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Meloxicam Pregnancy and Breastfeeding Warnings

Meloxicam is also known as: Mobic

Meloxicam Pregnancy Warnings

Meloxicam has been assigned to pregnancy category C prior to 30 weeks gestation and category D starting at 30 weeks gestation by the FDA. Animal data have revealed evidence of heart defects and embryolethality after extraordinary doses (64.5 times and 5.4 times the maximum recommended human dose (MRHD), based on body surface area conversions). Animal data have failed to reveal evidence of teratogenicity after oral doses equivalent to 2.2 times the MRHD; however there was an increased rate of stillbirths after oral doses that approximated the MRHD. Animal data have also revealed a reduction in birth index, live births, and neonatal survival at doses less than the MRHD. Meloxicam crosses the placental barrier. Prior to 30 weeks gestation, meloxicam should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Starting at 30 weeks gestation, meloxicam and other NSAIDs should be avoided in pregnant women as premature closure of the ductus arteriosus in the fetus may occur. If meloxicam is used during this time period in pregnancy, the patient should be informed of the potential hazard to the fetus.

Meloxicam Breastfeeding Warnings

There are no data on the excretion of meloxicam into human milk; however, meloxicam was excreted in the milk of lactating rats at concentrations higher than those in plasma. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the nursing mother.

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