd rather Paxil or Zoloft. Zoloft is actually partially a SDRI AT HIGH DOSES.
I have been taking Effexor for a number of years. Not only did it get rid of my depression but also my anxiety and panics. Some anti depressants suit some people and not others, so it is a matter of trying until you find one that suits you. Now Effexor suits me, but might not suit you.
Also bear in mind Effexor is very difficult to withdraw from.
As Kiasmama has explained Effexor does affect two brain chemical were as Lexapro and Zoloft only one. Unfortunately, finding the right medication is a trail and error sort of ordeal as what works for one won't for another. Not one size fits all. Also, quite often the side effects in the beginning are discouraging to say the least, but if you can push through they will subside within the first couple of weeks and the medication will begin to work and reach maximum effectiveness around the one month mark. We can't guarantee that Effexor will not make you feel like the Lexapro made you feel. There are other antidepressants for anxiety that are possibilities which I would remember if the Effexor isn't the one. In particular Paxil and Celexa are often prescribed for anxiety disorder. You may also benefit from short-term use of a benzodiazepine. Just be aware they are addictive and can cause rebound anxiety when discontinued. You must taper off when you stop taking any of these medication so to avoid withdrawal effects.
Hello kjrobertson13. Its not really. To add a word of caution that Effexor can cause high blood pressure. Regards pledge
Morning Pledgy. How have you been? Coffee is ready and danish fresh from the oven, lol. Enjoy this crisp fall weather and have a great day.
Morning Miss Laurie & Pledge. Would be happy to join you for a good hot cuppa this morning., & I'll bring the donuts...
Good morning Ladies. Yes, enjoying the cooler weather. Long time in arriving. Enjoy the cuppa, it tastes better when the temps are chilly :-0)
Morning Miss Mary. How are you feeling? Hope all is well and looking forward to a donut, yummmy. Have a wonderful day!!
I am feeling much better thank you Laurie, & you have a great day too... Mary
To kjrobertson, sorry to horn in on our question with our 'good mornings' to friends. I am very happy that iffexor is helping you. You are welcome to join us for a good hot cuppa & a sweet or two. Best wishes to you...
(this is a virtual cuppa & danish of course)
Zoloft is an ssri, a selective serotonin reuptake inhibitor. That means it increases one of the chemicals in your brain that keeps you from being depressed and/or anxious. Effexor is an snri, a serotonin and norepinephrine reuptake inhibitor, meaning it increases both the chemicals in the brain that do this.
that's great to know! thank you very much. but every time i take these drugs i get extremely nervous and that's the problem im trying to resolve. i feel like when i try and mess with my serotonin levels it ends up doing the opposite and makes me super nervous.
Sometimes they cause anxiety at first, until they are at the full effect.
I am ranting again..but SSRis affect reuptake at 2 serontonin receptors... sometimes refered to as the clean and dirty receptors..ie one has most of the positive actions the other sexual disfunction..side effects trazodone and nefazodone only effect reuptake at the clean receptors... but trazodone is a weak anti depressant and very sedating... nefazodone/Serzone not used much..good side effect profile..but for many people does not do much... I look on these two drugs as chill pills more than antidepressants..help me because I am more keyed up than depressed
Dear Kaismama:
I saw a fascinating dose response curve for Effexor..cannot vouch for its authenticity... but it looked at Effexor as "three different drugs"as you noted it affecting different neurotransmitters..
Interestingly to me..It reached its near maximum effect on serontonin about between 30 to 80mg..and was saturated for this neurotransmitter slightly higher..started kicking in for norepi around 150mg possibly dopamine around
300mg..of course this is not exact..but pointed out, unlike SSRis, this SSNR
had different effects at different dosages
Just to correct what kaismama said and add a little further information.
-Venlafaxine-
It acts as SSRI in LOW doses (75 mg/day).
It provides dual mechanism agent in MODERATE doses (150-225 mg/day)
AND it affects serotonin, norepinephrine, and dopamine in HIGH doses (375 mg/day).
Even at 150 mg (where it begins to affect serotonin), consider this: Effexor has a SE:NE (serotonin:norepinephrine) reuptake-inhibition ratio of 30:1 -- or, said simply, it's 30 times more potent on serotonin than on norepinephrine.
As an example, Cymbalta has about 10:1 ratio.
Just to clarify that Effexor is indeed an SSRI at 75mg/daily dose.
Related topics
a-25, effexor, effexor xr, lexapro, zoloft, anxiety, social anxiety disorder, generalized anxiety disorder, anxiety and stress, nervous, male
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