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Relpax Side Effects

Generic Name: eletriptan

Note: This page contains side effects data for the generic drug eletriptan. It is possible that some of the dosage forms included below may not apply to the brand name Relpax.

Common side effects of Relpax include weakness. Other side effects include dizziness, drowsiness, chest pain, paresthesia, nausea, chest tightness, and chest pressure. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to eletriptan: oral tablet

As well as its needed effects, eletriptan (the active ingredient contained in Relpax) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking eletriptan, check with your doctor immediately:

Less common
  • Chest pain or tightness
  • difficulty with swallowing
  • tightness in the throat
  • Chest discomfort
  • dizziness
  • headache
  • nausea
  • nosebleeds
  • numbness or tingling in the face, arms or legs
  • pain or discomfort in the arms, jaw, back or neck
  • sweating
  • vision problems
  • vomiting
Incidence not known
  • Abdominal or stomach pain
  • agitation
  • bloody diarrhea
  • confusion
  • cough
  • diarrhea
  • difficulty in speaking
  • fainting
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fever
  • inability to move arms, legs, or facial muscles
  • overactive reflexes
  • pain in the arms legs, or lower back, especially pain in calves or heels upon exertion
  • pale, bluish-colored, or cold hands or feet
  • paleness or cold feeling in fingertips and toes
  • poor coordination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • restlessness
  • seizures
  • severe or sudden headache
  • shivering
  • skin rash, hives, or itching
  • slurred speech
  • sudden loss of coordination
  • sweating
  • talking or acting with excitement you cannot control
  • tingling or pain in the fingers or toes when exposed to cold
  • trembling or shaking
  • twitching
  • unusual tiredness or weakness
  • weak or absent pulses in the legs
  • weakness in the arm or leg on one side of the body, sudden and severe

Some eletriptan side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Lack or loss of strength
  • sleepiness or unusual drowsiness
Less common
  • Acid or sour stomach
  • belching
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • dry mouth
  • heartburn
  • indigestion
  • stomach soreness or discomfort
  • stomach upset

For Healthcare Professionals

Applies to eletriptan: oral tablet


Serious cardiac events are extremely rare and most have been reported in patients with risk factors predictive of coronary artery disease.[Ref]

Serious cardiovascular side effects following the use of 5-HT1 agonists have included coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia, and ventricular fibrillation. Some of these events have been fatal. Tightness/pain/pressure in the chest (up to 4%) have also been reported. Palpitation has been reported frequently. Hypertension, peripheral vascular disorder, and tachycardia have been reported infrequently. Angina pectoris, arrhythmia, atrial fibrillation, AV block, bradycardia, hypotension, syncope, thrombophlebitis, cerebrovascular disorder, vasospasm, and ventricular arrhythmia have been reported rarely.[Ref]


Cerebrovascular side effects including hemorrhage, subarachnoid hemorrhage, stroke, and other cerebrovascular events have been reported in patients treated with 5-HT1 agonists. Some of these events have resulted in fatalities.[Ref]


Gastrointestinal side effects including nausea (up to 8%), dry mouth (up to 4%), pain/discomfort/stomach pain/cramps/pressure (up to 2%), dyspepsia (up to 2%), and dysphagia (up to 2%) have been reported. Anorexia, constipation, diarrhea, eructation, esophagitis, flatulence, gastritis, gastrointestinal disorder, glossitis, increased salivation, and liver function test abnormalities have been reported infrequently. Gingivitis, hematemesis, increased appetite, rectal disorder, stomatitis, tongue disorder, tongue edema, and tooth disorder have been reported rarely. Vomiting has been reported during postmarketing use.


Nervous system

Nervous system side effects including dizziness (up to 7%), somnolence (up to 7%), and headache (up to 4%) have been reported. Hypertonia, hypesthesia, and vertigo have been reported frequently. Abnormal dreams, agitation, anxiety, apathy, ataxia, confusion, depersonalization, depression, emotional lability, euphoria, hyperesthesia, hyperkinesia, incoordination, insomnia, nervousness, speech disorder, stupor, abnormal thinking, and tremor have been reported infrequently. Abnormal gait, amnesia, aphasia, catatonic reaction, dementia, diplopia, dystonia, hallucinations, hemiplegia, hyperalgesia, hypokinesia, hysteria, manic reaction, neuropathy, neurosis, oculogyric crisis, paralysis, psychotic depression, sleep disorder, and twitching have been reported rarely. Postmarketing reports have included seizure.[Ref]


General side effects including asthenia (up to 10%), paresthesia (up to 4%), and a flushing/feeling of warmth (2%) have been reported. Back pain, chills, and pain have been reported frequently. Facial edema and malaise have been reported infrequently. Abdominal enlargement, abscess, accidental injury, fever, flu syndrome, halitosis, hernia, hypothermia, lab test abnormalities, moniliasis, rheumatoid arthritis, and shock have been reported rarely.[Ref]


Hypersensitivity side effects including allergic reaction have been reported rarely.[Ref]


Endocrine side effects including goiter, thyroid adenoma, and thyroiditis have been reported rarely.[Ref]


Hematologic side effects including anemia, cyanosis, leukopenia, lymphadenopathy, monocytosis, and purpura have been reported rarely.[Ref]


Metabolic side effects including increased creatine phosphokinase, edema, peripheral edema, and thirst have been reported infrequently. Increased alkaline phosphatase bilirubinemia, hyperglycemia, weight gain, and weight loss have been reported rarely.[Ref]


Musculoskeletal side effects including arthralgia, arthritis, arthrosis, bone pain, myalgia, and myasthenia have been reported infrequently. Bone neoplasm, joint disorder, myopathy, and tenosynovitis have been reported rarely.[Ref]


Respiratory side effects including pharyngitis have been reported frequently. Asthma, dyspnea, respiratory disorder, respiratory tract infection, rhinitis, voice alteration, and yawn have been reported infrequently. Bronchitis, choking sensation, increased cough, epistaxis, hiccup, hyperventilation, laryngitis, sinusitis, and increased sputum have been reported rarely.[Ref]


Dermatologic side effects including sweating have been reported frequently. Pruritus, rash, and skin disorder have been reported infrequently. Alopecia, dry skin, eczema, exfoliative dermatitis, maculopapular rash, psoriasis, skin discoloration, skin hypertrophy, and urticaria have been reported rarely.[Ref]


Ocular side effects including abnormal vision, conjunctivitis, eye pain, lacrimation disorder, and photophobia have been reported infrequently. Abnormality of accommodation, dry eyes, eye hemorrhage, and ptosis have been reported rarely.[Ref]


Other side effect affecting the senses including ear pain, taste perversion, and tinnitus have been reported infrequently. Ear disorder, otitis media, and parosmia have been reported rarely.[Ref]


Genitourinary side effects including impotence, polyuria, urinary frequency, and urinary tract disorder have been reported infrequently. Breast pain, kidney pain, leukorrhea, menorrhagia, menstrual disorder, and vaginitis have been reported rarely.[Ref]


1. "Product Information. Relpax (eletriptan)." Pfizer U.S. Pharmaceuticals, New York, NY.

It is possible that some side effects of Relpax may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.