Medication Guide App

Lincocin Side Effects

Generic Name: lincomycin

Note: This page contains side effects data for the generic drug lincomycin. It is possible that some of the dosage forms included below may not apply to the brand name Lincocin.

It is possible that some side effects of Lincocin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to lincomycin: capsule, solution

Along with its needed effects, lincomycin (the active ingredient contained in Lincocin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lincomycin:

More common
  • Abdominal or stomach cramps and pain (severe)
  • abdominal tenderness
  • diarrhea (watery and severe), which may also be bloody
  • fever
Less common
  • Skin rash, redness, and itching
  • sore throat and fever
  • unusual bleeding and bruising

Note: Some of the above side effects may also occur up to several weeks after you Stop taking lincomycin.

Some side effects of lincomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea (mild)
  • nausea and vomiting
  • stomach pain
Less common
  • Itching of rectal or genital (sex organ) areas

For Healthcare Professionals

Applies to lincomycin: compounding powder, injectable solution, oral capsule


Gastrointestinal side effects have included glossitis, stomatitis, nausea, vomiting, diarrhea (up to 49%), colitis, pruritus ani, pseudomembranous colitis (up to 14%), and metallic taste in mouth (4%).


A 19-year-old male patient, who had received 2 previous intramuscular injections of lincomycin (the active ingredient contained in Lincocin) at the age of 17 years and 1 intramuscular injection 2 weeks prior, reported that a few minutes after his fourth intramuscular injection of lincomycin he noticed a tingling sensation around his face and mouth. The patient's symptoms progressed to bright red to blue-violet skin discoloration, injection of the bulbar conjunctivae, and swelling of his face, neck, and ears. The patient recovered without incident after receiving adrenaline and betamethasone intramuscularly followed by oral prednisone with an antihistamine.

Hypersensitivity reactions have included angioneurotic edema, serum sickness, and anaphylaxis, with rare instances of erythema multiforme, some resembling Stevens-Johnson syndrome. At least one case of face, ears, and neck swelling and bulbar conjunctival injection have been reported.


Hematologic side effects have included neutropenia, leukopenia, agranulocytosis, thrombocytopenia, and thrombocytopenic purpura. There have been rare reports of aplastic anemia and pancytopenia; however, causality could not be determined.


Dermatologic side effects have included skin rashes, urticaria, and rarely, exfoliative and vesiculobullous dermatitis.


Hepatic side effects have included jaundice and abnormalities in liver function tests; however, causality could not be determined.


Renal side effects have included rare instances of azotemia, oliguria, and proteinuria.


Cardiovascular side effects have included rare cases of cardiopulmonary arrest and hypotension after lincomycin (the active ingredient contained in Lincocin) was administered intravenously too rapidly. In these cases, the affected patients subsequently tolerated slow infusions of lincomycin. A study that looked at multiple large dose administration of lincomycin found that when the doses were appropriately diluted and administered more slowly, cardiovascular changes did not occur.

Nervous system

Nervous system side effects have included neuromuscular blockade.


Genitourinary side effects have included vaginitis.


Local side effects have included infrequent reports of pain following intramuscular administration.


Other side effects have included tinnitus and vertigo.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.