Generic Name: verapamil (oral) (ver AP a mil)
Brand Names: Calan, Calan SR, Isoptin SR, Verelan, Verelan PM, Isoptin, Isoptin I.V., Covera-HS
What is verapamil?
Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels.
Verapamil is used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders.
Verapamil may also be used for purposes not listed in this medication guide.
You should not use verapamil if you have a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), severe heart failure, slow heartbeats that have caused you to faint, or certain heart rhythm disorders of the atrium (the upper chambers of the heart that allow blood to flow into the heart).
Before taking this medicine
You should not use verapamil if you are allergic to it, or if you have a serious heart condition such as:
"sick sinus syndrome" or "AV block" (unless you have a pacemaker);
severe heart failure;
slow heartbeats that have caused you to faint; or
certain heart rhythm disorders of the atrium (the upper chambers of the heart that allow blood to flow into the heart).
To make sure verapamil is safe for you, tell your doctor if you have:
congestive heart failure;
low blood pressure;
liver disease; or
a nerve-muscle disorder such as myasthenia gravis or muscular dystrophy.
FDA pregnancy category C. It is not known whether verapamil will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
See also: Pregnancy and breastfeeding warnings (in more detail)
Verapamil can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take verapamil?
Take verapamil exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Do not crush, chew, or break an extended-release verapamil tablet or capsule. Swallow it whole.
If you have trouble swallowing an extended-release capsule whole, ask your doctor or pharmacist if it is safe for you to open the capsule and sprinkle the medicine into a spoonful of applesauce to make swallowing easier. Swallow this mixture right away without chewing. Do not save the mixture for later use. Discard the empty capsule.
Your blood pressure will need to be checked often. Your kidney or liver function may also need to be checked.
If you need surgery, tell the surgeon ahead of time that you are using verapamil.
You should not stop using verapamil suddenly. Stopping suddenly may make your condition worse.
If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Verapamil may be only part of a complete program of treatment that also includes diet, exercise, and other medications. Follow your doctor's instructions very closely.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of verapamil can be fatal.
What should I avoid?
Verapamil may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of verapamil.
Grapefruit and grapefruit juice may interact with verapamil and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
Verapamil side effects
Get emergency medical help if you have any of these signs of an allergic reaction to verapamil: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
fast, slow, or irregular heartbeats;
shortness of breath (even with mild exertion), swelling, rapid weight gain;
a light-headed feeling, like you might pass out;
anxiety, sweating, pale skin, wheezing, gasping for breath, cough with foamy mucus, chest pain;
flu symptoms (fever, chills, body aches, vomiting, diarrhea); or
feeling like you might pass out.
Common verapamil side effects may include:
stuffy nose, sinus pain, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect verapamil?
Many drugs can interact with verapamil. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with verapamil, especially:
other blood pressure medicines;
St. John's wort;
an antibiotic--clarithromycin, erythromycin, telithromycin;
antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
cholesterol lowering medicines called "statins"--atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin;
heart medication--nicardipine, quinidine;
hepatitis C medications--boceprevir, telaprevir;
HIV/AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir;
seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or
tuberculosis medication--isoniazid, rifabutin, rifampin, rifapentine.
This list is not complete and many other drugs can interact with verapamil. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
More about verapamil
- Verapamil immediate-release
- Verapamil immediate-release tablets
- Verapamil long-acting tablets
- Verapamil sustained-release capsules controlled onset
- More (4) »
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about verapamil.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use verapamil only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2015 Cerner Multum, Inc. Version: 13.01. Revision Date: 2013-06-13, 10:21:08 AM.