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oxycodone

Pronunciation

Generic Name: oxycodone (ox i KOE done)
Brand Name: Oxecta, OxyCONTIN, Oxyfast, Roxicodone, ...show all 11 brand names

What is oxycodone?

Oxycodone is an opioid pain medication. An opioid is sometimes called a narcotic.

Oxycodone is used to treat moderate to severe pain.

The extended-release form of this medicine is for around-the-clock treatment of pain. This form of oxycodone is not for use on an as-needed basis for pain.

Oxycodone may also be used for purposes not listed in this medication guide.

What is the most important information I should know about oxycodone?

You should not use oxycodone if you have severe asthma or breathing problems, or a blockage in your stomach or intestines.

Oxycodone can slow or stop your breathing. Never use this medicine in larger amounts, or for longer than prescribed. Do not crush, break, or open an extended-release pill. Swallow it whole to avoid exposure to a potentially fatal dose. Oxycodone may also be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medicine in a place where others cannot get to it.

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MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Tell your doctor if you are pregnant. Oxycodone may cause life-threatening withdrawal symptoms in a newborn.

Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with oxycodone.

What should I discuss with my healthcare provider before using oxycodone?

You should not use oxycodone if you are allergic to it, or if you have:

  • severe asthma or breathing problems;

  • a blockage in your stomach or intestines; or

  • an allergy to any narcotic pain medicine (such as methadone, morphine, Oxycontin, Darvocet, Percocet, Vicodin, Lortab, and many others), or narcotic cough medicine that contains codeine, hydrocodone, or dihydrocodeine.

To make sure oxycodone is safe for you, tell your doctor if you have:

  • any type of breathing problem or lung disease;

  • a history of head injury, brain tumor, or seizures;

  • a history of drug abuse, alcohol addiction, or mental illness;

  • urination problems;

  • liver or kidney disease;

  • Addison's disease or other adrenal gland disorder; or

  • problems with your gallbladder, pancreas, or thyroid.

Oxycodone is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.

Tell your doctor if you are pregnant. If you use oxycodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

Oxycodone can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using oxycodone.

How should I use oxycodone?

Follow all directions on your prescription label. Oxycodone can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never take oxycodone in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Oxycodone may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away oxycodone is against the law.

Stop taking all other around-the-clock narcotic pain medicines when you start taking extended-release oxycodone (Oxycontin).

Do not crush, break, or open an extended-release pill. Swallow it whole to avoid exposure to a potentially fatal dose.

If your doctor has told you to take two or more oxycodone tablets per dose, take the tablets one at a time. Do not wet, presoak, or lick the tablet before placing it in your mouth. Drink plenty of water to make swallowing easier and to prevent choking.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not stop using oxycodone suddenly after long-term use. Ask your doctor how to avoid withdrawal symptoms when you stop using oxycodone.

Never crush or break an oxycodone pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death with the misuse of oxycodone and similar prescription drugs.

Store at room temperature, away from heat, moisture, and light.

Keep track of the amount of medicine used from each new bottle. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.

Do not keep leftover oxycodone pills or liquid. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush any unused pills or liquid medicine down the toilet.

What happens if I miss a dose?

Since oxycodone is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A oxycodone overdose can be fatal, especially in a child or other person using the medicine without a prescription.

What should I avoid while using oxycodone?

Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with oxycodone. Check your food and medicine labels to be sure these products do not contain alcohol.

This medicine may impair your thinking or reactions. Avoid driving or operating machinery until you know how oxycodone will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Grapefruit and grapefruit juice may interact with oxycodone and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

Oxycodone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using oxycodone and call your doctor at once if you have:

  • shallow breathing, slow heartbeat, cold, clammy skin;

  • seizure (convulsions);

  • confusion, severe drowsiness; or

  • a light-headed feeling, like you might pass out.

