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Mobic Side Effects

Generic Name: meloxicam

Note: This page contains information about the side effects of meloxicam. Some of the dosage forms included on this document may not apply to the brand name Mobic.

More frequent side effects include abdominal pain, edema, and anemia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to meloxicam: oral suspension, oral tablet

In addition to its needed effects, some unwanted effects may be caused by meloxicam (the active ingredient contained in Mobic). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking meloxicam:

Less common
  • Arm, back, or jaw pain
  • bleeding gums
  • bloating
  • blood in the urine
  • blurred vision
  • burning upper abdominal or stomach pain
  • canker sores
  • chest tightness or heaviness
  • chills
  • cloudy urine
  • cough
  • cramping
  • dark urine
  • decreased frequency or amount of urine
  • difficult or labored breathing
  • dilated neck veins
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • general tiredness and weakness
  • headache
  • hives or welts
  • increased blood pressure
  • increased sensitivity of the skin to sunlight
  • increased thirst
  • irregular breathing
  • itching, redness, or other discoloration of the skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of appetite
  • lower side or back pain
  • noisy breathing
  • pain or discomfort in the arms, jaw, back, or neck
  • painful or difficult urination
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pinpoint red or purple spots on the skin
  • pounding in the ears
  • redness, soreness, or itching skin
  • seizures
  • severe and continuing nausea
  • severe sunburn
  • shakiness in the legs, arms, hands, or feet
  • skin blisters
  • sore throat
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
  • sores, welting, or blisters
  • stomach bloating, burning, cramping, tenderness, or pain
  • sweating
  • swelling or puffiness of the face
  • swollen glands
  • trembling or shaking of the hands or feet
  • trouble with breathing
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • watery or bloody diarrhea
  • weight gain or loss
  • yellow eyes or skin
  • Area rash
  • blistering, peeling, or loosening of the skin
  • bloody or black, tarry stools
  • clay-colored stools
  • cold, clammy skin
  • continuing vomiting
  • cough or hoarseness
  • cracks in the skin
  • difficulty with swallowing
  • fast, weak pulse
  • fever with or without chills
  • greatly decreased frequency of urination or amount of urine
  • joint or muscle pain
  • lightheadedness
  • loss of heat from the body
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • scaly skin
  • severe stomach pain
  • shortness of breath
  • tightness in the chest
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • wheezing
Incidence not known
  • Difficulty with speaking
  • double vision
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • pains in the chest, groin or legs, especially the calves
  • severe headaches of sudden onset
  • slow speech
  • sudden loss of coordination
  • sudden onset of shortness of breath for no apparent reason
  • sudden onset of slurred speech
  • sudden vision changes

If any of the following symptoms of overdose occur while taking meloxicam, get emergency help immediately:

Symptoms of overdose
  • Blue lips, fingernails, or skin
  • convulsions (seizures)
  • pain in the chest, upper stomach, or throat
  • severe stomach pain
  • skin rash
  • slow or fast heartbeat
  • swelling around the eyes, face, lips, or tongue
  • weight gain (rapid)

Some of the side effects that can occur with meloxicam may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Diarrhea
  • gas
  • heartburn
  • indigestion
Less common or rare
  • Abdominal or stomach pain
  • abnormal dreaming
  • anxiety
  • appetite increased
  • bad, unusual, or unpleasant after taste
  • belching
  • bloated or full feeling
  • burning feeling in the chest or stomach
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • burning, dry, or itching eyes
  • change in taste
  • changes in vision
  • confusion
  • constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased urination
  • discharge
  • discouragement
  • dry mouth
  • excess air or gas in the stomach
  • excessive tearing
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • general feeling of discomfort or illness
  • hair loss
  • hearing loss
  • hot flushes
  • irritability
  • loss of interest or pleasure
  • nausea or vomiting
  • nervousness
  • pain or burning in the throat
  • rapid breathing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • sensation of spinning
  • sleepiness
  • stomach upset
  • sunken eyes
  • tenderness in the stomach area
  • thinning of the hair
  • thirst
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • wrinkled skin

For Healthcare Professionals

Applies to meloxicam: oral capsule, oral suspension, oral tablet


Flatulence and dyspepsia were either as common or more frequent among placebo patients. Gastrointestinal side effects have been the most frequently reported adverse events from over 10 placebo-controlled trials with patients with osteoarthritis.[Ref]

