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Eletriptan Side Effects

In Summary

Commonly reported side effects of eletriptan include: weakness. Other side effects include: dizziness, drowsiness, chest pain, paresthesia, nausea, chest tightness, and chest pressure. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to eletriptan: oral tablet

In addition to its needed effects, some unwanted effects may be caused by eletriptan. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking eletriptan:

Less common:
  • Chest pain or tightness
  • difficulty with swallowing
  • tightness in the throat
  • Chest discomfort
  • dizziness
  • headache
  • nausea
  • nosebleeds
  • numbness or tingling in the face, arms or legs
  • pain or discomfort in the arms, jaw, back or neck
  • sweating
  • vision problems
  • vomiting
Incidence not known:
  • Abdominal or stomach pain
  • agitation
  • bloody diarrhea
  • confusion
  • cough
  • diarrhea
  • difficulty in speaking
  • fainting
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fever
  • inability to move arms, legs, or facial muscles
  • overactive reflexes
  • pain in the arms legs, or lower back, especially pain in calves or heels upon exertion
  • pale, bluish-colored, or cold hands or feet
  • paleness or cold feeling in fingertips and toes
  • poor coordination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • restlessness
  • seizures
  • severe or sudden headache
  • shivering
  • skin rash, hives, or itching
  • slurred speech
  • sudden loss of coordination
  • sweating
  • talking or acting with excitement you cannot control
  • tingling or pain in the fingers or toes when exposed to cold
  • trembling or shaking
  • twitching
  • unusual tiredness or weakness
  • weak or absent pulses in the legs
  • weakness in the arm or leg on one side of the body, sudden and severe

Severity: Minor

Some of the side effects that can occur with eletriptan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Lack or loss of strength
  • sleepiness or unusual drowsiness
Less common:
  • Acid or sour stomach
  • belching
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • dry mouth
  • heartburn
  • indigestion
  • stomach soreness or discomfort
  • stomach upset

For Healthcare Professionals

Applies to eletriptan: oral tablet


Serious cardiac events are extremely rare and most have been reported in patients with risk factors predictive of coronary artery disease.[Ref]

Serious cardiovascular side effects following the use of 5-HT1 agonists have included coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia, and ventricular fibrillation. Some of these events have been fatal. Tightness/pain/pressure in the chest (up to 4%) have also been reported. Palpitation has been reported frequently. Hypertension, peripheral vascular disorder, and tachycardia have been reported infrequently. Angina pectoris, arrhythmia, atrial fibrillation, AV block, bradycardia, hypotension, syncope, thrombophlebitis, cerebrovascular disorder, vasospasm, and ventricular arrhythmia have been reported rarely.[Ref]


Cerebrovascular side effects including hemorrhage, subarachnoid hemorrhage, stroke, and other cerebrovascular events have been reported in patients treated with 5-HT1 agonists. Some of these events have resulted in fatalities.[Ref]


Gastrointestinal side effects including nausea (up to 8%), dry mouth (up to 4%), pain/discomfort/stomach pain/cramps/pressure (up to 2%), dyspepsia (up to 2%), and dysphagia (up to 2%) have been reported. Anorexia, constipation, diarrhea, eructation, esophagitis, flatulence, gastritis, gastrointestinal disorder, glossitis, increased salivation, and liver function test abnormalities have been reported infrequently. Gingivitis, hematemesis, increased appetite, rectal disorder, stomatitis, tongue disorder, tongue edema, and tooth disorder have been reported rarely. Vomiting has been reported during postmarketing use.


Nervous system

Nervous system side effects including dizziness (up to 7%), somnolence (up to 7%), and headache (up to 4%) have been reported. Hypertonia, hypesthesia, and vertigo have been reported frequently. Abnormal dreams, agitation, anxiety, apathy, ataxia, confusion, depersonalization, depression, emotional lability, euphoria, hyperesthesia, hyperkinesia, incoordination, insomnia, nervousness, speech disorder, stupor, abnormal thinking, and tremor have been reported infrequently. Abnormal gait, amnesia, aphasia, catatonic reaction, dementia, diplopia, dystonia, hallucinations, hemiplegia, hyperalgesia, hypokinesia, hysteria, manic reaction, neuropathy, neurosis, oculogyric crisis, paralysis, psychotic depression, sleep disorder, and twitching have been reported rarely. Postmarketing reports have included seizure.[Ref]


General side effects including asthenia (up to 10%), paresthesia (up to 4%), and a flushing/feeling of warmth (2%) have been reported. Back pain, chills, and pain have been reported frequently. Facial edema and malaise have been reported infrequently. Abdominal enlargement, abscess, accidental injury, fever, flu syndrome, halitosis, hernia, hypothermia, lab test abnormalities, moniliasis, rheumatoid arthritis, and shock have been reported rarely.[Ref]


Hypersensitivity side effects including allergic reaction have been reported rarely.[Ref]


Endocrine side effects including goiter, thyroid adenoma, and thyroiditis have been reported rarely.[Ref]


Hematologic side effects including anemia, cyanosis, leukopenia, lymphadenopathy, monocytosis, and purpura have been reported rarely.[Ref]


Metabolic side effects including increased creatine phosphokinase, edema, peripheral edema, and thirst have been reported infrequently. Increased alkaline phosphatase bilirubinemia, hyperglycemia, weight gain, and weight loss have been reported rarely.[Ref]


Musculoskeletal side effects including arthralgia, arthritis, arthrosis, bone pain, myalgia, and myasthenia have been reported infrequently. Bone neoplasm, joint disorder, myopathy, and tenosynovitis have been reported rarely.[Ref]


Respiratory side effects including pharyngitis have been reported frequently. Asthma, dyspnea, respiratory disorder, respiratory tract infection, rhinitis, voice alteration, and yawn have been reported infrequently. Bronchitis, choking sensation, increased cough, epistaxis, hiccup, hyperventilation, laryngitis, sinusitis, and increased sputum have been reported rarely.[Ref]


Dermatologic side effects including sweating have been reported frequently. Pruritus, rash, and skin disorder have been reported infrequently. Alopecia, dry skin, eczema, exfoliative dermatitis, maculopapular rash, psoriasis, skin discoloration, skin hypertrophy, and urticaria have been reported rarely.[Ref]


Ocular side effects including abnormal vision, conjunctivitis, eye pain, lacrimation disorder, and photophobia have been reported infrequently. Abnormality of accommodation, dry eyes, eye hemorrhage, and ptosis have been reported rarely.[Ref]


Other side effect affecting the senses including ear pain, taste perversion, and tinnitus have been reported infrequently. Ear disorder, otitis media, and parosmia have been reported rarely.[Ref]


Genitourinary side effects including impotence, polyuria, urinary frequency, and urinary tract disorder have been reported infrequently. Breast pain, kidney pain, leukorrhea, menorrhagia, menstrual disorder, and vaginitis have been reported rarely.[Ref]


1. "Product Information. Relpax (eletriptan)." Pfizer U.S. Pharmaceuticals, New York, NY.

Not all side effects for eletriptan may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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