Cinoxacin Side Effects

Some side effects of cinoxacin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to cinoxacin: oral capsule

Along with its needed effects, cinoxacin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking cinoxacin:

Less common
  • Skin rash, itching, redness, or swelling
  • black, tarry stools
  • bleeding gums
  • blood in urine or stools
  • Dizziness
  • headache
  • increased sensitivity of skin to sunlight
  • pinpoint red spots on skin
  • unusual bleeding or bruising
Incidence unknown
  • Bone pain
  • lower back or side pain
  • pain, inflammation, or swelling in calves, shoulders, or hands
  • painful, swollen joints
  • seizures

Some side effects of cinoxacin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Diarrhea
  • loss of appetite
  • nausea
  • stomach cramps
  • vomiting

For Healthcare Professionals

Applies to cinoxacin: oral capsule


Cinoxacin is generally well tolerated. Adverse effects occur in approximately 5% of treated patients.


Cinoxacin most commonly affects the gastrointestinal system, causing nausea, vomiting, and diarrhea in approximately 3% of treated patients.

Nervous system

Nervous system toxicity occurs in approximately 2% of patients treated with cinoxacin, and may include headache, dizziness, nervousness, and insomnia. Rarely, blurred vision has been reported. Other adverse effects rarely include paresthesias, somnolence, photophobia, and tinnitus.


Hypersensitivity reactions have been reported following cinoxacin administration in approximately 3% of patients. Hypersensitivity reactions most commonly involve rash, urticaria, pruritus, and edema. Anaphylaxis has been reported in a few patients who were previously sensitized to cinoxacin. A case of Henoch-Schonlein purpura has also been reported.


Hepatic effects of cinoxacin have rarely included transient elevations of liver function tests.

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