Brilinta Tablets Dosage

General Instructions

Advise patients who miss a dose of BRILINTA to take their next dose at its scheduled time.

For patients who are unable to swallow tablets whole, BRILINTA tablets can be crushed, mixed with water, and drunk.

The mixture can also be administered via a nasogastric tube (CH8 or greater) [see Clinical Pharmacology (12.3)].

Do not administer BRILINTA with another oral P2Y12 platelet inhibitor.

Avoid aspirin at doses higher than recommended [see Clinical Studies (14.1)].

Acute Coronary Syndrome or a History of Myocardial Infarction

​Initiate treatment with a 180 mg loading dose of BRILINTA. Administer the first 90 mg maintenance dose of

​BRILINTA, 6 to 12 hours after the loading dose. Administer 90 mg of BRILINTA twice daily during the first year after

​an ACS event. After one year, administer 60 mg of BRILINTA twice daily.

​Initiate BRILINTA with a daily maintenance dose of aspirin of 75 mg to 100 mg. However, in patients who have

​undergone percutaneous coronary intervention (PCI), consider single antiplatelet therapy with BRILINTA based on the

​evolving risk for thrombotic versus bleeding events [see Warnings and Precautions (5.1) and Clinical Studies (14)].

Coronary Artery Disease but No Prior Stroke or Myocardial Infarction

Administer 60 mg of BRILINTA twice daily.

Generally, use BRILINTA with a daily maintenance dose of aspirin of 75 mg to 100 mg [see Clinical Studies (14)].

Acute Ischemic Stroke or Transient Ischemic Attack (TIA)

​Initiate treatment with a 180 mg loading dose of BRILINTA and then continue with 90 mg twice daily for up to 30 days.

​Administer the first maintenance dose 6 to 12 hours after the loading dose.

Use BRILINTA with a loading dose of aspirin (300 mg to 325 mg) and a daily maintenance dose of aspirin of 75 mg to

100 mg [see Clinical Studies (14)].