Common side effects may include:

  • mild drowsiness, headache, dizziness, tired feeling;

  • stomach pain, nausea, vomiting, constipation, loss of appetite;

  • dry mouth; or

  • mild itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Oxycodone dosing information

Usual Adult Dose for Pain:

The following dosing recommendations can only be considered suggested approaches to what is actually a series of clinical decisions over time in the management of the pain of each individual patient.
-Oxycodone oral solution is available in 2 concentrations (5 mg/mL and 20 mg/mL); to avoid dosing errors, include total dose in mg and mL when prescribing and dispensing.

Initial dose in opioid-naive patients:
-Immediate Release: 5 to 15 mg orally every 4 to 6 hours
-Oral solution 5 mg/mL: 5 to 15 mg orally every 4 to 6 hours
-Titrate according to patient's pain response and tolerability

-Oxycodone Oral Solution 100 mg per 5 mL (20 mg/mL) is for use in opioid-tolerant patients only; it may be used in patients who have been titrated to a stable analgesic regimen and who could benefit from the use of a smaller volume of oral solution.

Comments:
-When selecting the initial dose, take into account the patient's degree of opioid tolerance, patient's general condition and medical status, concurrent medications, type and severity of the pain, and risk factors for abuse, addiction, or diversion.
-When converting patients to oxycodone from other opioids or from other controlled-release oral oxycodone products, it is important to account for the inter-patient variability in the potency of opioid drugs and their formulations; it is best to underestimate a patients oral oxycodone requirement and provide rescue medication than to overestimate and manage an overdose; the manufacturer's product information and/or local protocol may be consulted for guidance.

Use: For the management of moderate to severe pain in patients who require treatment with an oral opioid analgesic.

Usual Adult Dose for Chronic Pain:

The following dosing recommendations can only be considered suggested approaches to what is actually a series of clinical decisions over time in the management of the pain of each individual patient.
-Oxycodone extended-release 60 and 80 mg tablets, a single dose greater than 40 mg, or a total daily dose greater than 80 mg are only for use in patients in whom tolerance to an opioid of comparable potency has been established.

Initial dose for opioid-naive and opioid non-tolerant patients:
-Extended-Release: 10 mg orally every 12 hours
-Titrate every 1 to 2 days according to patient's pain response and tolerability

Comments:
-Extended-release oxycodone products are reserved for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain; these products are not intended to be used as as-needed (prn) analgesics.
-When selecting the initial dose, take into account the patient's degree of opioid tolerance, patient's general condition and medical status, concurrent medications, type and severity of the pain, and risk factors for abuse, addiction, or diversion.

DOSE CONVERSIONS: Dose conversions should be done carefully and with close monitoring due to large patient variability in regards to opioid analgesic response; the manufacturer's product information and/or local protocol may be consulted for guidance.

Oxycodone Extended-Release (ER) TABLETS:
-The 60 and 80 mg tablets, a single dose greater than 40 mg, or a total daily dose greater than 80 mg are reserved for opioid tolerant individuals.
-Discontinue all other around the clock opioid drugs when initiating therapy with extended-release oxycodone.
CONVERSION FROM OTHER ORAL OXYCODONE FORMULATIONS:
-Administer one-half the patient's total daily oxycodone dose as extended-release oxycodone every 12 hours.
CONVERSION FROM OTHER ORAL OPIOIDS:
-Published potency tables can be used to estimate a patient's 24-hour oral oxycodone requirement; however, due to substantial inter-patient variability, it is best to underestimate a patient's 24-hour requirement and provide rescue medication as the dose is titrated.
CONVERSION FROM TRANSDERMAL FENTANYL: Remove the transdermal fentanyl patch and 18 hours later initiate oxycodone extended-release capsules at 10 mg every 12 hours for each 25 mcg/hr fentanyl transdermal patch; monitor closely as there is limited documented experience with this conversion.
CONVERSION FROM METHADONE:
-When converting from methadone, close monitoring is of particular importance due to methadone's long half-life.

Use: For the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.

What other drugs will affect oxycodone?

Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking oxycodone with a sleeping pill, muscle relaxer, other pain medicine, or medicine for anxiety, depression, or seizures.

Other drugs may interact with oxycodone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about oxycodone.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 10.07. Revision Date: 2015-06-08, 10:46:02 AM.

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