Cleocin Side Effects
Generic Name: clindamycin
Note: This page contains information about the side effects of clindamycin. Some of the dosage forms included on this document may not apply to the brand name Cleocin.
Not all side effects for Cleocin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to clindamycin: capsule, powder for solution, solution
In addition to its needed effects, some unwanted effects may be caused by clindamycin (the active ingredient contained in Cleocin). In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking clindamycin:More common
(the above side effects may also occur up to several weeks after you Stop taking clindamycin)
- Abdominal or stomach cramps and pain (severe)
- abdominal tenderness
- diarrhea (watery and severe), which may also be bloody
- Sore throat and fever
- skin rash, redness, and itching
- unusual bleeding or bruising
Some of the side effects that can occur with clindamycin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common
- Diarrhea (mild)
- nausea and vomiting
- stomach pain
- Itching of rectal, or genital (sex organ) areas
For Healthcare Professionals
Applies to clindamycin: compounding powder, injectable solution, intravenous solution, oral capsule, oral powder for reconstitution
The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment. It appears as a pale plaque on direct visualization of the mucosa by endoscopy and is sensitive to oral vancomycin or metronidazole. Pseudomembranous colitis may be associated with toxic megacolon, which can be life-threatening.
Frequency not reported: Nausea, vomiting, abdominal pain, esophagitis, diarrhea, Clostridium difficile associated diarrhea, pseudomembranous colitis, dry mouth, hairy tongue, upset stomach, gastrointestinal bleeding, mouth irritation
Rare (less than 0.1%): Erythema multiforme, anaphylactoid reactions, leukocytoclastic angiitis, toxic epidermal necrolysis, Stevens-Johnson syndrome
Frequency not reported: Vesiculobullous rashes, urticaria, edema, generalized mild to moderate morbilliform-like (maculopapular) skin rashes, drug rash with eosinophilia and systemic symptoms (DRESS syndrome)
Some cases of erythema multiforme resembled Stevens-Johnson syndrome.
Rare cases of leukocytoclastic angiitis, toxic epidermal necrolysis, erythema multiforme, and Stevens-Johnson syndrome associated with clindamycin hypersensitivity have been reported.
Rash was particularly common in AIDS patients.
A 47-year-old female patient with multiple comorbidities was diagnosed with Sweet's Syndrome. The patient's symptoms developed 2 days after initiating oral clindamycin (the active ingredient contained in Cleocin) therapy for a tooth infection. The patient's symptoms persisted despite tooth extraction and continuance of antibiotic treatment with intravenous, then oral, clindamycin. Following discontinuation of clindamycin, the patient's symptoms resolved over several days. Drug-induced Sweet's syndrome was determined based on the temporal relationship of the patient's symptoms, the beginning and end of clindamycin therapy, and the exclusion of other etiologies.
Three days after starting oral clindamycin for the persistence of symptoms following a root canal, a 34-year-old male patient reported "pimples" on his scalp which changed to pustules 24 hours later. The lesions progressed and the patient's antibiotic therapy was discontinued. Two days later, the rash improved considerably. The patient met the diagnostic criteria for drug-induced Sweet's syndrome and clindamycin was the most likely cause due to the timeline of antibiotic therapy and the patient's improvement following its discontinuation.
Rare (less than 0.1%): Exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, drug-induced Sweet's syndrome (at least 2 cases)
Frequency not reported: Pruritus, maculopapular rash (generalized pruritic), vesiculobullous rash, urticaria, acute generalized exanthematous pustulosis
Rare (less than 0.1%): High degree heart block, hypotension, cardiopulmonary arrest
Rare cases of high degree heart block, hypotension, and cardiopulmonary arrest have been reported after clindamycin was administered intravenously over several minutes. In these cases, the affected patients subsequently tolerated slow infusions of clindamycin.
Frequency not reported: Transient neutropenia (leukopenia), transient eosinophilia, agranulocytosis, thrombocytopenia, granulocytopenia
Neutropenia (ANC 945 cells/mm3) occurred in a 68-year-old male 6 days after receiving a single 600 mg oral dose of clindamycin. The neutrophil count normalized after 2 weeks.
Frequency not reported: Jaundice, abnormalities in liver function tests, cholestatic liver disease with ductopenia
Rare (less than 0.1%): Renal dysfunction (as shown by azotemia, oliguria, proteinuria)
Frequency not reported: Taste perversion/disorders (including bitter taste, taste loss, bad taste, taste alteration), parosmia
Frequency not reported: Vaginitis
Rare (less than 0.1%): Polyarthritis
Pain, induration, and sterile abscess have been reported after intramuscular administration and thrombophlebitis after intravenous infusion.
Frequency not reported: Pain, induration, sterile abscess, thrombophlebitis
More about Cleocin (clindamycin)
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