Cinoxacin Side Effects

Not all side effects for cinoxacin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cinoxacin: oral capsule

In addition to its needed effects, some unwanted effects may be caused by cinoxacin. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking cinoxacin, check with your doctor or nurse as soon as possible:

Less common
  • Skin rash, itching, redness, or swelling
  • black, tarry stools
  • bleeding gums
  • blood in urine or stools
  • Dizziness
  • headache
  • increased sensitivity of skin to sunlight
  • pinpoint red spots on skin
  • unusual bleeding or bruising
Incidence unknown
  • Bone pain
  • lower back or side pain
  • pain, inflammation, or swelling in calves, shoulders, or hands
  • painful, swollen joints
  • seizures

Some of the side effects that can occur with cinoxacin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Diarrhea
  • loss of appetite
  • nausea
  • stomach cramps
  • vomiting

For Healthcare Professionals

Applies to cinoxacin: oral capsule


Cinoxacin is generally well tolerated. Adverse effects occur in approximately 5% of treated patients.


Cinoxacin most commonly affects the gastrointestinal system, causing nausea, vomiting, and diarrhea in approximately 3% of treated patients.

Nervous system

Nervous system toxicity occurs in approximately 2% of patients treated with cinoxacin, and may include headache, dizziness, nervousness, and insomnia. Rarely, blurred vision has been reported. Other adverse effects rarely include paresthesias, somnolence, photophobia, and tinnitus.


Hypersensitivity reactions have been reported following cinoxacin administration in approximately 3% of patients. Hypersensitivity reactions most commonly involve rash, urticaria, pruritus, and edema. Anaphylaxis has been reported in a few patients who were previously sensitized to cinoxacin. A case of Henoch-Schonlein purpura has also been reported.


Hepatic effects of cinoxacin have rarely included transient elevations of liver function tests.

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