Anyone tried Prolia for osteoporosis? If so, did you have any side effects from it?

Next and most importantly, Prolia cannot just be stopped. You must relay off it using a bisphosphonate because Prolia has a Rebound Effect that is unique to Prolia. When you stop using it, your bones deteriorate to levels lower than they were when you started. This can result in multiple spontaneous vetebral fractures, it is not uncommon and that is because so many doctors are ignorant of the need for follow up therapy to control the Rebound Effect. It is clearly stated in Amgen's prescribing information and there is no excuse for this ignorance. Then, you must have bone turnover markers tested prior to stopping Prolia to get a baseline and then every 3 months after starting your relay medication because Rebound from Prolia can be very fierce indeed and last for 3 years.
In February this year I had an infusion of zoledronic acid (Aclasta or Reclast) to relay off Prolia. My bone turnover markers began to rise alarmingly even though I had the most powerful bisphosphonate available infused into my body. Zoledronic acid is meant to be a 12 monthly infusion, I had to have a repeat infusion at 6 months (last week) to get Rebound under control.
Lastly, dexa scans are very unreliable. At my 6 months check last week I had with me a dexa scan and the bone turnover marker tests - the dexa scan showed improvement whilst the bone turnover markers (CTx & P1NP) showed clearly that Rebound was out of control. So, the doctors who say "we'll give you a zoledronic acid infusion, or whatever bishphosphonate they decide on and follow up with a dexa scan in 12 months" are simply uneducated. I am outraged by the level of ignorance around this powerful and dangerous drug and am blessed to have found an endocrinologist who knows exactly what she's doing. You do know Prolia has a black box warning for hypocalcemia right? If you have kidney issues, perhaps you should look at that. Good luck with it.

I was about to get a knee replacement in my other knee due to the pain being caused by Prolia in January this year. Immediately before my next Prolia shot was due in February this year the pain subsided in my knee and the all over musculoskeletal pain disappeared entirely. No knee replacement required - talk about dodging a bullet. You CANNOT just stop taking Prolia, it must be followed up with a bisphosphonate to counteract the inevitable Rebound Effect which can cause multiple vertebral fractures. It's a long and expensive road, having bone turnover markers tested every 3 months to ensure Rebound is under control - I just had my 6 month blood draw and if my CTx is too high I will have to have another Aclasta infusion. Thank goodness I have an endocrinologist who understands the nature of this drug. Be very, very wary of Prolia.

Now the doctors believe that I am swollen because of the Prolia. My sister just had a prolia shot about 6 weeks ago for the 2nd time and she is now getting swollen hands and feel. I am literally counting the days until the 6 months time period for the Prolia to end. Anyone else swollen from the Prolia?

I didn't accept Prolia immediately, in fact I waited for 12 months without any more fractures but based on dexa results it was advised that I do take up the Prolia. I was 63 years old. I was led to believe that I was made of glass and would shatter into a million pieces without it. I was completely unaware of the nature of denosumab and the fact that it simply causes old, dead bone cells to be retained therefore creating an illusion of more density. It is old, dead bone and the quality of that bone is not good. I do not recall having any meaningful conversation around side effects except the mention of osteonecrosis of the jaw and the need for thorough dental check ups and good oral hygeine.
After my first dose of Prolia in August 2020 I became very depressed and my knee, in which I did have osteoarthritis became extremely painful quite suddenly, such that I had a total knee replacement in April 2021.
There have been having ongoing issues with musculoskeletal pain, I developed cataracts, high cholesterol and other disagreeable side effects including my hair falling out which may not be a medical emergency but it sure hits your self esteem. As I was never given any indication that these were side effects of Prolia I simply believed I was falling apart. To age 10 years in a period of 3.5 years is not normal, it is a result of Prolia (denosumab). After my 7th injection the musculoskeletal pain ramped up to an alarming level and I decided to discontinue Prolia.
I have over the past 4 months been educating myself about Prolia through peer reviewed papers, studies and articles. I am very unhappy about what I have learned.
I consulted an endocrinologist to take me through the long, expensive and unpleasant transition from Prolia to a bisphosphonate and will have my first infusion of zoledronic acid on May 5th. I am not looking forward to that but hope that my bone turnover will be controlled and will have bone turnover markers tested every 3 months to ensure I don't go into rebound. When it is all over in 12 or 24 months I hope to get my life back. We'll see.

DO NOT take this drug without being fully informed about the unique and dangerous REBOUND EFFECT that is unique to this drug. Doctors and even OP specialists are often inexcusably unaware of this even though the manufacturer warns about it, the research and studies report and warn about it, rebound requires expert treatment.

? I know better but I say nothing because they are too old to understand and I don’t want to worry them - I stopped taking Prolia nearly five years ago I still can’t walk without the walker and I live with the pain everyday - in list of side effects it says don’t stop taking Prolia otherwise you will fracture ? I haven’t luckily- but I’m too afraid to have an X-ray because I can’t lie straight because of pain - I have no thyroid and was diagnosed after first X-ray with osteopenia not osteoporosis? which is very different so I’m told by my support group - and I think that maybe that’s two reasons why doctor shouldn’t have given me the injection - he also never discussed any side effects just handed me a script I took it back and then he injected me with the drug- I also get rashes every now and again - I’ve never had a rash in my whole life -