Glyburide Dosage

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Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Diabetes Type 2

Initial dose: 2.5 mg (standard) or 1.5 mg (micronized) orally once a day in the morning with breakfast.
Maintenance dose: 1.25 to 20 mg (standard) or 0.75 to 12 mg (micronized) orally in 1 or 2 divided doses.
Maximum dose: 20 mg/day (standard) or 12 mg/day (micronized).

Usual Geriatric Dose for Diabetes Type 2

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

Renal Dose Adjustments

Initial dose: 1.25 mg (standard) or 0.75 mg (micronized) orally once a day.

Liver Dose Adjustments

Initial dose: 1.25 mg (standard) or 0.75 mg (micronized) orally once a day.

Dose Adjustments

Dosage adjustments should be made in no more than 2.5 mg (standard) or 1.5 mg (micronized) increments every 7 days.

Management of noninsulin-dependent diabetes mellitus in patients previously maintained on insulin: Initial dosage dependent upon previous insulin:
Previous insulin dose: less than 20 units/day: Initial glyburide dose: 2.5 to 5 mg (conventional formulation) OR 1.5 to 3 mg (micronized formulation). Discontinue insulin after glyburide is started.
Previous insulin dose: 20 to 40 units/day: Initial glyburide dose: 5 mg (conventional formulation) OR 3 mg (micronized formulation).
Discontinue insulin after glyburide is started.
Previous insulin dose: greater than 40 units/day: Initial glyburide dose: 5 mg (conventional formulation) and increase in increments of 1.25 to 2.5 mg every 2 to 10 days OR 3 mg (micronized formulation) and increase in increments of 0.7 to 1.5 mg every 2 to 10 days.
Reduce insulin dosage by 50%, gradually taper off insulin as glyburide dosage is increased.

Precautions

Patients switched from longer acting agents, such as chlorpropamide, should be carefully monitored for hypoglycemia in the first 2 weeks of therapy.

Formulations of micronized glyburide (Glynase, Prestab) are not bioequivalent with conventional formulations (DiaBeta, Micronase) and dosage should be retitrated when transferring patients from one formulation to the other.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Glyburide is not hemodialyzed. Supplemental doses after dialysis are not necessary.

Other Comments

Administration Advice: Glyburide should be administered at least 4 hours prior to colesevelam to ensure that colesevelam does not reduce the absorption of glyburide.

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