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Dramamine Side Effects

Generic Name: dimenhydrinate

Note: This page contains information about the side effects of dimenhydrinate. Some of the dosage forms included on this document may not apply to the brand name Dramamine.

For the Consumer

Applies to dimenhydrinate: oral solution, oral tablets, parenteral injection

Side effects include:

Drowsiness, headache, blurred vision, tinnitus, dryness of the mouth and respiratory passages, incoordination, palpitation, dizziness, hypotension.

Paradoxical CNS stimulation in pediatric patients and occasionally in adults.

With IM injection: Pain at the injection site.

Because dimenhydrinate (the active ingredient contained in Dramamine) contains diphenhydramine, the possibility of other diphenhydramine-related adverse effects should also be considered.

For Healthcare Professionals

Applies to dimenhydrinate: compounding powder, injectable solution, oral liquid, oral tablet, oral tablet chewable

Nervous system

Nervous system side effects have commonly included drowsiness and sedation. Depression, impaired motor skills, CNS stimulation, nervousness, dizziness, excitation, and restlessness have been reported. CNS stimulation may paradoxically occur in some patients. Headache and tinnitus have been reported rarely. Convulsions and coma have also been reported.[Ref]


Genitourinary side effects have included urinary retention and dysuria as a result of the anticholinergic effects of dimenhydrinate (the active ingredient contained in Dramamine) [Ref]


Hypersensitivity side effects have been reported in patients receiving dimenhydrinate (the active ingredient contained in Dramamine) products containing tartrazine dye. These have included bronchial asthma and have occurred more likely in patients sensitive to aspirin.[Ref]


Gastrointestinal side effects reported as mild have included dry mouth, dry nose, dry throat, constipation, and diarrhea. Anorexia and epigastric distress have been reported.[Ref]


Respiratory side effects have included dryness of the respiratory passages, thickening of bronchial secretions, and respiratory depression.[Ref]


Cardiovascular side effects have included hypotension, palpitations, and tachycardia.[Ref]


Ocular side effects have included blurred vision, diplopia, and dry eyes due to anticholinergic effects.[Ref]


Other side effects have included lassitude.


1. "Product Information. Dramamine (dimenhydrinate)" Pharmacia and Upjohn, Kalamazoo, MI.

Not all side effects for Dramamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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