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Urinary antispasmodics

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Urinary antispasmodics are anticholinergic agents that inhibit involuntary detrusor contractions.

There are two types of nicotinic receptors: muscle type (mainly in skeletal neuromuscular junction) or neuronal type (in autonomic ganglia, sensory nerve terminals and other regions in the central nervous system). There are three types of muscarinic receptors M1, M2, M3. M1 receptors (neural) mainly located in the central nervous system, M2 receptors (cardiac) in atria and conducting tissue, and M3 receptors (glandular) in exocrine glands, smooth muscle and vascular endothelium.

Urinary antispasmodics can be nonselective anticholinergic agents, ones that can bind to all the receptors of the cholinergic system (nicotinic and muscarinic receptors) or they can selectively block M3 (muscarinic) receptors. Selective M3 receptor blockers cause less drowsiness compared to the nonselective anticholinergic drugs, but they can cause more constipation, dry mouth and blurred vision.

Urinary antispasmodics are used to treat symptoms of urge incontinence and overactive bladder.

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