Generic Name: glyburide (GLYE bue ride)
Brand Names: DiaBeta, Glynase PresTab, Micronase
What is glyburide?
Glyburide is an oral diabetes medicine that helps control blood sugar levels.
Glyburide is used to treat type 2 diabetes.
This medication is not for treating type 1 diabetes.
Glyburide may also be used for other purposes not listed in this medication guide.
Important information about glyburide
You should not use this medication if you are allergic to glyburide, if you are being treated with bosentan (Tracleer), if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Before taking glyburide, tell your doctor if you are allergic to sulfa drugs, if you have been using insulin or chlorpropamide (Diabinese), or if you have hemolytic anemia (a lack of red blood cells), an enzyme deficiency (G6PD), a nerve disorder, liver disease, or kidney disease.
Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.
Before taking glyburide
You should not use this medication if you are allergic to glyburide, or:
if you are being treated with bosentan (Tracleer);
if you have type 1 diabetes; or
if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
To make sure you can safely take glyburide, tell your doctor if you have any of these other conditions:
hemolytic anemia (a lack of red blood cells);
an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
a nerve disorder affecting bodily functions;
- liver or kidney disease;
if you are allergic to sulfa drugs; or
if you have been using insulin or taking chlorpropamide (Diabinese).
Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glyburide.
FDA pregnancy category C. It is not known whether glyburide will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using glyburide. It is not known whether glyburide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have low blood sugar while taking glyburide.
See also: Glyburide pregnancy and breastfeeding warnings (in more detail)
How should I take glyburide?
Take glyburide exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
Take glyburide with your first meal of the day, unless your doctor tells you otherwise.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.
Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating.
Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.
Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.
Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.
Your doctor may want you to stop taking glyburide for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.
Ask your doctor how to adjust your glyburide dose if needed. Do not change your medication dose or schedule without your doctor's advice.
If there are any changes in the brand, strength, or type of glyburide you use, your dosage needs may change. Always check your refills to make sure you have received the correct brand and type of medicine prescribed by your doctor.
Store glyburide at room temperature, protected from moisture, heat, and light.
See also: Glyburide dosage (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glyburide overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
What should I avoid while taking glyburide?
Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment. Avoid exposure to sunlight or tanning beds. Glyburide can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Glyburide side effects
Stop using glyburide and get emergency medical help if you have any of these signs of an allergic reaction to glyburide: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking this medication and call your doctor at once if you have any of these serious side effects:
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
pale skin, confusion or weakness;
easy bruising or bleeding, purple or red pinpoint spots under your skin; or
headache, trouble concentrating, memory problems, feeling unsteady, hallucinations, fainting, seizure, shallow breathing or breathing that stops.
Less serious glyburide side effects may include:
mild nausea, heartburn, feeling full;
joint or muscle pain;
blurred vision; or
mild itching or skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Glyburide side effects (in more detail)
Glyburide Dosing Information
Usual Adult Dose of Glyburide for Diabetes Mellitus Type II:
Initial dose: 2.5 mg (standard) or 1.5 mg (micronized) orally once a day in the morning with breakfast.
Maintenance dose: 1.25 to 20 mg (standard) or 0.75 to 12 mg (micronized) orally in 1 or 2 divided doses.
Maximum dose: 20 mg/day (standard) or 12 mg/day (micronized).
Usual Geriatric Dose of Glyburide for Diabetes Mellitus Type II:
Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.
What other drugs will affect glyburide?
Tell your doctor about all other medications you use, especially:
a blood thinner such as warfarin (Coumadin, Jantoven);
cyclosporine (Gengraf, Neoral, Sandimmune);
fluconazole (Diflucan), ketoconazole (Nizoral);
rifampin (Rifadin, Rimactane, Rifater);
an ACE inhibitor such as enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others; or
an antibiotic such as ciprofloxacin (Cipro), levofloxacin (Levaquin), and others.
Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:
albuterol (Proventil, Ventolin);
beta-blockers such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others.
You may be more likely to have hyperglycemia (high blood sugar) if you take glyburide with:
diuretics (water pills);
steroids (prednisone and others);
phenothiazines (Compazine and others);
thyroid medicine (Synthroid and others);
birth control pills and other hormones;
heart or blood pressure medications (Cartia, Cardizem, Nifedical, Covera, Verelan, and others);
niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);
seizure medicines (Dilantin and others); and
diet pills or medicines to treat asthma, colds or allergies.
You may be more likely to have hypoglycemia (low blood sugar) if you take glyburide with:
heart or blood pressure medication (Accupril, Altace, Lotensin, Prinivil, Vasotec, Zestril, and others);
some nonsteroidal anti-inflammatory drugs (NSAIDs);
aspirin or other salicylates (including Pepto-Bismol);
sulfa drugs (Bactrim, Gantanol, Septra, and others);
a monoamine oxidase inhibitor (MAOI); and
other oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), or rosiglitazone (Avandia).
These lists are not complete and there are many other medicines that can increase or decrease the effects of glyburide on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More Glyburide resources
Compare Glyburide with other medications
Where can I get more information?
- Your pharmacist can provide more information about glyburide.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use glyburide only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
Copyright 1996-2012 Cerner Multum, Inc. Version: 9.03. Revision Date: 2012-06-16, 4:40:12 AM.