I take about 1000 mg of Diphenhydramine HCI every night to sleep. What are the side effects?

Have you tried going to a Pychatrist? I take 30mg. of Restoril it's for Insomnia. I also take with it. 100mg. Benadryl, 50mg. Vistaril and 2mg. Ativan. I don't get the greatest sleep but it's enough. I've been on medication for years. Almost 22. I started out with 30mg. Dalmane which was the best, but it was discontinued. Also 2mg. Ativan. Over the years well your body gets used to it and I had to take more. My doctor added 50mg. Benadryl, but then that wasn't as good anymore. Now I'm taking 100mg. Benadryl, 2mg. Ativan, 50mg. Vistaril and 30mg. Restoril. It's not the best sleep but it's Ok.

Hi, I know the feeling all too well. I know many of us do actually. I’ve been there and it’s not fun. You think you’re tired and you can go to sleep, you lay down and then there you are just laying there. The one thing that I tried that is helped me the most and is legal in almost all states now is CBD. The thing is you have to look for 100% pure organic nothing else added to it and it will help you with so many other ailments. And of course Doctors are not going to tell you that. I have a friend that has cancer really bad and I got her some RSO, because of her pain she wasn’t able to sleep. I gave her that with the CBD and she was sleeping in five minutes. I say give it a try you have nothing to lose just don’t buy the cheap crap. It won’t work!

Hello. I think you may have typed in the wrong dosage you have been taking as I’ve taken 1000mgs before and it almost cost me my life. I think you mean 100 although that is also a bit high. If you’ve been taking this much per night I’d suggest talk to a professional for getting sleep aid. Also you must be taking doggy Benadryl bc i believe human Benadryl does not go that high. R. I. P.

In response to the comment in Feb 2019 - 1000mgs of Diph. getting you really sick. I am heading in that direction... I was taking 600-800mgs of trazodone, stopped working, I am also on Tylenol 4 - and I can't seem to find or shall I say the psych dr. has nothing to offer except Seroquel but I have adverse effects. - to my point I just started taking 500mgs of diphenhydramine at a time and if I don't sleep I take another 100-150 around 3am and again at 9am and end up sleeping during the day. This has got to stop because I know it is not good for my body or my mind - just stress of what damage it might cause is keeping me awake - how stupid is that. But if I don't take something I will never sleep. Please heed your own advice and stay off it - I myself with take all your words to heart and head. Thanks for your honesty!

It dries mucous membranes out and puts a lot of strain on your kidneys. You'll end up with kidney stones, liver problems, horrific constipation, your teeth will eventually fall out because the dry mouth and natural saliva is depleted. Stomach ulcers and esophageal erosion. High blood pressure, skin problems. Just about every system in your body will be compromised at some point. It really is slow, trauma to your body and you'll cut your life short. That's if one night you don't overdose. I know of someone who took so many she started to hallucinate, thought someone was in her house and was talking to them, she had seizures and would wake up on the floor face down, never knowing how long she had been there. You will kill yourself slowly and painfully. There are other routes to take for insomnia and if you don't care about yourself, figure out another, faster way to go. This will take years of high doses, but I guarantee you will suffer.

I know this is really late in responding. Please do not do this! If you are indeed taking this much, then will damage your liver! It will also cause damage to your kidneys, but because it is primarily metabolized in your liver it is hepatic cytotoxic. The maximum recommended dose is 400 mg daily. Even with that dosage, it can still cause liver damage overtime.

Please see your doctor for much safer alternatives (prescription will be required). I recommend these in the following order of greatest to smallest: remeron, trazodone, ambien. Good luck!

Taking that much Benadryl every night can't be healthy for you. I was advised to take up to 100 mg of Benadryl to sleep. Go see your PCP regarding your insomnia. Its a common problem and there are non narcotic sleep aids you could use. Atarax is like heavy duty Benadryl, another antihistamine. There are other options, but all require a script.
Please have a talk with your doc, tell him what you've been using so that he can prescribe an appropriate alternative.
Good luck and happy dreams.
Peace,
The Medicated for Insomnia Hippie
PS... I've been where you are. I hate not being able to sleep.

Hello, i take tylenol p.m. @ night(which has 500 mg of acetaminophen and 25 mg of diphenhydramine) for arthritis pain. I have been using this method for approximately the last 10yrs. with no bad side effects ,but with that much diphenhydramine ,use, i suggest seeing your family doctor.
As for side effects; there are quite a few; dizzines, drowsiness, dry mouth,throat,and nose, thickening of mucus in nose or throat.
You should seek medical attention right away if any of these severe side effects occur ! severe allergic reactions(difficulty breathing; hives,itching)
just to name a few.

I hope that this helps in your request for answers.

Sincerely ,
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