Astepro Side Effects
Generic name: azelastine nasal
Note: This document contains side effect information about azelastine nasal. Some of the dosage forms listed on this page may not apply to the brand name Astepro.
Some side effects of Astepro may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to azelastine nasal: nasal spray
Along with its needed effects, azelastine nasal (the active ingredient contained in Astepro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking azelastine nasal:Rare
- Blood in the urine
- eye pain, eye redness, blurred vision or other change in vision
- rapid heartbeat
- shortness of breath, tightness in the chest, troubled breathing, or wheezing
- skin rash, hives, or itching
- sores in the mouth or on the lips
Some side effects of azelastine nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Bitter taste in the mouth
- drowsiness or sleepiness
- Bloody mucus or unexplained nosebleeds
- burning inside the nose
- dryness of the mouth
- muscle aches or pain
- sore throat
- sudden outbursts of sneezing
- unusual tiredness or weakness
- weight gain
For Healthcare Professionals
Applies to azelastine nasal: nasal spray
General side effects have included allergic reactions, back pain, herpes simplex, viral infection, malaise, pain in extremities, abdominal pain, and pyrexia. Azelastine nasal (the active ingredient contained in Astepro) spray has been generally well tolerated with the number of patients in clinical trials withdrawn due to adverse effects similar to placebo.
The bitter or altered taste is thought to be primarily related to the direct effects of azelastine reaching the mouth versus a systemic effect.
Gastrointestinal side effects have included constipation, gastroenteritis, glossitis, ulcerative stomatitis, vomiting, increased SGPT levels, aphthous stomatitis, diarrhea, and toothache. A bitter taste occurred in 19.7% of patients. Nausea and dry mouth occurred in 2.8% of patients on azelastine.
Nervous system side effects have included headache (14.8%) and somnolence (11.5%). Dizziness has also occurred infrequently. Hyperkinesia and hypokinesia have also been reported.
Local side effects have included nasal burning (4.1%), paroxysmal sneezing (3.1%), and epistaxis (2.0%).
Respiratory side effects which occurred in clinical trials with a frequency greater than placebo included pharyngitis (3.5%) and rhinitis (2.3%). Bronchospasm, coughing, throat burning, laryngitis, bronchitis, dry throat, nocturnal dyspnea, nasopharyngitis, nasal congestion, pharyngolaryngeal pain, sinusitis, nasal dryness, paranasal sinus hypersecretion, and post nasal drip have also been reported. Postmarketing reports have included nasal sores.
Endocrine side effects have included reports of weight increase in 2% of patients treated with azelastine.
Cardiovascular side effects have included infrequent reports of flushing, hypertension and tachycardia. Azelastine has not been shown to have significant effects on the QTc interval. Postmarketing reports have included atrial fibrillation and palpitations.
Other side effects included the loss of the sense of smell in one patient receiving azelastine nasal (the active ingredient contained in Astepro) spray. The effects lasted three days and resolved during the course of therapy.
Dermatologic side effects have included contact dermatitis, eczema, hair and follicle infection, furunculosis, and skin laceration.
Metabolic side effects have included increased appetite.
Musculoskeletal side effects have included myalgia, temporomandibular dislocation and rheumatoid arthritis.
Psychiatric side effects have included anxiety, depersonalization, depression, nervousness, sleep disorder, and abnormal thinking.
Ocular side effects have included conjunctivitis, eye abnormality, eye pain, and watery eyes.
Genitourinary side effects have included albuminuria, amenorrhea, breast pain, hematuria, and increased urinary frequency.
More Astepro resources
- Astepro Prescribing Information (FDA)
- Astepro Advanced Consumer (Micromedex) - Includes Dosage Information
- Astepro spray MedFacts Consumer Leaflet (Wolters Kluwer)
- Astepro Consumer Overview
- Astelin Prescribing Information (FDA)
- Astelin spray MedFacts Consumer Leaflet (Wolters Kluwer)
- Astelin Consumer Overview
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