Skip to main content


Generic name: trifarotene
Dosage form: Topical Cream
Drug class: Topical acne agents
Approval date: October 4, 2019
Company: Galderma
Treatment for: Acne Vulgaris

Medically reviewed by Judith Stewart, BPharm. Last updated on Sep 25, 2023.

Patient Information

Important Information

Aklief Cream is for use on the skin only. Do not use Aklief Cream in your mouth, eyes, or vagina.

What is Aklief Cream?

Aklief Cream is a prescription medicine used on the skin (topical) to treat acne vulgaris in people 9 years of age and older.

It is not known if Aklief Cream is safe and effective in children younger than 9 years old.

Before using Aklief Cream

Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you use any other medicine for acne.

How should I use Aklief Cream?

Applying Aklief Cream:

What should I avoid while using Aklief Cream?

Aklief side effects

Aklief Cream may cause serious side effects including:

The most common side effects of Aklief Cream include: itching and sunburn.

See What should I avoid while using Aklief Cream?

These are not all the possible side effects. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

You may also report side effects to GALDERMA LABORATORIES, L.P. at 1-866-735-4137.

How should I store Aklief Cream?

Keep Aklief Cream and all medicines out of the reach of children.

General information about the safe and effective use of Aklief Cream.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information Leaflet. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms you have. It may harm them. You can ask your pharmacist or healthcare provider for information that is written for health professionals.

What are the ingredients in Aklief Cream?

Active ingredient: trifarotene

Inactive ingredients: allantoin, copolymer of acrylamide and sodium acryloyldimethyltaurate, dispersion 40% in isohexadecane, cyclomethicone, 5% ethanol, medium-chain triglycerides, phenoxyethanol, propylene glycol, purified water.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.