Oxybutynin Side Effects

It is possible that some side effects of oxybutynin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to oxybutynin: oral syrup, oral tablet, oral tablet extended release

As well as its needed effects, oxybutynin may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking oxybutynin, check with your doctor immediately:

  • Eye pain
  • skin rash or hives

If any of the following symptoms of overdose occur while taking oxybutynin, get emergency help immediately:

Symptoms of overdose
  • Clumsiness or unsteadiness
  • confusion
  • convulsions
  • dizziness
  • drowsiness (severe)
  • fainting
  • fast, slow, or irregular heartbeat
  • fever
  • flushing or redness of the face
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • shortness of breath or troubled breathing
  • unusual excitement, nervousness, restlessness, or irritability

Some oxybutynin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Acid or sour stomach
  • belching
  • decreased sweating
  • diarrhea
  • difficulty having a bowel movement (stool)
  • drowsiness
  • dryness of the eyes, mouth, nose, or throat
  • heartburn
  • indigestion
  • runny nose
  • stomach discomfort, upset, or pain
Less common or rare
  • Blurred vision
  • decreased flow of breast milk
  • decreased sexual ability
  • difficulty in swallowing
  • feeling of warmth or heat
  • headache
  • increased sensitivity of the eyes to light
  • nausea or vomiting
  • trouble with sleeping
  • unusual tiredness or weakness
Incidence not known - Observed during clinical practice with oxybutynin; estimates of frequency cannot be determined
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • decreased interest in sexual intercourse
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss

For Healthcare Professionals

Applies to oxybutynin: oral syrup, oral tablet, oral tablet extended release, transdermal film extended release, transdermal gel

Nervous system

Very common (10% or more): Dizziness, somnolence
Common (1% to 10%): Headache, confusion, insomnia, nervousness, convulsions, dysgeusia
Frequency not reported: Heat stroke, paralysis, coma, CNS excitation


Reports of moderate to severe dry mouth was significantly lower in the group of people taking oxybutynin extended-release form in a study, at the same daily dose, comparing it to oxybutynin immediate-release. The reported incidence of dry mouth with the extended-release formulation is lower with the use of lower daily doses.

Dry mouth has been mentioned as the primary reason given by patients for discontinuation of therapy.

Very common (10% or more): Dry mouth, constipation, nausea
Common (1% to 10%): Dyspepsia, diarrhea, flatulence, vomiting, decreased GI motility, loose stools, aptyalism, eructation, tongue coated, gastroesophageal reflux, abdominal pain, taste perversion
Uncommon (0.1% to 1%): Dysphagia, frequent bowel movements
Frequency not reported: Taste perversion


Common (1% to 10%): Palpitations, peripheral edema, tachycardia, vasodilation, hypertension, chest pain
Uncommon (0.1% to 1%): Hot flush
Rare (less than 0.1%): Chest discomfort
Frequency not reported: Hypotension
Postmarketing reports: QT interval prolongation, arrhythmia, flushing


Very common (10% or more): Pruritus with transdermal system
Common (1% to 10%): Decreased sweating, dry skin, rash, pruritus
Frequency not reported: Application site vesicles, macules, burning, rash, and erythema with transdermal system.


Very common (10% or more): Impaired urination, urinary tract infections
Common (1% to 10%): Increased post void retention, urinary retention, impotence, urinary hesitancy, dysuria, pollakiuria
Frequency not reported: Dysuria, cystitis, aggravation of symptoms of prostatic hypertrophy


Postmarketing reports: Suppression of lactation


Uncommon (0.1% to 1%): Anorexia, fluid retention, increased blood glucose
Frequency not reported: Dehydration, aggravation of hyperthyroidism symptoms


Very common (10% or more): Blurred vision
Common (1% to 10%): Cycloplegia, dry eyes, mydriasis, keratoconjunctivitis sicca, eye irritation
Frequency not reported: Acute angle closure glaucoma, amblyopia, decreased lacrimation
Postmarketing reports: Glaucoma


Common (1% to 10%): Rhinitis, bronchitis, nasal dryness, oropharyngeal pain, cough, dry throat, sinus/nasal congestion, hoarseness, asthma, dry nasal and sinus mucous membranes
Uncommon (0.1% to 1%): Dysphonia
Frequency not reported: Upper respiratory tract infections, sinusitis, bronchitis, pharyngitis, respiratory failure


Common (1% to 10%): Asthenia, back pain, arthralgia, pain in extremity, flank pain
Frequency not reported: Arthritis


Common (1% to 10%): Depression, nervousness, insomnia, confusional state
Frequency not reported: Cognitive and mental status changes in elderly patients
Postmarketing reports: Hallucinations, psychotic disorder, agitation, memory impairment


Common (1% to 10%): Fatigue, fungal infection
Uncommon (0.1% to 1%): Thirst
Frequency not reported: Accidental injury, flu syndrome, flushing, fever
Postmarketing reports: Falls


Frequency not reported: Angioedema with airway obstruction, urticaria, and face edema and rare anaphylactic reactions

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