Gastrointestinal (GI) side effects have included abdominal pain in 2% to 5%, constipation in 1% to 3%, diarrhea in 2% to 6%, dyspepsia in 4% to 10%, flatulence in 1% to 3%, nausea in 2% to 7%, and vomiting in up to 3% of patients. Other GI side effects reported in less than 2% of patients have included colitis, dry mouth, duodenal ulcer, eructation, esophagitis, gastric ulcer, gastritis, gastroesophageal reflux, gastrointestinal hemorrhage, hematemesis, hemorrhagic perforation, melena, pancreatitis, perforated duodenal ulcer, perforated gastric ulcer, and ulcerative stomatitis.[Ref]

Nervous system

Nervous system side effects have included headache (2% to 8%), dizziness (1% to 3%), and insomnia (0% to 4%). Nervous system side effects reported in less than 2% of treated patients have included convulsions, paresthesia, tremor, vertigo, abnormal vision, conjunctivitis, taste perversion, and tinnitus.[Ref]


Cardiovascular side effects have included edema which has been reported by approximately 1% to 5% of patients involved in studies. Other cardiovascular side effects have included angina pectoris, cardiac failure, hypertension, hypotension, myocardial infarction, vasculitis, arrhythmia, dehydration or decreased intravascular volume, palpitations, and tachycardia.[Ref]


Respiratory system side effects have included cough in up to 2% and pharyngitis or upper respiratory infection in up to 8% of patients. The incidence of infection was similar in some studies among placebo patients or patients taking another NSAID. A causal relationship was not established. Respiratory system side effects in less than 2% of patients have included asthma, bronchospasm, and dyspnea.[Ref]


Dermatologic side effects have included rash (1% to 3%) and pruritus in up to 2% of patients. Dermatologic side effects observed in less than 2% of patients have included alopecia, angioedema, bullous eruption, erythema multiforme, photosensitivity reaction, pruritus, Stevens-Johnson syndrome, increased sweating, toxic epidermal necrolysis, and urticaria.[Ref]


Hematologic side effects have included anemia (reported in more than 2% of patients, but only in some studies.) The incidence has ranged from 0.1% to 4%. Stool sampling for blood loss was not reported in these studies. Other hematologic side effects have included agranulocytosis, leukopenia, purpura, and thrombocytopenia.[Ref]


Musculoskeletal side effects have included arthralgias in up to 5% and back pain in up to 3% of patients. (The underlying condition of test patients was osteoarthritis.)[Ref]


Genitourinary side effects have included new urinary tract infections in up to 7% of patients (it has been the only genitourinary complaint reported in at least 2% of patients.) Hematuria has been associated with the use of meloxicam (the active ingredient contained in Mobic) in less than 2% of patients. Acute urinary retention has been reported in less than 0.1% of patients in postmarketing experience.[Ref]


Hypersensitivity reactions have included anaphylactic shock, facial edema, fever, hot flashes, syncope, fatigue, and malaise.[Ref]


Hepatic side effects have been rarely reported (2% or less). These have included, increased serum enzymes (ALT, AST, and GGT), bilirubinemia, hepatitis, jaundice, and liver failure.[Ref]


Psychiatric side effects have included abnormal dreaming, anxiety, confusion, depression, nervousness, and somnolence.[Ref]


Renal side effects have included urinary frequency, albuminuria, increased BUN, increased serum creatinine, hematuria, interstitial nephritis, and renal failure. New or worsened renal insufficiency has been rarely associated with the use of meloxicam (the active ingredient contained in Mobic) (less than 2% of treated patients).[Ref]


Other side effects including household accident have been reported in greater than or equal to 2% of patients.[Ref]


1. "Product Information. Mobic (meloxicam)" Boehringer-Ingelheim, Ridgefield, CT.

2. Singh G, Lanes S, Triadafilopoulos G "Risk of serious upper gastrointestinal and cardiovascular thromboembolic complications with meloxicam." Am J Med 117 (2004): 100-6

3. Martin RM, Biswas P, Mann RD "The incidence of adverse events and risk factors for upper gastrointestinal disorders associated with meloxicam use amongst 19,087 patients in general practice in England: cohort study." Br J Clin Pharmacol 50 (1999): 35-42

4. Rinder HM, Tracey JB, Souhrada M, Wang C, Gagnier RP, Wood CC "Effects of meloxicam on platelet function in healthy adults: a randomized, double-blind, placebo-controlled trial." J Clin Pharmacol 42 (2002): 881-6

Not all side effects for Mobic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.